Emerging mechanisms and targeted therapy of ferroptosis in cancer DOI Creative Commons
Haiyan Wang, Yan Cheng, Chao Mao

et al.

Molecular Therapy, Journal Year: 2021, Volume and Issue: 29(7), P. 2185 - 2208

Published: March 30, 2021

Ferroptosis is an iron- and lipid reactive oxygen species (ROS)-dependent form of programmed cell death that distinct from other forms regulatory at the morphological, biological, genetic levels. Emerging evidence suggests critical roles for ferroptosis in metabolism, redox status, various diseases, such as cancers, nervous system ischemia-reperfusion injury, with ferroptosis-related proteins. inhibited diverse cancer types functions a dynamic tumor suppressor development, indicating regulation can be utilized interventional target treatment. Small molecules nanomaterials reprogram cells to undergo are considered effective drugs therapy. Here, we systematically summarize molecular basis ferroptosis, suppressive effect on tumors, cellular metabolism microenvironment (TME), ferroptosis-inducing agents therapeutics. An understanding latest progress could provide references proposing new potential targets treatment cancers.

Language: Английский

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease DOI Creative Commons
Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayır

et al.

Cell, Journal Year: 2017, Volume and Issue: 171(2), P. 273 - 285

Published: Oct. 1, 2017

Language: Английский

Citations

5550
Ferroptosis: past, present and future DOI Creative Commons
Jie Li, Feng Cao,

He-liang Yin

et al.

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(2)

Published: Feb. 3, 2020

Abstract Ferroptosis is a new type of cell death that was discovered in recent years and usually accompanied by large amount iron accumulation lipid peroxidation during the process; occurrence ferroptosis iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting decrease antioxidant capacity reactive oxygen species (ROS) cells, ultimately leading to oxidative death. Recent studies have shown closely related pathophysiological processes many diseases, such as tumors, nervous system ischemia-reperfusion injury, kidney blood diseases. How intervene development diseases regulating has become hotspot focus etiological research treatment, but functional changes specific molecular mechanisms still need be further explored. This paper systematically summarizes latest progress research, with on providing references for understanding its pathogenesis proposing targets treatment

Language: Английский

Citations

2944
Broadening horizons: the role of ferroptosis in cancer DOI
Xin Chen, Rui Kang, Guido Kroemer

et al.

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(5), P. 280 - 296

Published: Jan. 29, 2021

Language: Английский

Citations

2034
Ferroptosis, a new form of cell death: opportunities and challenges in cancer DOI Creative Commons

Yanhua Mou,

Jun Wang, Jinchun Wu

et al.

Journal of Hematology & Oncology, Journal Year: 2019, Volume and Issue: 12(1)

Published: March 29, 2019

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies ferroptosis cancer have boosted perspective for its usage therapeutics. Here, we review the current findings regulation especially focus on function ncRNAs mediating process ferroptotic how was relation to other regulated deaths. Aberrant diverse types tissues were summarized, elaborated recent data about actors some "conventional" drugs natural compounds as inducers cancer. Finally, deliberate future orientation cells unsettled issues, which may forward speed clinical use induction treatment.

Language: Английский

Citations

1455
Targeting ferroptosis as a vulnerability in cancer DOI
Guang Lei, Li Zhuang, Boyi Gan

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(7), P. 381 - 396

Published: March 25, 2022

Language: Английский

Citations

1446
Recent Progress in Ferroptosis Inducers for Cancer Therapy DOI
Chen Liang, Xinglin Zhang, Mengsu Yang

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Oct. 8, 2019

Abstract Ferroptosis is a newly discovered form of regulated cell death that the nexus between metabolism, redox biology, and human health. Emerging evidence shows potential triggering ferroptosis for cancer therapy, particularly eradicating aggressive malignancies are resistant to traditional therapies. Recently, there has been great deal effort design develop anticancer drugs based on induction. Recent advances ferroptosis‐inducing agents at intersection chemistry, materials science, biology presented. The basis summarized first highlight feasibility characteristics therapy. A literature review inducers (including small molecules nanomaterials) then presented delineate their design, action mechanisms, applications. Finally, some considerations research spotlighted, followed by discussion challenges future development directions this burgeoning field.

Language: Английский

Citations

1274
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion DOI
José Pedro Friedmann Angeli, Dmitri V. Krysko, Marcus Conrad

et al.

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 19(7), P. 405 - 414

Published: May 17, 2019

Language: Английский

Citations

997
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity DOI Creative Commons
Rong Tang, Jin Xu, Bo Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2020, Volume and Issue: 13(1)

Published: Aug. 10, 2020

Abstract In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by fact that only one third of patients with most types respond to these agents. The induction cell death mechanisms other than apoptosis gradually emerged as a new treatment strategy because tumors harbor innate resistance apoptosis. date, possibility combining two modalities not been discussed systematically. Recently, few studies revealed crosstalk between distinct and antitumor immunity. pyroptosis, ferroptosis, necroptosis combined showed synergistically enhanced activity, even ICI-resistant tumors. Immunotherapy-activated CD8+ T cells traditionally believed induce tumor via following main pathways: (i) perforin-granzyme (ii) Fas-FasL. identified mechanism which suppress growth inducing ferroptosis provoked review relationship system activation. Hence, this review, we summarize knowledge reciprocal interaction immunity mechanisms, particularly necroptosis, three potentially novel immunogenic death. Because evidence is derived from using animal models, also reviewed related bioinformatics data available for human tissues public databases, partially confirmed presence interactions activation

Language: Английский

Citations

980
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer DOI Creative Commons
Haiyang Zhang, Ting Deng, Rui Liu

et al.

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Feb. 27, 2020

Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and drug resistance secreting various bioactive substances, including exosomes. Yet, the role CAFs regulating metabolism as well ferroptosis cancer cells still unexplored remains enigmatic.Ferroptosis-related genes gastric (GC) were screened using mass spectrum; exosomes isolated ultra-centrifugation CAF secreted miRNAs determined RT-qPCR. Erastin was used to induce ferroptosis, levels evaluated measuring lipid-ROS, viability mitochondrial membrane potential.Here, we provide clinical evidence show that arachidonate lipoxygenase 15 (ALOX15) closely related with lipid-ROS production cancer, exosome-miR-522 serves potential inhibitor ALOX15. By primary stromal cells, prove mainly derived from microenvironment. Moreover, heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) found mediate miR-522 packing into exosomes, ubiquitin-specific protease 7 (USP7) stabilizes hnRNPA1 through de-ubiquitination. Importantly, cisplatin paclitaxel promote secretion activating USP7/hnRNPA1 axis, leading ALOX15 suppression decreased accumulation ultimately result chemo-sensitivity.The present study demonstrates secrete exosomal inhibit targeting blocking accumulation. The intercellular pathway, comprising USP7, hnRNPA1, exo-miR-522 ALOX15, reveals new mechanism acquired chemo-resistance GC.

Language: Английский

Citations

782
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy DOI Creative Commons

Weitong Gao,

Yuqin Wang, Yang Zhou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: June 20, 2022

Abstract In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not ICIs, partly caused absence of tumor-infiltrating lymphocytes (TILs), significantly limits application ICIs. Converting these “cold” into “hot” may ICIs is an unsolved question immunotherapy. Since it a general characteristic cancers resist apoptosis, induction non-apoptotic regulated cell death (RCD) emerging as new treatment strategy. Recently, several studies have revealed interaction between RCD and antitumor immunity. Specifically, autophagy, ferroptosis, pyroptosis, necroptosis exhibit synergistic responses while possibly exerting inhibitory effects on responses. Thus, targeted therapies (inducers inhibitors) against combination with exert potent activity, resistant This review summarizes multilevel relationship immunity RCD, including necroptosis, potential targeting improve efficacy malignancy.

Language: Английский

Citations

612