The Role of Systemic Health Indicators, Including C-Reactive Protein and eGFR, in Predicting Periodontal Disease: A Longitudinal Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 741 - 741

Published: Jan. 16, 2025

C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) are key biomarkers reflecting systemic inflammation metabolic dysfunction. This study explored oral health indicators, including CRP eGFR, as potential factors associated with periodontitis, using a longitudinal clinical dataset comprising 23,742 records from patients identified by ICD-10 codes between 2015 2022. Univariate Cox analysis Gompertz models, selected based on AIC BIC after evaluating alternative were employed to assess the predictive roles of eGFR in periodontitis incidence, adjusting for factors. Elevated (>15 mg/L) reduced (<60 mL/min/1.73 m2) significant predictors hazard ratios (HR) 1.36 [1.05–1.77] 1.39 [1.08–1.78], respectively. Atherosclerosis (HR: 2.12 [1.11–4.06]), diseases hard tissues teeth 7.30 [5.45–9.78]), disorders supporting structures 3.02 [2.05–4.43]) also demonstrated strong associations. emerged predicting enabling early interventions prevent tooth loss complications. Patients chronic kidney disease, atherosclerotic heart lipid metabolism at higher risk, emphasizing need integrated care addressing both

Language: Английский

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The influence of chronic periodontitis and type 2 diabetes mellitus on resistin levels of gingival crevicular fluid- a systematic review and meta-analysis

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(3), P. 612 - 623

Published: April 8, 2025

Language: Английский

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Effect of Periodontal Treatment in Patients with Periodontitis and Diabetes: Review of Systematic Reviews with Meta-Analyses in the Last Five Years

Healthcare, Journal Year: 2024, Volume and Issue: 12(18), P. 1844 - 1844

Published: Sept. 14, 2024

Background: Periodontitis is a chronic infectious–inflammatory pathology, with high prevalence, which destroys the dental support and, if left untreated, leads to tooth loss. It associated other pathologies, particularly diabetes mellitus. Objectives: Our objective was conduct review of systematic reviews meta-analyses determine evidence for periodontal treatment on periodontitis and diabetes. Second, we assessed risk bias methodological quality using AMSTAR-2 ROBIS tools. Methods: We performed bibliographic searches in PubMed/Medline, Embase, Cochrane Central, Dentistry & Oral Sciences Source databases Web Science (WOS) scientific information service identify from last five years. Results: Eighteen studies that met inclusion criteria evaluated 16,247 subjects were included. The most studied parameters probing pocket depth, clinical attachment level, bleeding glycated hemoglobin. Most included adult patients type 2 mellitus (T2DM). considered by showed significant errors. domain worst assessment tool. Conclusions: Despite weaknesses terms bias, DM appear contribute improved outcomes bidirectional manner between DM.

Language: Английский

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Insight of the interrelationship and association mechanism between periodontitis and diabetes mellitus

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1159 - 1167

Published: June 1, 2024

Periodontitis and diabetes mellitus are two prevalent chronic diseases that have been recognized to exhibit a bidirectional relationship. Individuals with more susceptible periodontitis, conversely, periodontitis can exacerbate glycemic control in diabetic patients. The underlying mechanisms of this interrelationship involve complex pathways, including inflammatory responses, altered immune functions, microbial dysbiosis. mechanistic insights into the between revolve around role inflammation as common link diseases. Inflammatory mediators such cytokines, chemokines, prostaglandins play crucial pathogenesis progression dysregulation response leading increased tissue destruction bone resorption. contribute insulin resistance impaired Future directions research aim further elucidate molecular mellitus. Modulating response, restoring balance, improving hold promise managing both conditions simultaneously. Herein, we will provide an overview mellitus, retrospect mechanisms, which may inspire investigators directions.

Language: Английский

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Direct impact of psoriasis on gingival crevicular fluid levels of VEGF-A in periodontitis patients: a mediation analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

Emerging evidence suggests that psoriasis and periodontitis are linked via systemic inflammation. However, the role of angiogenesis as an additional connecting mechanism between these diseases remains unclear.

Language: Английский

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