Podocyte-related biomarkers' role in evaluating renal toxic effects of silver nanoparticles with the possible ameliorative role of resveratrol in adult male albino rats DOI Creative Commons
Eman El‐Sayed Khayal,

Mona G. Elhadidy,

Sulaiman Mohammed Alnasser

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101882 - 101882

Published: Dec. 27, 2024

Extensive uses of silver nanoparticles (Ag NPs) in different industries result exposure to these nanoparticle imperatives our daily lives. Resveratrol is found many plants as a natural compound. The present study aimed estimate the renal toxic effects Ag NPs adult male albino rats and underlying relevant mechanisms while studying possible role resveratrol ameliorating effects. Thirty were split into 5 groups; control, vehicle, (30 mg/kg), (300 + groups. treatments given orally for 4 weeks. group displayed reduction kidney weight ( absolute relative), excess urinary levels injury molecule, neutrophil gelatinase-associated lipocalin, cystatin, blood biomarkers (creatinine, urea, potassium), increases oxidative stress markers with antioxidant markers, decreases serum sirtuin 1(SIRT1) level. Upregulation interleukin 1 beta, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 gene expressions downregulation nephrin podocin tissues also observed. These changes associated histological alterations glomeruli tubules, increased area percentage collagen fiber. A significant increase optical density transforming growth factor-beta claudin-1 immunostaining was detected when compared other All alleviated by usage through its anti-oxidant, anti-inflammatory, activation SIRT1 recommending use renoprotective agent.

Language: Английский

Eco-friendly green synthesis of AgNPs from Elaeocarpus serratus fruit extract: potential to antibacterial, antioxidant, cytotoxic effects of colon cancerous cells (HT-29) and its toxicity assessments of marine microcrustacean Artemia nauplii DOI

Venkatachalam Balamurugan,

Chinnasamy Ragavendran,

Dhanarajan Arulbalachandran

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: March 14, 2024

Language: Английский

Citations

13
Nanotechnology in textiles: Environmental safety and sustainable practices DOI

Sunita Boruah,

Seiko Jose

Environmental Nanotechnology Monitoring & Management, Journal Year: 2025, Volume and Issue: unknown, P. 101062 - 101062

Published: March 1, 2025

Language: Английский

Citations

0
Green synthesis of silver nanoparticles using cocoon extract of Bombyx mori L.: therapeutic potential in antibacterial, antioxidant, anti-inflammatory, and anti-tumor applications DOI Creative Commons
Ahmed H. Elsaffany, Ahmed E. M. Abdelaziz,

Abdullah A. Zahra

et al.

BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 14, 2025

Language: Английский

Citations

0
Royal Jelly–Mediated Silver Nanoparticles Show Promising Anticancer Effect on HeLa and A549 Cells Through Modulation of the VEGFa/PI3K/Akt/MMP‐2 Pathway DOI

Meri Kocharyan,

Syuzan Marutyan, Edita Nadiryan

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(12)

Published: Aug. 27, 2024

ABSTRACT In recent years, nanotechnology has revolutionized various sectors, particularly in nanomedicine, where nanomaterials are used for diagnosis, monitoring, control, prevention, and treatment. Among these, silver nanoparticles (AgNPs) stand out due to their remarkable antimicrobial cytotoxic properties. Traditional chemical synthesis of AgNPs poses significant environmental health risks. This study introduces a novel, eco‐friendly method using royal jelly (RJ), nutrient‐rich secretion from honeybees, produce with potent anticancer effects. Our research provides detailed investigation into RJ‐mediated AgNPs’ modulation the VEGFa/PI3K/Akt/MMP‐2 pathway HeLa A549 cancer cell lines. AgNP characterization was performed by applying UV–Vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) combination selected area diffraction (SAED). Cell signaling system components were determined ELISA analysis. The cells subjected staining hematoxylin eosin visualize treatment’s focuses on green RJ its bioactivity against cells. It examines effects cells, specifically cervical lung Green synthesized demonstrate underlying molecular mechanisms contributing activity elucidated. findings revealed decrease arginase upon exposure AgNPs, accompanied reductions PI3K phosphorylated total Akt levels, indicative inhibition. Additionally, RJAgNP demonstrated capacity reduce nitric oxide levels suppress angiogenesis‐related factors like VEGF MMP‐2 inflammation‐related TNF‐α COX‐2, thus impeding angiogenesis metastasis. Moreover, our results shed involvement reactive oxygen intermediates (ROIs) mediating apoptotic pathways, as evidenced increase malondialdehyde (MDA) concentration corresponding ultimately promoting death contributes significantly field nanomedicine therapy introducing use providing in‐depth insights action. potential RJ‐AgNPs targeting ROS/RNS

Language: Английский

Citations

3
Advanced Nanomaterials for Water Treatment: Synthesis Methods and Application DOI

Nadeeka Lakshani,

Rajitha Rathnayaka,

Chanaka Sandaruwan

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The SABYDOMA safety by process control framework for the production of functional, safe and sustainable nanomaterials DOI

Argyri Kardamaki,

Athanassios Nikolakopoulos,

Michail E. Kavousanakis

et al.

Computers & Chemical Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 109113 - 109113

Published: April 1, 2025

Language: Английский

Citations

0
The Toxicological Profile of Active Pharmaceutical Ingredients–Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications DOI Creative Commons
Muhaimin Muhaimin, Anis Yohana Chaerunisaa, Mayang Kusuma Dewi

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 703 - 703

Published: May 9, 2025

Nanotechnology is the manipulation of matter on an atomic and molecular scale, producing a lot new substances with properties that are not necessarily easily expected based present knowledge. produces unique can be beneficial or harmful depending their biocompatibility distribution. Understanding nanomaterial toxicity essential to ensure safe application in biological environmental applications. This review aims provide comprehensive overview nanoparticle toxicity, focusing physicochemical properties, mechanisms cellular uptake, potential health risks. Key factors influencing include particle size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, agglomeration. Nanoparticles induce oxidative stress inflammation, contributing adverse effects when inhaled, ingested, applied skin. However, may limited just these pathways, as they also exhibit other toxic such activation apoptotic pathway mitochondrial damage. By summarizing current knowledge aspects, this article intends support development nanoparticles safer way for future

Language: Английский

Citations

0
Geothermal Flora and AgNPs Synergy: A Study on the Efficacy of Lantana camara and Acrostichum aureum-Infused Hand Sanitizers DOI

Cheariva Firsa Harera,

Hilda Maysarah,

Pati Kemala

et al.

Grimsa Journal of Science Engineering and Technology, Journal Year: 2024, Volume and Issue: 2(2), P. 52 - 59

Published: Sept. 11, 2024

Hand hygiene is an important factor that needs to be observed in controlling the spread of diseases transmitted through hand-to-hand contact. Synthesis silver nanoparticles from tembelekan (Lantana camara) and paku laut (Acrostichum aureum) using green synthesis method has good antibacterial activity against Staphylococcus aureus Escherichia coli bacteria. Therefore, a preparation formulation was made, namely hand sanitizer, which still rarely used. Formulations have successfully entered evaluation stage include organoleptic tests, homogeneity spreadability adhesion viscosity pH accelerated stability irritation tests. Antibacterial evaluated bacteria coli. The sanitizer formulated contain 5% AgNPs (F1); (F2); combination 2.5% AgNPs. resulting characteristics, except for color preparation, changed during test. Test results pH, adhesion, spreadability, viscosity, meet requirements Irritation tests on ten volunteers showed no reaction. show bacterial with average ± standard deviation inhibition zone 6.605±0.459(F1); 6.665±0.615(F2); 6.380±0.282(F3) dan 6.575 0.219 6.860 0.155 6.810 0.056 (F3). Making AgNPs-based ingredients plants can used as but stabilizers are required prevent changes storage.

Language: Английский

Citations

2
Impact of Two Lavender Extracts on Silver Nanoparticle Synthesis, and the Study of Nanoparticles’ Antibiofilm Properties and Their Ability to Transfer them into a Nontoxic Polymer DOI Creative Commons
Lívia Mačák, Oksana Velgosová, Silvia Dolinská

et al.

Micro, Journal Year: 2023, Volume and Issue: 3(4), P. 879 - 891

Published: Nov. 17, 2023

In this work, we aimed to analyze the impact of extracts prepared from dried Lavandula angustifolia (lavender) flowers and leaves on synthesis silver nanoparticles (AgNPs) (wherein shape size AgNPs efficiency process were analyzed) prove possibility transferring AgNPs’ properties into a polymer matrix. An ex situ method was used incorporate prepare matrix composite (PVP-AgNPs) films (via casting) fibers electrospinning). We UV-vis absorption spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Scanning (SEM) characterize composites. The results FTIR analysis confirmed presence phytochemicals that can reduce ions Ag+ Ag0 in both extracts. spherical via TEM regardless type extract used. However, leaf caused formation with narrower interval (an average 20 nm), higher efficiency, compared using flower extract. then incorporated matrix, thin successfully prepared. anti-biofilm activity colloids nanocomposites against green algae Chlorella kessleri studied. proved, along efficient transfer their toxic nontoxic polymer.

Language: Английский

Citations

2
Royal Jelly-Mediated Silver Nanoparticles Show Promising Anti-Cancer Effect on HeLa and A549 Cells Through Modulation of the VEGFa/PI3K/Akt/MMP-2 Pathway DOI Creative Commons

Meri Kocharyan,

Syuzan Marutyan, Edita Nadiryan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 11, 2024

Abstract Cancer poses a significant challenge in the medical field, requiring thorough investigation into its mechanisms and development of effective treatments. Recently, there has been increasing interest integrating drugs with metal nanoparticles, which are notable for their unique size physicochemical properties, aiming to enhance anticancer efficacy. Silver nanoparticles (AgNPs), especially those obtained through environmentally friendly methods known as green synthesis, have garnered attention. Royal jelly (RJ), substance produced by bees recognized antioxidant, anti-inflammatory, antibacterial is particularly interesting. This study focuses on synthesis AgNPs using royal bioactivity against cancer cells. It provides detailed characterization examines effects cells, specifically Hela cervical A549 lung cell lines. The results highlight cytotoxicity induced HeLa mediated apoptosis via PI3K/AKT signaling pathway. Our research findings demonstrate that one underlying death involves increased concentration ROS/RNS downregulation VEGFa/MMP-2/COX-2 among few elucidate mechanism synthesized this method. Overall, our contributes ongoing exploration biology offers insights potential therapeutic approaches harnessing capabilities green-synthesized nanoparticles.

Language: Английский

Citations

0