Nuclear pseudoinclusion is associated with BRAFV600E mutation: Analysis of nuclear features in papillary thyroid carcinoma DOI Creative Commons
Agnes Stephanie Harahap, Dina Khoirunnisa,

Salinah

et al.

Annals of Diagnostic Pathology, Journal Year: 2025, Volume and Issue: 75, P. 152434 - 152434

Published: Jan. 6, 2025

Papillary thyroid carcinoma (PTC) is the most prevalent neoplasm, classified into BRAF-like and RAS-like subtypes. Nuclear alterations serve as a diagnostic criterion of PTC are fully manifested in BRAF-like. This single-center retrospective study aimed to assess different presentation nuclear features 40 samples BRAFV600E- RAS-mutated PTCs using both bivariate multivariate analytic approaches. evaluated histologically 3-point 8-point scoring systems established by World Health Organization Asian Thyroid Working Group, respectively. We found presence membrane irregularities, elongation, groove, sickle-shaped nuclei, pseudoinclusion, higher scores significantly associated with BRAFV600E. Multivariate analysis showed that pseudoinclusion predictive for BRAFV600E mutation (OR = 10.97, 95%CI 2.81-42.96, p 0.001) has sensitivity 55 %, specificity 92.5 positive value 88 negative 67.3 accuracy 73.8 %. There various pathways protooncogenes development neoplasm. significant differences between PTC. tend display florid features, whereas RAS- subtle features. These findings emphasize distinct cytological profiles BL RL PTC, reinforcing need precise subtyping guide tailored management.

Language: Английский

Nuclear pseudoinclusion is associated with BRAFV600E mutation: Analysis of nuclear features in papillary thyroid carcinoma DOI Creative Commons
Agnes Stephanie Harahap, Dina Khoirunnisa,

Salinah

et al.

Annals of Diagnostic Pathology, Journal Year: 2025, Volume and Issue: 75, P. 152434 - 152434

Published: Jan. 6, 2025

Papillary thyroid carcinoma (PTC) is the most prevalent neoplasm, classified into BRAF-like and RAS-like subtypes. Nuclear alterations serve as a diagnostic criterion of PTC are fully manifested in BRAF-like. This single-center retrospective study aimed to assess different presentation nuclear features 40 samples BRAFV600E- RAS-mutated PTCs using both bivariate multivariate analytic approaches. evaluated histologically 3-point 8-point scoring systems established by World Health Organization Asian Thyroid Working Group, respectively. We found presence membrane irregularities, elongation, groove, sickle-shaped nuclei, pseudoinclusion, higher scores significantly associated with BRAFV600E. Multivariate analysis showed that pseudoinclusion predictive for BRAFV600E mutation (OR = 10.97, 95%CI 2.81-42.96, p 0.001) has sensitivity 55 %, specificity 92.5 positive value 88 negative 67.3 accuracy 73.8 %. There various pathways protooncogenes development neoplasm. significant differences between PTC. tend display florid features, whereas RAS- subtle features. These findings emphasize distinct cytological profiles BL RL PTC, reinforcing need precise subtyping guide tailored management.

Language: Английский

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