Current Opinion in Structural Biology, Journal Year: 2025, Volume and Issue: 92, P. 103025 - 103025
Published: March 10, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 17, 2024
Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive remarkable transformation. Emerging fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, gene therapy. These cutting-edge not only afford personalized precise targeting, but also provide enhanced comfort potential to impede disease progression. Nonetheless, it is acknowledged that these strategies still harbour untapped for further advancement. Gaining understanding merits limitations holds promise offering novel perspectives clinical practice foundational research endeavours. In this review, we discussed different modalities, including drugs, peptide antibody cell therapy, It will detailed explanation each method, addressing their status development, challenges, solutions. The aim assist clinicians researchers in gaining deeper diverse options, enabling them carry out effective advance more efficiently.
Language: Английский
Citations
240
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 996 - 996
Published: July 12, 2023
Cyclic peptides are molecules that already used as drugs in therapies approved for various pharmacological activities, example, antibiotics, antifungals, anticancer, and immunosuppressants. Interest these has been growing due to the improved pharmacokinetic pharmacodynamic properties of cyclic structure over linear by evolution chemical synthesis, computational, vitro methods. To date, 53 have different regulatory authorities, many others clinical trials a wide diversity conditions. In this review, potential is presented, general aspects their synthesis development discussed. Furthermore, an overview also given, summarized.
Language: Английский
Citations
53
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114996 - 114996
Published: June 11, 2023
The escalating rate of cancer cases, together with treatment deficiencies and long-term side effects currently used drugs, has made this disease a global burden the 21st century. number breast lung patients sharply increased worldwide in last few years. Presently, surgical treatment, radiotherapy, chemotherapy, immunotherapy strategies are to cure cancer, which cause severe effects, toxicities, drug resistance. In recent years, anti-cancer peptides have become an eminent therapeutic strategy for due their high specificity fewer toxicity. This review presents updated overview different peptides, mechanisms action current production employed manufacture. addition, approved under clinical trials applications been discussed. provides information on that hold great promise near future.
Language: Английский
Citations
51
Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(7), P. 425 - 441
Published: May 27, 2023
Language: Английский
Citations
48
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Citations
3
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 166 - 166
Published: Feb. 7, 2025
Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA). Peptides present promising opportunity to address serious infections that may be challenging manage through other means. exhibit capability leverage various mechanisms, in some cases, multiple mechanisms are employed for this purpose. Despite initial dating back FDA recently approved an echinocandin peptide just last year. The ongoing approvals underscore significance peptides addressing medical challenges. Approximately 22 therapeutics antibacterial spectrum currently undergoing phases clinical trials, showing results. In review, analyzed terms their chemical structure, indication, mode action, development journey, concluding arrival pharmaceutical market.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1798 - 1798
Published: Feb. 1, 2024
Over the last few decades, we have witnessed growing interest from both academic and industrial laboratories in peptides as possible therapeutics. Bioactive a high potential to treat various diseases with specificity biological safety. Compared small molecules, represent better candidates inhibitors (or general modulators) of key protein–protein interactions. In fact, undruggable proteins containing large smooth surfaces can be more easily targeted conformational plasticity peptides. The discovery bioactive peptides, working against disease-relevant protein targets, generally requires high-throughput screening libraries, silico approaches are highly exploited for their low-cost incidence efficiency. present review reports on challenges linked employment therapeutics describes computational approaches, mainly structure-based virtual (SBVS), support identification novel therapeutic implementations. Cutting-edge SBVS strategies reviewed along examples applications focused diverse classes (i.e., anticancer, antimicrobial/antiviral blocking amyloid fiber formation).
Language: Английский
Citations
17
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 1032 - 1032
Published: March 2, 2024
The United States Food and Drug Administration (FDA) has approved a plethora of peptide-based drugs as effective in cancer therapy. Peptides possess high specificity, permeability, target engagement, tolerable safety profile. They exhibit selective binding with cell surface receptors proteins, functioning agonists or antagonists. also serve imaging agents for diagnostic applications can dual-purpose both therapeutic (theragnostic) agents. Therefore, they have been exploited various forms, including linkers, peptide conjugates, payloads. In this review, the FDA-approved prostate-specific membrane antigen (PSMA) antagonists, receptor radionuclide therapy (PRRT), somatostatin analogs, antibody–drug conjugates (ADCs), gonadotropin-releasing hormone (GnRH) other anticancer are analyzed terms their chemical structures properties, targets mechanisms action, development journey, administration routes, side effects.
Language: Английский
Citations
11
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(10), P. 510 - 510
Published: Sept. 26, 2023
Marine natural products are well-recognized as potential resources to fill the pipeline of drug leads enter pharmaceutical industry. In this circumstance, marine-derived fungi one unique sources bioactive secondary metabolites due their capacity produce diverse polyketides and peptides with structures biological activities. The present review covers from reported literature published January 1991 June 2023, various scientific databases, including Elsevier, ACS publications, Taylor Francis, Wiley Online Library, MDPI, Springer, Thieme, Bentham, ProQuest, Pharmacology website, used for a search. This focuses on chemical characteristics, sources, pharmacological activities 366 marine fungal belonging classes, such linear, cyclic, depsipeptides. Among 30 genera, isolated macro-organisms algae, sponges, coral, mangrove plants, well deep sea sediments, species Aspergillus were found highest number (174 peptides), followed by Penicillium (23 Acremonium (22 Eurotium (18 Trichoderma Simplicillium (17 Beauveria (12 peptides). cytotoxic activity against broad spectrum human cancer cell lines was predominant (32%), whereas antibacterial, antifungal, antiviral, anti-inflammatory, enzyme inhibition ranged 7% 20%. first part review, chemistry is discussed activity.
Language: Английский
Citations
20
Peptide Science, Journal Year: 2024, Volume and Issue: 116(4)
Published: Feb. 1, 2024
Abstract In the realm of therapeutic peptides, tremendous progress has been achieved in last two decades. The building block peptides that is, ‘Amino Acid’ modified by various chemical modifications such as side‐chain alteration linear cyclization, back‐bone modification, pro‐drug moiety, conjugation with heterocycles, and natural products to make a foremost candidate drug. Since advent insulin 1922, have immensely affected development pharmaceutical industry giving rise peptide‐based drug industry. recent years, having antimicrobial, antiviral, anti‐tumor, anti‐inflammatory, anti‐aging, antioxidant properties developed. Also, it now entered potent field oncology also become valuable tool radiolabeled peptide for detection diseases. Generally, were extracted from sources olden days, but presently work is directed towards finding alternate sustainable ways developing synthetic peptides. present review covers discussion about historic evaluation available effective processes, current advancements, use bioinformatic tools, computational strategies, methodology overcome barrier making future world.
Language: Английский
Citations
9