Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114607 - 114607
Published: March 6, 2025
Language: Английский
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Patients and healthcare systems face significant social financial challenges due to the increasing number of individuals with chronic external internal wounds that fail heal. The complexity healing process remains a serious health concern, despite effectiveness conventional wound dressings in promoting healing. Recent advancements materials science fabrication techniques have led development innovative enhance To further expedite process, novel approaches such as nanoparticles, 3D-printed dressings, biomolecule-infused emerged, along cell-based methods. Additionally, gene therapy technologies are being harnessed generate stem cell derivatives more functional, selective, responsive than their natural counterparts. This review highlights potential biomaterials, 3D bioprinting, gene- therapies However, it also underscores necessity for research address existing integrate these strategies into standard clinical practice.
Language: Английский
Citations
3
Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 93 - 93
Published: Feb. 7, 2025
Effective bladder reconstruction remains a significant challenge in urology, particularly for conditions requiring partial or complete replacement. In this study, the efficacy is evaluated of two types scaffolds, silk fibroin (SF) and adipose-derived stem cells (ADSCs-SF), promoting regeneration their associated outcomes. A rat model was used to compare surgical outcomes morphological recovery tissues implanted with SF ADSCs-SF scaffolds. Post-operative recovery, including voiding ability complication rates, assessed. The histological changes regenerated tissue were at multiple time points (2, 4, 8, 12 weeks) using gross analysis, histometric assessments, immunohistochemical staining. Both scaffold demonstrated successful integration into wall no differences body weight issues. group exhibited graft shrinkage 41.6% incidence calculus formation. contrast, facilitated superior restoration, progressively adopting more normal shape calculus. Histological analysis revealed that significantly promoted organized urothelium layer smooth muscle tissue. It also resulted higher vessel density reduced infiltration inflammatory when compared alone. Additionally, enhanced expression key markers, uroplakin III, urothelial marker, α-SMA, cell marker. These findings suggest not only supports structural integrity but improves reduces adverse responses, offering promising approach repair reconstruction.
Language: Английский
Citations
1
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24
Published: Feb. 28, 2025
This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess morphology, cell proliferation, viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, observer with lacking nanoparticles, treatment nanoparticle-enhanced post-injury repair. At 15, 30, 60 days post-surgery, the rabbits were humanely euthanized, excised tissue samples fixed 10% formalin histopathological analysis, then processed embedded paraffin microscopic evaluation. Statistical analysis performed SPSS software ANOVA Tukey's post hoc test. Results indicated that supported viability encouraged differentiation chondrocyte-like phenotypes. Scanning Electron Microscopy (SEM) confirmed hydrogels' porosity showed significant differences survival rates compared group, underscoring potential engineering regenerative strategies.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114607 - 114607
Published: March 6, 2025
Language: Английский
Citations
0