Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Journal of Orthopaedic Surgery and Research, Journal Year: 2023, Volume and Issue: 18(1)

Published: Aug. 9, 2023

Abstract Introduction In the aging process of body, in addition to changes fat and muscle content, there is also bone loss, implying possibility a strong muscle–bone–lipid link. this study, we initially investigated relationship between lumbar BMD low mass “muscle–bone–lipid.” Methods The datasets from National Health Nutrition Examination Survey (NHANES) 2011–2018 were used cross-sectional investigation. appendicular skeletal (ASM) measured by dual-energy X-ray absorptiometry (DXA), was adjusted body index (BMI) as marker sarcopenia. Weighted multivariate regression logistic analysis explore independent Fitted smoothing curves threshold effect describe nonlinear relationship. Result 8386 participants with ages 20–59 years, negative association fully model, risk developing sarcopenia decreased 93% for each 1-unit increase (OR = 0.07, 95%CI 0.03–0.20). 58% lower highest quartile than those lowest 0.42, 0.27–0.64). This more pronounced population women BMI ≥ 25. Conclusion Our findings suggest that negatively associated US adults. dynamic balance “muscle–bone–lipid” likely be related pathogenesis loss.

Language: Английский

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Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications

Journal of Bone Metabolism, Journal Year: 2024, Volume and Issue: 31(1), P. 1 - 12

Published: Feb. 29, 2024

Sarcopenia, which is characterized by an age-related decline in muscle mass and function, poses significant challenges to geriatric care. Its definition has evolved from muscle-specific criteria include mass, physical performance, recognizing sarcopenia as a frailty. Sarcopenia associated with adverse outcomes, including mortality, falls, fractures, cognitive decline, admission long-term care facilities. Neuromechanical factors, protein-energy balance, protein synthesis-breakdown mechanisms contribute its pathophysiology. The identification of involves screening tests comprehensive assessment strength, function. Clinical approaches aligned the principles prioritize patient-centered This aids identifying issues related activities daily living, cognition, mood, nutrition, social support, alongside other aspects. general approach factors underlying loss functional patients includes managing chronic diseases evaluating administered medications, interventions exercise well evolving pharmacological options. Ongoing research targeting pathways, such myostatin-activin mimetics, holds promise for interventions. In summary, requires multifaceted approach, acknowledging complex etiology tailoring individual patient needs.

Language: Английский

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Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1056 - 1056

Published: Oct. 7, 2023

Adiposity is central to aging and several chronic diseases. encompasses not just the excess adipose tissue but also body fat redistribution, infiltration, hypertrophy of adipocytes, shifting mesenchymal stem cell commitment adipogenesis. Bone marrow expansion, inflammatory adipokines, adipocyte-derived extracellular vesicles are development osteopenic adiposity. Adipose infiltration local adipogenesis within muscle critical in developing sarcopenic adiposity subsequent poorer functional outcomes. Ultimately, osteosarcopenic syndrome result all processes noted above: adipocyte expansion redistribution bone, muscle, tissues, resulting bone loss, mass/strength deteriorated tissue, decline. Increased typically referred as obesity expressed by mass index (the latter often used inadequately), now occurring younger age groups, suggesting people will live longer with negative effects This review discusses role deterioration well itself. It reveals how considering including definition diagnosis adiposity, help better understanding pathophysiology each accelerate possible therapies prevention approaches for both relatively healthy individuals or those disease.

Language: Английский

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Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4536 - 4536

Published: Oct. 26, 2023

The literature shows how sarcopenia often occurs along with different phenotypes based either on the concomitant presence of adipose tissue excess (i.e., sarcopenic obesity, SO), or osteopenia/osteoporosis (osteosarcopenia, OS), combination two conditions, so-called osteosarcopenic obesity (OSO). This research aimed to assess prevalence (SO, OS, OSO), their associated risk factors and health impact in a population out- inpatients living North Italy. Male female subjects aged ≥18 years were enrolled for study. A blood sample was collected measure targeted makers. comprehensive anthropometric clinical assessment (height, weight, Body Mass Index, BMI Dual Energy X-ray Absorptiometry, DXA) performed ponderal, bone, fat, muscle status. total 1510 individuals participated study (females, n = 1100; 72.85%). Sarcopenia most prevalent phenotype (17%), followed by osteosarcopenia (14.7%) obesity. Only 1.9% affected OSO. According logistic regression analysis, age, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) (positively) BMI, Iron (Fe), Total Cholesterol, albumin (%), (g), gamma proteins (negatively). Sarcopenic ferritin, ESR, CRP Fe, (%) Osteosarcopenia ESR Ca Osteosarcopenic glycemia gamma-glutamyl transferase (gGT) (positively). random forest higher important protective factor sarcopenia, (along Iron) albumin). Moreover, positively GgT glycaemia. possibility gaining such information, especially younger population, could help prevent onset diseases best fit patient's needs, according precision-medicine approach.

Language: Английский

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Assessing quality of life with SarQol is useful in screening for sarcopenia and sarcopenic obesity in older women

Aging Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 35(10), P. 2069 - 2079

Published: July 13, 2023

Health-related quality of life (HRQoL) may be impaired in the presence sarcopenia. Since a specific questionnaire became available for sarcopenia (SarQol), cutoffs to screen this condition have been proposed, prompting need assess them different populations. Due lack consensus on diagnostic criteria, tool has not yet analyzed screening sarcopenic obesity.Our aim is measure SarQoL's metric properties and establish cutoff QoL assessments that could used along pathway obesity community-dwelling older women.This cross-sectional study assessed women aged ≥ 70 years using SarQol, criteria (EWGSOP2) (ESPEN/EASO). Cutoffs SarQol were defined with receiver-operating characteristics (ROC) curve, sensitivity specificity analyzed.Of 95 included (mean age 76.0 years, standard deviation [SD] 5.7), 7.3% (n = 7) classified as having obesity, 22.1% 21) sarcopenia, 70.5% 67) The total score was higher without (66.5 SD 16.2) versus those (56.6 15.6) (45.1 7.9). A ≤ 60 points proposed (area under ROC curve [AUC] 0.67; 95% confidence interval [CI] 0.53-0.80; 61.9%; 62%), 50 (AUC 0.85; CI 0.74-0.95; 71.4%; 76.9%).Quality compromised especially obesity. useful these conditions, providing insight into health-related people

Language: Английский

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Sarcopenic obesity and osteoporosis: Research progress and hot spots

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 195, P. 112544 - 112544

Published: Aug. 22, 2024

Sarcopenic obesity (SO) and osteoporosis (OP) are associated with aging obesity. The pathogenesis of SO is complex, including glucolipid skeletal muscle metabolic disorders caused by inflammation, insulin resistance, other factors. Growing evidence links damage to bone loss. Muscle-lipid metabolism disrupt the balance between formation resorption, increasing risk OP. Conversely, bones also play a role in fat metabolism. In context obesity, comprehensive review focuses on effects mechanical stimulation, mesenchymal stem cells (MSCs), chronic myokines, adipokines musculoskeletal, at same time, impact osteokines muscle-lipid were analyzed. So far, exercise combined diet therapy most effective strategy for musculoskeletal mass. A holistic treatment diseases still preliminary exploration stage. Therefore, this article aims improve understanding -fat interactions OP, explores targets that can provide discusses current limitations challenges. We hope relevant ideas developing specific therapies improving disease prognosis future.

Language: Английский

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Lactose malabsorption and intolerance: What is the correct management in older adults?

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(12), P. 2540 - 2545

Published: Oct. 20, 2023

Language: Английский

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Association between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?

Life, Journal Year: 2023, Volume and Issue: 14(1), P. 21 - 21

Published: Dec. 21, 2023

Sarcopenic obesity (SO) is a frequent phenotype in people with obesity; however, it unclear whether this links an impaired bone status. In study, we aimed to investigate the association between SO and low mass, assess prevalence of new entity that combines excessive fat deposition, reduced muscle mass strength, defined as osteosarcopenic (OSO). Body composition was completed by DXA scan 2604 participants were categorized or without SO, normal mineral content (BMC). Participants both BMC OSO. Among entire sample, 901 (34.6%) met criteria for SO. This group showed mean (2.56 ± 0.46 vs. 2.85 0.57, p < 0.01) displayed higher individuals respect those (47.3% 25.9%, 0.01). Logistic regression analysis presence increases odds having 92% [OR = 1.92; 95% CI: (1.60–2.31), 0.05] after adjusting age, body weight, percentage. Finally, 426 (16.4%) out total sample affected Our findings revealed strong adults obesity, introduces fat, muscle, (i.e., OSO) appears affect 16% population.

Language: Английский

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Structural equation model analysis of the effect of visceral fat on osteoporosis

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: July 16, 2024

Abstract Background Osteoporosis is a considerable public health challenge in Moyu County, Xinjiang. Here, we evaluated the influencing factors of osteoporosis this region. Methods We recruited 7,761 participants and randomized them into normal osteoporotic populations based on T-score. The effects general conditions, body composition, calcium sources exercise, respiratory exposure, daily diet were analyzed. Furthermore, structural equation model was constructed to uncover direct indirect osteoporosis. Results Among participants, 1,803 (23.23%) had bone mass while 1,496 (19.28%) univariate analysis showed significant differences diet. Stratification age (45 years) index (BMI) (18.5 kg/m 2 ) variations composition between two groups; however, visceral fat differed significantly. Logistic regression affirmed association as it included all equations, except for female menopause. exhibited that and, sources, exercise osteoporosis, exposure factors. standardized path coefficient highest followed by lastly, exercise. Conclusion Obesity, besides menopause, also an factor plays vital role Our findings may provide experimental evidence early prevention treatment

Language: Английский

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