A Comprehensive Review of Thyroid Eye Disease Pathogenesis: From Immune Dysregulations to Novel Diagnostic and Therapeutic Approaches DOI Open Access
Merve Kulbay, Stuti M. Tanya,

Nicolas Tuli

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11628 - 11628

Published: Oct. 29, 2024

Thyroid eye disease is a complex inflammatory disorder of the orbit that has gained tremendous interest over past years, and numerous scientific efforts have been deployed to elucidate its pathophysiology for novel drug development. Our manuscript will delve into molecular dysregulations involved in pathogenesis thyroid led clinical manifestations. Abnormalities within apoptotic pathway, cascade, autoimmune regulatory systems be covered. We further discuss challenges diagnosis management provide summary current diagnostic tools (i.e., biomarkers, scores) from perspective clinicians. Finally, our comprehensive literature review thorough most recent preclinical studies around topic disease, with an emphasis on manuscripts published last five years. believe bring novelty field by bridging fundamental sciences aspect this disease. This great tool clinicians better understanding while providing outlook future perspectives liquid biopsies, artificial intelligence).

Language: Английский

A Comprehensive Review of Thyroid Eye Disease Pathogenesis: From Immune Dysregulations to Novel Diagnostic and Therapeutic Approaches DOI Open Access
Merve Kulbay, Stuti M. Tanya,

Nicolas Tuli

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11628 - 11628

Published: Oct. 29, 2024

Thyroid eye disease is a complex inflammatory disorder of the orbit that has gained tremendous interest over past years, and numerous scientific efforts have been deployed to elucidate its pathophysiology for novel drug development. Our manuscript will delve into molecular dysregulations involved in pathogenesis thyroid led clinical manifestations. Abnormalities within apoptotic pathway, cascade, autoimmune regulatory systems be covered. We further discuss challenges diagnosis management provide summary current diagnostic tools (i.e., biomarkers, scores) from perspective clinicians. Finally, our comprehensive literature review thorough most recent preclinical studies around topic disease, with an emphasis on manuscripts published last five years. believe bring novelty field by bridging fundamental sciences aspect this disease. This great tool clinicians better understanding while providing outlook future perspectives liquid biopsies, artificial intelligence).

Language: Английский

Citations

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