Continuous Glucose Monitoring—New Diagnostic Tool in Complex Pathophysiological Disorder of Glucose Metabolism in Children and Adolescents with Obesity DOI Creative Commons
Marko Šimunović, Marko Kumrić, Doris Rušić

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2801 - 2801

Published: Dec. 13, 2024

Obesity is one of the leading causes chronic diseases, and its prevalence still rising in children adolescent populations. Chronic cardiovascular complications result metabolic syndrome (MS) type 2 diabetes mellitus. Key factors development MS are insulin resistance low-grade inflammation. The disorder glucose metabolism has not been fully elucidated so far, an oral tolerance test (OGTT) only tool used to look into complex adolescents with obesity. Continuous monitoring (CGM) become commercially available for over two decades primarily manage 1 mellitus pediatric This review aims present current knowledge about use CGM populations systems have potential serve as valuable tools everyday clinical practices, better diagnosis associated obesity, but can also assist interventions make adjustments nutritional therapeutic approaches based on real-time data. Despite these promising benefits, further research needed understand role disorders which will additionally strengthen importance practices.

Language: Английский

Correlation between Chinese visceral adiposity index and serum uric acid levels in type 2 diabetes mellitus patients DOI Creative Commons

Swailla Amina Araújo Intchasso Adotey,

Qian Zhang,

Mengxue Chen

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Purpose The Chinese Visceral Adiposity Index (CVAI), a measure of visceral adiposity dysfunction, is used to assess fat (VFA) malfunction. This research was performed evaluate the relationship between CVAI and serum uric acid levels in type 2 diabetes mellitus (T2DM) patients. Methods A total 2268 patients with T2DM were enrolled this study. We collected general clinical information patients, measured basic anthropometric indicators, tested glycolipid metabolism biochemical subcutaneous area bioelectrical impedance technology. According quartiles CVAI, classified into four groups: group (CVAI ≤ 94.43), B (94.43<CVAI 118.75), C (118.75<CVAI 143.95), D (CVAI≥143.95), each has 567 participants. Participants divided hyperuricemia (HUA) non-HUA groups, data two groups compared. Results Among as increased, proportion HUA gradually increased. correlation analysis showed that majority basal measures, indicators positively correlated CVAI. By comparison, level significantly higher than group. Meanwhile, through using ROC curve, our study observed more predictive value other obesity for HUA. Conclusion simple but effective indicator, which can reflect incidence As risk Therefore, we should pay attention application T2DM.

Language: Английский

Citations

1
Oxidative Stress Induced by Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) Dysfunction Aggravates Chronic Inflammation Through the NAD+/SIRT3 Axis and Promotes Renal Injury in Diabetes DOI Creative Commons

Runyuan Li,

Xiaoyu Yan, Yuanxin Zhao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 267 - 267

Published: Feb. 25, 2025

Diabetic nephropathy (DN), one of the most common and severe microvascular complications diabetes, significantly increases risk renal failure cardiovascular events. A high-glucose environment can lead to mitochondrial dysfunction in macrophages, which, through remodeling energy metabolism, mediates polarization a pro-inflammatory phenotype contributes formation chronic inflammatory microenvironment. Recent studies have found that stimulation induces dysregulation nuclear factor erythroid 2-related 2 (NRF2) redox pathway leading generation oxidative stress (OS) further drives inflammation. Therefore, it is crucial fully understand how OS affects macrophage phenotypes functions following NRF2 inhibition. This review analyzes role induced by inflammation DN explores relationship between metabolism NAD⁺/NADH-SIRT3 axis, providing new therapeutic targets for targeting improve microenvironment vascular damage DN.

Language: Английский

Citations

1
Chemerin in Participants with or without Insulin Resistance and Diabetes DOI Creative Commons
Lei Zhao, Jonathan Zhou, Fahim Abbasi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 924 - 924

Published: April 22, 2024

Chemerin is a chemokine/adipokine, regulating inflammation, adipogenesis and energy metabolism whose activity depends on successive proteolytic cleavages at its C-terminus. levels processing are correlated with insulin resistance. We hypothesized that chemerin would be higher in individuals type 2 diabetes (T2D) those who resistant (IR). This hypothesis was tested by characterizing different forms specific ELISA the plasma of 18 participants T2D 116 without also had their resistance measured steady-state glucose (SSPG) concentration during an suppression test. approach enabled us to analyze association direct measure (SSPG concentration). Participants were divided into groups based degree using SSPG tertiles: sensitive (IS, ≤ 91 mg/dL), intermediate IR (IM, 92–199 ≥ 200 mg/dL). Levels highest patients T2D, second IR, lowest persons IM or IS. In whole group, positively both concentration) adiposity (BMI). most chemerin, resulting cleaved degraded chemerin. suggests increased inflammation have causes more processing.

Language: Английский

Citations

5
Global trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis DOI Open Access

Fang-Shuo Zhang,

H. Li, Xue Yu

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack effective treatment strategies, substantial socioeconomic burdens, it has become urgent public health issue that requires management resolution. Adolescent T2DM differs from adult T2DM. Despite significant increase in our understanding youth-onset over the past two decades, related review evidence-based content remain limited. AIM To visualize hotspots trends pediatric adolescent research forecast their future themes. METHODS This study utilized terms “children”, “adolescents”, “type diabetes”, retrieving relevant articles published between 1983 2023 three citation databases within Web Science Core Collection (SCI, SSCI, ESCI). Utilizing CiteSpace VoSviewer software, we analyze visually represent annual output literature, countries involved, participating institutions. allows us predict this field. Our analysis encompasses co-cited authors, journal overlays, time-zone views, keyword analysis, reference etc. RESULTS A total 9210 were included, publication volume field showed steady growth trend. The United States had highest number publications H-index. also most institutions strongest capacity. global hot journals primarily professional but included nutrition, endocrinology, metabolism. Keyword endothelial dysfunction, exposure risk, cardiac metabolic changes gut microbiota, impact on comorbidities outcomes, etc., emerging keywords. They have maintained popularity field, suggesting these areas garnered interest recent years. CONCLUSION Pediatric is increasingly drawing attention, with genes, behaviors, environmental factors, multisystemic interventions potentially as spots.

Language: Английский

Citations

3
Placental Weight as a Predictor of Future Health: Insights from a Large-scale Genome-wide Association Study DOI
Qinyi Zhang,

Tianhan Xu,

Sihui Yu

et al.

Placenta, Journal Year: 2025, Volume and Issue: 164, P. 10 - 20

Published: March 12, 2025

Language: Английский

Citations

0
Metabolic reprogramming of macrophages in the context of type 2 diabetes DOI Creative Commons

Leonel Witcoski,

Jordana Dinorá de Lima,

Amanda Girardi Somensi

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 16, 2024

Type 2 diabetes (T2D) is associated with insulin resistance and progressive dysfunction of β-pancreatic cells, leading to persistent hyperglycemia. Macrophages play a crucial role in this context, influencing both the development progression resistance. These innate immune cells respond inflammatory stimuli reprogram their metabolism, directly impacting pathophysiology T2D. are highly plastic can adopt either pro-inflammatory or pro-resolutive phenotypic profiles. In T2D, macrophages, which rely on glycolysis, exacerbate through increased production cytokines nitric oxide. contrast, prioritize fatty acid have different effects glucose homeostasis. Metaflammation, chronic low-grade inflammation, induced by macrophages significantly contributes creating an environment conducive metabolic dysfunction. This review aims clarify contribution T2D detailing how responses reprogramming influence disease's pathophysiology. The seeks deepen understanding biochemical mechanisms involved, offering broader insights into impact quality life for millions patients worldwide.

Language: Английский

Citations

2
Identification and validation of diagnostic genes associated with neutrophil extracellular traps of type 2 diabetes mellitus DOI Creative Commons
Meifang He,

Jin Niu,

Haihua Cheng

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

Neutrophil extracellular traps (NETs) cause delayed wound closed up in type 2 diabetes mellitus (T2DM), but the specific regulatory mechanism of NETs-related genes (NETs-RGs) T2DM is unclear.

Language: Английский

Citations

0
Continuous Glucose Monitoring—New Diagnostic Tool in Complex Pathophysiological Disorder of Glucose Metabolism in Children and Adolescents with Obesity DOI Creative Commons
Marko Šimunović, Marko Kumrić, Doris Rušić

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2801 - 2801

Published: Dec. 13, 2024

Obesity is one of the leading causes chronic diseases, and its prevalence still rising in children adolescent populations. Chronic cardiovascular complications result metabolic syndrome (MS) type 2 diabetes mellitus. Key factors development MS are insulin resistance low-grade inflammation. The disorder glucose metabolism has not been fully elucidated so far, an oral tolerance test (OGTT) only tool used to look into complex adolescents with obesity. Continuous monitoring (CGM) become commercially available for over two decades primarily manage 1 mellitus pediatric This review aims present current knowledge about use CGM populations systems have potential serve as valuable tools everyday clinical practices, better diagnosis associated obesity, but can also assist interventions make adjustments nutritional therapeutic approaches based on real-time data. Despite these promising benefits, further research needed understand role disorders which will additionally strengthen importance practices.

Language: Английский

Citations

0