Comparative therapeutic and prophylactic efficacy of ethanol and water extracts of ginger in alleviating acetaminophen-induced hepatotoxicity and dyslipidemia DOI Creative Commons

Mohammed A Abdel-Rasol,

Nadia M. El‐Beih,

Wael M. El‐Sayed

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Background: Acetaminophen (APAP) overdose, common during pandemics like COVID-19, causes liver injury through oxidative stress. Ginger, known for its antioxidant properties, is suggested as a potential natural remedy. Objective: This study aimed to evaluate the therapeutic and prophylactic efficacy of ethanol ginger extract (GE) suspension (GS) on APAP-induced hepatotoxicity dyslipidemia in rats. Methods: Rats were assigned ten groups: control group, dimethyl sulfoxide groups receiving either GE or GS (150 mg/kg) two weeks. A group given single high dose APAP (2500 mg/kg), pre-treated with before APAP, three repeated doses (500 co-administrated along over Results: administration at regimens significantly impaired function, defenses, lipid metabolism. These disruptions included reduced levels markers such glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), S-transferase (GST), reductase (GR), peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH). Lipid metabolism alterations evident from increased triacylglycerols (TAGs), total cholesterol (T-chol), low-density lipoprotein (LDL-chol), alongside decreased high-density (HDL-chol). The resulted severe damage, indicated by elevated malondialdehyde (MDA), alanine aminotransferase (ALT), alkaline phosphatase (ALP), altered protein fractions. Both treatments alleviated these changes, particularly MDA, ALT, GPx, LDL-chol levels. demonstrated superior protective effects compared GS, restoring GSH, ALP, CAT, SOD, GST, GR, G6PDH, HDL-chol, albumin alpha-1 globulins. In contrast, showed slightly greater reducing TAGs T-chol Conclusions: Ginger extracts offer significant protection against damage dyslipidemia, providing more pronounced effects.

Language: Английский

Unveiling the Miracle Tree: Therapeutic Potential of Moringa oleifera in Chronic Disease Management and Beyond DOI Creative Commons
Edgar Yebrán Villegas-Vázquez, Rocío Gómez-Cansino, Gabriel Marcelino-Pérez

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 634 - 634

Published: March 5, 2025

Moringa oleifera (MO) has gained recognition as a potent natural intervention for preventing and managing chronic diseases (CDs) due to its diverse phytochemical composition pharmacological properties. Rich in antioxidants, polyphenols, flavonoids, glucosinolates, MO exerts anti-inflammatory, anti-hyperglycemic, cardioprotective, anti-obesity effects. These properties make it valuable therapeutic agent CDs, including diabetes, cardiovascular diseases, obesity, neurodegenerative disorders, cancer. MO’s ability modulate oxidative stress inflammation—key drivers of CDs—highlights significant role disease prevention treatment. enhances insulin sensitivity, regulates lipid profiles blood pressure, reduces inflammation, protects against damage. also modulates key signaling pathways involved cancer liver prevention. Studies suggest that extracts possess anticancer activity by modulating apoptosis, inhibiting tumor cell proliferation, interacting with pathways, YAP/TAZ, Nrf2-Keap1, TLR4/NF-κB, Wnt/β-catenin. However, challenges such variability bioactive compounds, taste acceptability, inconsistent clinical outcomes limit their widespread application. While preclinical studies support efficacy, large-scale trials, standardized formulations, advanced delivery methods are needed optimize potential. multifunctional applications promising sustainable solution combating especially resource-limited settings.

Language: Английский

Citations

1
Comparative therapeutic and prophylactic efficacy of ethanol and water extracts of ginger in alleviating acetaminophen-induced hepatotoxicity and dyslipidemia DOI Creative Commons

Mohammed A Abdel-Rasol,

Nadia M. El‐Beih,

Wael M. El‐Sayed

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Background: Acetaminophen (APAP) overdose, common during pandemics like COVID-19, causes liver injury through oxidative stress. Ginger, known for its antioxidant properties, is suggested as a potential natural remedy. Objective: This study aimed to evaluate the therapeutic and prophylactic efficacy of ethanol ginger extract (GE) suspension (GS) on APAP-induced hepatotoxicity dyslipidemia in rats. Methods: Rats were assigned ten groups: control group, dimethyl sulfoxide groups receiving either GE or GS (150 mg/kg) two weeks. A group given single high dose APAP (2500 mg/kg), pre-treated with before APAP, three repeated doses (500 co-administrated along over Results: administration at regimens significantly impaired function, defenses, lipid metabolism. These disruptions included reduced levels markers such glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), S-transferase (GST), reductase (GR), peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH). Lipid metabolism alterations evident from increased triacylglycerols (TAGs), total cholesterol (T-chol), low-density lipoprotein (LDL-chol), alongside decreased high-density (HDL-chol). The resulted severe damage, indicated by elevated malondialdehyde (MDA), alanine aminotransferase (ALT), alkaline phosphatase (ALP), altered protein fractions. Both treatments alleviated these changes, particularly MDA, ALT, GPx, LDL-chol levels. demonstrated superior protective effects compared GS, restoring GSH, ALP, CAT, SOD, GST, GR, G6PDH, HDL-chol, albumin alpha-1 globulins. In contrast, showed slightly greater reducing TAGs T-chol Conclusions: Ginger extracts offer significant protection against damage dyslipidemia, providing more pronounced effects.

Language: Английский

Citations

0