Tumor heterogeneity in retinoblastoma: a literature review DOI Creative Commons
Rani Pallavi,

Bihari Lal Soni,

Gaurab Kumar Jha

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(2)

Published: April 22, 2025

Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is key feature complex nature cancer. This diversity arises from emergence cells with varying genomic, epigenetic, transcriptomic, and phenotypic profiles over course disease. Host factors tumor microenvironment play crucial roles in driving both inter-patient intra-patient heterogeneity. These can exhibit different behaviors, such as rates proliferation, responses to treatment, potential for metastasis. Both heterogeneity pose significant challenges cancer therapeutics management. In retinoblastoma, while at clinical presentation level has been recognized some time, recent attention shifted towards understanding underlying cellular review primarily focuses on retinoblastoma its implications therapeutic strategies disease management, emphasizing need further research exploration this challenging area.

Language: Английский

Evaluation of milk thistle (Silybum marianum) phytochemicals as curative agents of retinoblastoma using in-silico approach DOI

Ayesha Yasmin,

Muhammad Naveed Shahid, Usman Arif

et al.

Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100992 - 100992

Published: Feb. 1, 2025

Language: Английский

Citations

0
Tumor heterogeneity in retinoblastoma: a literature review DOI Creative Commons
Rani Pallavi,

Bihari Lal Soni,

Gaurab Kumar Jha

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(2)

Published: April 22, 2025

Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is key feature complex nature cancer. This diversity arises from emergence cells with varying genomic, epigenetic, transcriptomic, and phenotypic profiles over course disease. Host factors tumor microenvironment play crucial roles in driving both inter-patient intra-patient heterogeneity. These can exhibit different behaviors, such as rates proliferation, responses to treatment, potential for metastasis. Both heterogeneity pose significant challenges cancer therapeutics management. In retinoblastoma, while at clinical presentation level has been recognized some time, recent attention shifted towards understanding underlying cellular review primarily focuses on retinoblastoma its implications therapeutic strategies disease management, emphasizing need further research exploration this challenging area.

Language: Английский

Citations

0