The effect of cardiovascular–kidney–metabolic disease on pulse pressure in patients with type II diabetes

Journal of current cardiology., Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Abstract CONTEXT: Cardiovascular–kidney–metabolic (CKM) syndrome is a complex condition arising from interrelated factors such as heart disease, diabetes mellitus (DM), kidney dysfunction, and obesity. These may cause multiple organ failure, thus impacting patient’s health. AIMS: The aim of this study was to explore the association between CKM risk factors, estimated glomerular filtration rate, blood pressure, albumin-creatinine ratio, age, body mass index (BMI), low-density lipoprotein cholesterol, glycated hemoglobin (HbA1c), pulse pressure (PP) in patients with type 2 DM (T2DM). METHODOLOGY: Retrospective, cross-sectional conducted using 32,333 T2DM patients’ data Diamond database at single center. Multivariate regression analysis assessed relationship PP associated factors. RESULTS: revealed significant positive correlations age ( r = 0.412), BMI 0.019), albuminuria 0.092), HbA1c levels 0.115). correlation found be significant; 1-year increase corresponded 0.474 mmHg rise R 0.171; P < 0.001). CONCLUSIONS: PP, crucial marker for cardiorenal disease patients, can aid determining developing syndrome. Currently, strategies identifying managing are not well defined, resulting gaps appropriate screening metabolic subclinical cardiovascular chronic disease. However, assessment these individual parameters monitoring offer substantial benefits early detection management syndrome, thereby improving patient outcomes.

Language: Английский

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The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11453 - 11453

Published: Oct. 23, 2021

Chronic kidney disease can progress to end-stage chronic renal (ESRD), which requires the use of replacement therapy (dialysis or transplant) in life-threatening conditions. In ESRD, irreversible changes kidneys are associated with systemic proinflammatory nature and dysfunctions internal organs, skeletal muscles, integumentary tissues. The common components ESRD pathogenesis, regardless initial nosology, (1) local (in kidneys) low-grade inflammation (ChLGI) as a risk factor for diabetic its progression (2) classical type characteristic primary secondary autoimmune glomerulonephritis infectious recurrent pyelonephritis, well immune reactions allograft rejection, (3) (ChSI), pathogenetically characterized by latent microcirculatory disorders manifestations paracoagulation. development ChSI is closely programmed hemodialysis process. Consideration pathogenesis from standpoint theory general pathological processes opens up scope not only particular but also universal approaches conducting pathogenetic therapies diagnosing predicting complications severe nephropathies.

Language: Английский

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Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway

BMC Nephrology, Journal Year: 2021, Volume and Issue: 22(1)

Published: June 10, 2021

Abstract Background Adiponectin is an adipocytokine that plays a key regulatory role in glucose and lipid metabolism obesity. The prevalence of obesity has led to increase the incidence obesity-related glomerulopathy (ORG). This study aimed identify protective adiponectin ORG. Methods Small-interfering RNA (siRNA) against gene encoding was transfected into podocytes. oxidative stress level determined using fluorometric assay. Apoptosis analyzed by flow cytometry. expressions podocyte markers pyrin domain containing protein 3 (NLRP3) inflammasome-related proteins were measured qRT-PCR, immunohistochemistry, Western blot. Results Podocytes treated with palmitic acid (PA) showed downregulated markers, increased apoptosis, upregulated levels NLRP3 proteins, production inflammatory cytokines (IL-18 IL-1β), induced activation NF-κB as compared vehicle-treated controls. Decreased expression observed serum samples from high fat diet (HFD)-fed mice. podocin kidney Treatment or inflammasome inhibitor, MCC950, protected cultured podocytes apoptosis inflammation. mouse tissues decreased expression. knockout siRNA ROS production, resulting phosphorylation Pyrrolidine dithiocarbamate, prevented ameliorating FFA-induced injury activation. Conclusions Our ameliorated PA-induced vitro HFD-induced vivo via inhibiting ROS/NF-κB/NLRP3 pathway. These data suggest potential use for prevention treatment

Language: Английский

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Beyond the Cardiorenal Syndrome: Pathophysiological Approaches and Biomarkers for Renal and Cardiac Crosstalk

Diagnostics, Journal Year: 2022, Volume and Issue: 12(4), P. 773 - 773

Published: March 22, 2022

Cardiorenal syndrome encompasses complex multifactorial facets and carries significant morbidity mortality worldwide. The bi-directional relationship between the heart kidneys, where dysfunction in one organ worsens function of other, has been leading motor for research last few years. In pathophysiological process, small noncoding RNAs, epigenetics, vascular growth factors, oxidative stress, hemodynamic biomarkers play a pivotal role development cardiorenal syndrome. It is therefore important to elucidate all mechanisms order provide diagnostic treatments tools. This review summarizes non-hemodynamic pathways along with that could be next target diagnosis, treatment, prognosis

Language: Английский

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Association between triglyceride-glucose index and its composite obesity indexes and cardio-renal disease: analysis of the NHANES 2013-2018 cycle

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

The association between triglyceride-glucose (TYG) and its composite obesity indexes cardio-renal disease in the American population remains insufficiently researched. This study examined a cohort of 11,491 adults aged 20 years older from 2003-2018 National Health Nutrition Examination Survey (NHANES). To explore associations TYG, TyG-Waist-to-Height Ratio (TyG-WHtR), TyG-Body Mass Index (TyG-BMI), TyG-Waist Circumference (TyG-WC), chronic kidney (CKD), cardiovascular (CVD), cardiorenal syndrome (CRS), we utilized weighted multivariate logistic regression, restricted cubic spline (RCS), Receiver operating characteristic (ROC), subgroup analyses. Adjusted for confounding factors, there are positive likelihood CKD, CVD, CRS, as well TYG indexes. index was correlated most strongly with CKD (OR 1.42, 95% CI 1.11, 1.82; P = 0.007), while TyG-WHtR had strongest correlations CVD 1.63, 1.19, 2.22; 0.003) CRS 1.44, 1.00, 2.08; 0.055). A nonlinear connection found by RCS analysis (P overall < 0.001, 0.05), predominantly linear > 0.05). Based on ROC curves, TyG-WC emerged more reliable diagnostic tools than cardiac renal diseases. According to analyses, TyG measurements were associated younger individuals (≤ 50), males, those diabetes mellitus interaction an increased risk disease, indicating enhanced accuracy. These metrics provide effective tool identifying early improving stratification.

Language: Английский

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Remnant cholesterol in obesity phenotypes: results from NHANES

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 9, 2025

The association between remnant cholesterol (RC) with obesity phenotypes remains unclear. This study designed to evaluate the RC and using data from National Health Nutrition Examination Survey (NHANES). classification systems for encompassed both preclinical/clinical stages, which were assessed based on two authoritative guidelines: 2025 clinical guideline, 2016 guideline established by American Association of Clinical Endocrinologists College Endocrinology (AACE/ACE). Participants selected according diagnostic criteria proposed in categorized into tertiles their levels. Their phenotypes, obesity-related manifestations, comorbidities, characteristics then described. Logistic regression analyses restricted cubic spline (RCS) models used analyze relationship adverse phenotypes. Sensitivity conducted patients not receiving lipid-lowering drugs. comprised 3,207 adult participants, revealing distinct prevalence patterns: 47.80% exhibited preclinical 17.81% showed obesity, while stage stratification demonstrated 0%, 12.76%, 21.63% 0, 1, 2, respectively. Multivariable dose-response levels individuals highest tertile showing significantly elevated risks (OR 1.95, 95% CI 1.19-3.19) progression 1.96, 1.06-3.62) compared lowest reference group. RCS further revealed similar "J"-shaped (P nonlinearity < 0.001), sharing a common inflection point at 0.51 mmol/L. sensitivity confirmed consistency results among who therapy. was found be positively independently associated particularly when exceeded mmol/L, demonstrating association. It is recommended that clinicians monitor obese as primary screening indicator obesity.

Language: Английский

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Editorial comment on “The effect of cardiovascular–kidney–metabolic disease on pulse pressure in patients with type II diabetes”

Journal of current cardiology., Journal Year: 2025, Volume and Issue: 3(1), P. 18 - 20

Published: Jan. 1, 2025

Language: Английский

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Dietary Patterns Associated with Diabetes in an Older Population from Southern Italy Using an Unsupervised Learning Approach

Sensors, Journal Year: 2022, Volume and Issue: 22(6), P. 2193 - 2193

Published: March 11, 2022

Dietary behaviour is a core element in diabetes self-management. There are no remarkable differences between nutritional guidelines for people with type 2 and healthy eating recommendations the general public. This study aimed to evaluate dietary subjects without describe any emerging patterns characterizing diabetic subjects. In this cross-sectional conducted on older adults from Southern Italy, habits “Diabetic” “Not Diabetic” groups were assessed FFQ, derived using an unsupervised learning algorithm: principal component analysis. Diabetic (n = 187) more likely be male, slightly older, lower level of education than diabetes. The diet reflected high-frequency intake dairy products, eggs, vegetables greens, fresh fruit nuts, olive oil. On other hand, consumption sweets sugary foods was reduced compared non-diabetics (23.74 ± 35.81 vs. 16.52 22.87; 11.08 21.85 7.22 15.96). had higher red meat, processed ready-to-eat dishes, alcoholic drinks, vegetable consumption. present demonstrated that, areas around Mediterranean Sea, healthier their non-diabetic counterparts.

Language: Английский

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Unlocking the Nutritional Power of Vegetables: A Guide to Vibrant Health

European Journal of Nutrition & Food Safety, Journal Year: 2024, Volume and Issue: 16(8), P. 247 - 261

Published: Aug. 10, 2024

Vegetable consumption is essential for preserving optimum health and wellbeing. This review explores the nutritional value of vegetables, emphasising their abundance vitamins, minerals, bioactive substances in addition to other important nutrients. Vegetables are boosting mental health, lowering risk chronic diseases, raising standard living. They provide advantages like nutrient density, digestive support, antioxidant defence while fostering vitality energising health. Also highlights significance eating a varied, well-balanced diet full vibrant, colourful vegetables order guarantee varied intake phytochemicals that have particular benefits. Furthermore, function controlling blood sugar examined, highlighting high fibre content, low glycemic index, polyphenol which improves insulin sensitivity. People can attain sustain best possible vitality, well-being by including variety regular diets. There doable methods adding more veggies diets, these plant-based nutrients healthy way

Language: Английский

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Modulation of insulin resistance by renin angiotensin system inhibitors: implications for cardiovascular prevention

Monaldi Archives for Chest Disease, Journal Year: 2021, Volume and Issue: 91(2)

Published: March 11, 2021

Insulin resistance (IR) and the related hyperinsulinamia play a key role in genesis progression of continuum cardiovascular (CV) disease. Thus, it is reasonable to pursue primary secondary CV prevention, pharmacological strategies that are capable interfere with development IR. The renin-angiotensin-aldosterone system (RAAS) plays an important pathogenesis In particular, angiotensin II (Ang II) through generation reactive oxygen species, induces low grade inflammation, which impairs insulin signal transduction. converting enzyme (ACE) inhibitors effective not only as blood pressure-lowering agents, but also modulators metabolic abnormalities. Indeed, experimental evidence indicates animal models IR, ACE ameliorate sensitivity. Ang receptor blockers (ARBs) modulate peroxisome proliferator-activated (PPAR)-γ activity. PPAR–γ transcription factor controls gene expression several enzymes glucose metabolism. A further mechanism accounts for favorable properties ARBs capability hypothalamic–pituitary-adrenal (HPA) axis. available clinical consistent concept both able IR its consequences like type 2 diabetes. addition, inhibition RAAS has favourable effects on dyslipidaemias, syndrome obesity. Therefore, antagonism RAAS, nowadays, represents first choice prevention cardio-metabolic diseases.

Language: Английский

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