Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(12), P. e2324 - e2333

Published: Feb. 14, 2024

Abstract Context The association between magnesium status and metabolic syndrome (MetS) remains unclear. Objective This study aimed to examine the relationship kidney reabsorption-related depletion score (MDS) MetS among US adults. Methods We analyzed data from 15 565 adults participating in National Health Nutrition Examination Survey (NHANES) 2003 2018. was defined according Cholesterol Education Program's Adult Treatment Panel III report. MDS is a scoring system developed predict of deficiency that fully considers pathophysiological factors influencing kidneys' reabsorption capability. Weighted univariate multivariable logistic regression were used assess MetS. Restricted cubic spline (RCS) analysis conducted characterize dose-response relationships. Stratified analyses by sociodemographic lifestyle also performed. Results In both analyses, higher significantly associated with increased odds Each unit increase approximately 30% risk for MetS, even after adjusting confounding (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted linear across range. positive correlation remained consistent various population subgroups exhibited no significant interaction age, sex, race, adiposity, smoking status, or alcohol consumption. Conclusion Higher urinary loss as quantified may be an independent factor adults, irrespective behavioral factors. Optimizing nutritional could potentially confer benefits patients

Language: Английский

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Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders

Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 682, P. 1 - 20

Published: Sept. 29, 2023

Language: Английский

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Assessment of TyG Index and Modified TyG Indices in Type 2 Diabetes Mellitus: Evaluating Their Potential as Predictors of Glycemic Control

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Introduction The triglyceride glucose (TyG) index and modified TyG-indices have been suggested as a reliable indication of insulin resistance. present study aimed to investigate the predictive utility TyG indices (TyG-waist circumference, TyG-body mass index, TyG-waist-to-hip ratio, TyG-waist-to-height ratio) for assessing glycemic control in type 2 diabetes mellitus (T2DM). Methods hospital-based cross-sectional recruited 383 T2DM patients. On basis HbA1c levels, patients were grouped into poor (n=168) good (n=215). Baseline biochemical parameters including compared between groups. We used Spearman correlation analysis look an association TyG-related control. conducted receiver operating characteristic curve evaluate capability TyG-index T2DM. Results with had significantly elevated when those showed strong individuals exhibited greater capacity indices. Conclusion Patients who are treated clinical settings limited resources may benefit from using their

Language: Английский

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Anti-hepatopathy and anti-nephropathy activities of Taraxacum officinale in a rat model of Streptozotocin diabetes-induced hepatorenal toxicity and dyslipidemia via attenuation of oxidative stress, inflammation, apoptosis, electrolyte imbalances, and mitochondrial dysfunction

Aspects of Molecular Medicine, Journal Year: 2024, Volume and Issue: 3, P. 100034 - 100034

Published: Feb. 15, 2024

Diabetes and chronic liver kidney disease are common long-term conditions worldwide. Taraxacum officinale (TOE) has many medicinal properties, due to it phytochemicals constitutions. This study investigate activities of TOE in Streptozotocin diabetes-Induced Hepatorenal toxicity. Sixty rats were randomized into groups A, B, C, D, E, F ten each (n = 10). Group normal control, group B treated with TOE, C diabetic (DM) negative D DM E metformin (MF)], follow by STZ-diabetic). Serum lipid profile, alanine transaminase (ALT), aspartate (AST), alkaline phosphatase (ALP), Gamma-glutamyl transferase (GGT), total proteins (TP), albumin (ALB), Urea, creatinine, electrolyte, oxidative antioxidant enzymes, caspase 3, inflammatory cytokines, tricarboxylic acid (TCA) cycle enzymes mitochondrial membrane potential (ΔΨm), histology investigated. Treatment ameliorated all the electrolyte disruptions rats. + MF recovered makers, Moreover, an increase hepatic renal functional markers, ALT, AST, ALP, GGT, TP, ALB, TCA respiratory-chain complexes (I-IV) ΔΨm a decrease creatinine clearance was treatment. protected against histological damage group. toxicity effectively administration. might be considered as protective agent hepatorenal

Language: Английский

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A randomized multi-arm open labelled comparative clinical trial report of Pankajakasthuri DiabetEaze powder, a novel polyherbal formulation on the nutritional management and glycemic control in type 2 diabetic and prediabetic patients

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42631 - e42631

Published: Feb. 1, 2025

Language: Английский

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Assessing the Vitamin-D (Calciferol) Supplementation Impact on Glycemic Levels among Patients with Type-2 Diabetes (DM-2); A Quasi-Experimental Trial

Journal of Islamabad Medical & Dental College, Journal Year: 2025, Volume and Issue: 13(4), P. 631 - 637

Published: Jan. 6, 2025

Background: Calciferol has vital role in maintenance of glucose levels by its action on VDR receptors which are located beta cells the pancreas after that leading to surge insulin secretion as well improvement sensitivity offered an increased expression Objective: To determine effect Vitamin-D (calciferol) control blood (measured terms mean reduction ≥1 HbA1c) calciferol deficient and insufficient diabetics, who have poorly controlled DM-2 Methodology: A Quasi-Experimental trial at Department Medicine, Fauji Foundation Hospital, Rawalpindi for 06 months was conducted after, meeting inclusion exclusion criteria. 115 patients were enrolled assessed measuring HbA1c levels, pre-& post supplementation. Results: Results showed ages 57.80 ± 7.64 years, 39(33.91%) male 76(66.09%) females. On pre-intervention, HbA1C participated 7.99 0.48 while post-intervention 7.97 (p-value=0.7523). Conclusion: Effect glycemic calciferol-deficient diabetics insignificant. Therefore, vitamin D supplementation appears no diabetes individuals low calciferol—both inadequate deficient—both low. Keywords: (Vitamin-D), Levels sugar, Poorly Controlled Type-2 Diabetes

Language: Английский

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Vitamin D Deficiency Meets Hill’s Criteria for Causation in SARS-CoV-2 Susceptibility, Complications, and Mortality: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 599 - 599

Published: Feb. 6, 2025

Clinical trials consistently demonstrate an inverse correlation between serum 25-hydroxyvitamin D [25(OH)D; calcifediol] levels and the risk of symptomatic SARS-CoV-2 disease, complications, mortality. This systematic review (SR), guided by Bradford Hill’s causality criteria, analyzed 294 peer-reviewed manuscripts published December 2019 November 2024, focusing on plausibility, consistency, biological gradient. Evidence confirms that cholecalciferol (D3) calcifediol significantly reduce hospitalizations, mortality, with optimal effects above 50 ng/mL. While vitamin requires 3–4 days to act, shows within 24 h. Among 329 trials, only 11 (3%) showed no benefit due flawed designs. At USD 2/patient, D3 supplementation is far cheaper than hospitalization costs more effective standard interventions. SR establishes a strong relationship 25(OH)D vulnerability, meeting criteria. Vitamin infections, deaths ~50%, outperforming all patented, FDA-approved COVID-19 therapies. With over 300 confirming these findings, waiting for further studies unnecessary before incorporating them into clinical protocols. Health agencies scientific societies must recognize significance results incorporate prophylaxis early treatment protocols similar viral infections. Promoting safe sun exposure adequate communities maintain 40 ng/mL (therapeutic range: 40–80 ng/mL) strengthens immune systems, reduces hospitalizations deaths, lowers healthcare costs. When exceed 70 ng/mL, taking K2 (100 µg/day or 800 µg/week) alongside helps direct any excess calcium bones. The recommended dosage (approximately IU/kg body weight non-obese adult) 50–100 cost-effective disease prevention, ensuring health outcomes.

Language: Английский

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Vitamin D and Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Implications—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2153 - 2153

Published: Feb. 27, 2025

Vitamin D has been widely studied for its implications on type 2 diabetes mellitus, a chronic condition characterized by insulin resistance, inflammation, and metabolic dysfunction. This review explores the molecular mechanisms underpinning vitamin D's effects glucose metabolism, adipogenesis, while assessing potential clinical applications in diabetes. In 1,25-dihydroxyvitamin D3 form, modulates various processes, affecting proinflammatory cytokines activating AMPK pathway, inhibiting mTOR signaling, promoting adipocyte differentiation. These enhance sensitivity reduce key contributors to this context, progression of prediabetes linked D, which limits pathological increases likelihood restoring normal state, crucial progression. Moreover, reported developing 15%, particularly doses higher than traditional recommendations bone health. Despite promising evidence, discrepancies study designs, serum measurements, population-specific factors highlight need standardized methodologies personalized approaches. conclusion, complementary therapeutic treating diabetes, revealing gaps research, such as optimal dosing long-term across populations. Future studies should integrate insights into practice optimize impact

Language: Английский

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Hypomagnesemia induces impaired glucose metabolism and insulin resistance in patients with Gitelman syndrome

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112160 - 112160

Published: March 1, 2025

Language: Английский

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Risk factors for suboptimal glycemic control in pediatrics with type 1 diabetes mellitus: a cross-sectional study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 29, 2024

Abstract The objective of this research is to analyze the influence various factors on glycemic control in pediatrics with type 1 diabetes mellitus (T1DM). study, a cross-sectional analysis, involved 221 T1DM patients below 18 years old who visited our clinic between 2011 and 2020, predating COVID-19 outbreak. Out initial pool, 204 participants were chosen based specific criteria. By computing odds ratios 95% confidence intervals, we determined correlation these achieving optimal (HbA1c < 7.5%). Of individuals, 55.9% (113 patients) female. average age at diagnosis was 6.93 ± 3.9 years. Mean HbA1c (A1C) level suboptimal groups 6.97, CI 6.84 7.1 8.86, 8.68 9.03, respectively (p-value 0.001). Fifty had 154 people experienced during follow-up that prevalence each them 24.51, 18.7 31 75.49, 68.99 81.22, respectively. In assessment risk associated control, aged 10–14 highest likelihood experiencing (crude ratio [COR] 3.12, 1.04 9.3), followed by duration (COR 2.85, 1.2 6.8), which both significant. utilizing multivariable logistic regression noteworthy finding emerged. It revealed exhibited significant association [adjusted (AOR) 4.85, 1.32 17.7]. Additionally, statistically identified individuals body mass index (BMI) falling within ≥ 95th percentile category Cramer’s V = 0.21, p-value 0.01. Our has obese (BMI 95th) control. crucial consider as they can offer valuable insights diagnosis, highlighting increased long-term

Language: Английский

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