Metabolic outcomes of bariatric surgery versus lifestyle intervention in adolescents with severe obesity: A systematic review and meta‐analysis

Clinical Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Data from clinical trials evaluating the effectiveness and safety of metabolic bariatric surgery (MBS) compared to lifestyle modifications (LSM) in children adolescents with obesity are scarce. This systematic review meta-analysis (SRM) sought fill this knowledge gap. Randomised or non-randomised spanning at least one-year involving severe receiving any form MBS intervention group LSM for weight loss control were systematically searched through electronic databases. SRM adhered guidelines outlined Cochrane Handbook Systematic Reviews Interventions PRISMA checklists. The primary outcome interest was change body baseline. Five (three randomised, open-label two non-randomised) 1-2 years follow-up durations analysed, including 367 participants aged 10-19 years. resulted greater reductions (mean difference [MD] -25.83 kg, 95% confidence interval [CI] [-36.91, -14.75], p < .00001) per cent (MD -24.54%, CI [-33.19, -15.89], LSM. Furthermore, outperformed reducing mass index (BMI), BMI z-score, waist circumference, glycated haemoglobin, fasting plasma glucose, insulin resistance, triglycerides, alanine aminotransferase, high sensitivity C-reactive protein an overall improvement physical functioning quality life. profile comparable between groups; however, data Larger, longer-term that include multinational multiethnic representation essential making solid practice recommendations regarding obesity.

Language: Английский

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Double Diabetes: A Converging Metabolic and Autoimmune Disorder Redefining the Classification and Management of Diabetes

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

This review explores the pathophysiology, clinical implications, and management of double diabetes. The increasing prevalence obesity, sedentary lifestyles, genetic predisposition has blurred difference between type 1 2 diabetes, leading to diagnostic therapeutic challenges. Double diabetes presents with overlapping symptoms from both types, making accurate diagnosis crucial. Biomarkers, such as C-peptide levels, autoantibody testing, insulin resistance markers, help differentiate classic subtypes. Early intervention is necessary because condition's elevated risk microvascular macrovascular consequences, retinopathy, nephropathy, cardiovascular disease. Effective integrates pharmacological lifestyle approaches. Metformin, sodium-glucose cotransporter (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, therapy adjustments all boost glycemic control metabolic results. Additionally, structured exercise, dietary modifications, weight are essential for reducing preserving beta-cell activity. potential precision medicine, artificial intelligence (AI)-driven healthcare, continuous glucose monitoring (CGM) offers promising advancements personalized treatment strategies. Future research should focus on targeted immunotherapies, profiling, refined guidelines improve early detection individualized treatment, long-term outcomes. emphasizes need a multidisciplinary approach in managing ensuring diagnosis, optimized improved health mitigate complications.

Language: Английский

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Prevalence of noncommunicable diseases and developmental conditions in 5014 Australian adolescents, and their correlations with diet, other lifestyle behaviours and mental health

Australian and New Zealand Journal of Public Health, Journal Year: 2025, Volume and Issue: unknown, P. 100225 - 100225

Published: April 1, 2025

Amongst Australian youth, there is currently a lack of understanding the prevalence noncommunicable diseases and developmental conditions links with modifiable lifestyle behaviours, mental health other socio-demographics. This paper aims to address this gap. adolescents (N = 5014, Mage=14.7, SD=0.80) completed self-report survey assessing diseases/developmental conditions, sex, socio-economic status (SES), behaviours health. Multivariable logistic regressions were used estimate associations between these variables. The moderating effects sex SES investigated by including interaction terms in each regression model. 45.6% reported ≥1 disease/developmental condition. Being female, consuming more sugar-sweetened beverages, ultra-processed foods, or alcohol, participating screen time, having depression, anxiety psychological distress associated higher rates at least one disease/condition (p<0.01). Sex significantly moderated some eight diseases/conditions examined. experience considerable highlighting significance public issue. Links highlight their potential importance assist prevention treatment common emerging adolescents.

Language: Английский

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Strategy of non-drug management of metabolic syndrome, which is accompanied by prediabetes and hypertension

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(2), P. 179 - 184

Published: April 1, 2025

Background. The condition of prediabetes implies the possibility to achieve stable normal glycemic indicators in order prevent further development diabetes without using drug therapy. effectiveness and safety herbal cardioprotectors metabolic syndrome accompanied by is being comprehensively studied all over world. purpose was determine study possibilities influence natural cardioprotector, on carbohydrate lipid metabolism, as well blood pressure patients with syndrome. Materials methods. Patients were divided into 3 groups: first one (control group), diet therapy physical activity prescribed, second third — therapy, cardioprotector different dosages. Fasting glucose glycated hemoglobin (HbA1C), lipidogram monitored, quality life index assessed before treatment, after 4 8 weeks. estimated sum points self-reported EQ-5D-5L questionnaire. Results. Conducted clinical observations three selected groups showed ability harmonize a tendency reach norm reduce fasting HbA1C. In group 2, which took 2 capsules medicine twice daily, there more pronounced shift towards normalization low- high-density lipoproteins, total cholesterol triglycerides. Also, this compared 1 control group, significant hypoglycemic effect recorded: decrease from 6.22 ± 0.13 5.22 0.08 mmol/l (р < 0.05), allows us reasonably assume existence certain dose-dependent cardioprotector. Conclusions. Herbal has shown non-medicinal correction manifestations and, all, prediabetes. Due high profile active ingredients remedy, practitioners can fully use potential non-pharmacological

Language: Английский

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Randomized controlled trials on physical activity, diet, or both for public health through body weight management in 5- to 10-year-old pupils: a systematic review and meta-analysis

European Journal of Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Improving the quality of most basic health behavior among youth may contribute to short-term body composition management with long-term implications for noncommunicable disease regression. This investigation aimed assess impact primary school physical activity (PA), dietary, or dual approach interventions on pupils’ weight (BW) and mass index (BMI). A systematic review meta-analysis was completed following a study protocol trial registration (PROSPERO: CRD4202347770) PRISMA approach. Publications in English German were included school-based randomized controlled trials diet and/or PA. Pupils schools (aged 5–10) no major nutritional deficiency unstable condition included. The Boolean search strategy revealed total 9479 articles, qualifying 39 studies 20 462 pupils (including 10 211 girls 251 boys) quantitative synthesis. mostly PA (n = 31), several dietary 6), some 5). Random effects meta-analyses intervention 20) have an effect size +0.07 kg (95% CI: −0.01 0.15) −0.12 kg/m2 −0.23 −0.01). Low statistical heterogeneity found BW (I2 0%; P 1.000) BMI .9688), respectively. findings indicate scarcity top-quality scientific research performed healthy schools. elementary provides support healthier profile amidst current world crisis.

Language: Английский

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Insulin Dynamics and Pathophysiology in Youth-Onset Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(10), P. 2411 - 2421

Published: July 3, 2024

Abstract Youth-onset type 2 diabetes (T2D) is increasing around the globe. The mounting disease burden of youth-onset T2D portends substantial consequences for health outcomes young people and care systems. pathophysiology this condition characterized by insulin resistance initial hypersecretion ± an inherent secretory defect, with progressive loss stimulated secretion leading to pancreatic β-cell failure. Research studies focusing on have illuminated key differences youth- vs adult-onset T2D, youth having more profound quicker progression sufficient maintain euglycemia. There a need therapies that are targeted improve both and, importantly, function over lifespan in T2D.

Language: Английский

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The Association of Weight Categories in Adolescence with Cardiovascular Morbidity in Young Adult Israeli Arabs—A Nationwide Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5382 - 5382

Published: Sept. 11, 2024

The health consequences of adolescent obesity are understudied in young adult Israeli Arabs. We aimed to evaluate the association weight categories during adolescence with hypertension (HTN), diabetes mellitus type 2 (DM2), and composite endpoint ischemic stroke (IS), myocardial infarction (MI), heart failure (HF) Arabs on a nationwide level.

Language: Английский

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Global strategies for preventing type 2 diabetes: A public health perspective

The Indian Journal of Medical Research, Journal Year: 2024, Volume and Issue: 160, P. 391 - 395

Published: Nov. 28, 2024

Language: Английский

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Bariatric surgery in children with obesity and type 2 diabetes

The Lancet Diabetes & Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Obesidade e Diabetes tipo 2 em crianças: epidemiologia e tratamento

Cuadernos de Educación y Desarrollo, Journal Year: 2024, Volume and Issue: 16(12 Edição Especial), P. e6511 - e6511

Published: Dec. 20, 2024

Introdução: A obesidade amplifica significativamente o quadro clínico da diabetes mellitus tipo 2 (DM2), tornando estas doenças uma sindemia crítica. No cenário pediátrico, a ocorrência simultânea de e DM2 tem aumentado níveis exponenciais. Tal indício merece atenção, vez que infantil progride mais rapidamente do em adultos, principalmente, quando atrelada um IMC elevado. Objetivo: Identificar, compreender discutir epidemiologia tratamento associada DM2. Metodologia: Consiste revisão integrativa literatura, realizada nas bases dados PubMed Scielo, publicados nos últimos 5 anos. Resultados discussão: Foram encontrados total 284 artigos. Posteriormente à aplicação dos critérios inclusão exclusão, 14 artigos foram incluídos neste estudo dada sua relevância. Os pacientes pediátricos obesos com alta prevalência hipomagnesemia fragilidade óssea. O farmacológico possui opções limitadas – metformina, insulina liraglutida. Conclusão: maioria das literaturas relata ambas as possuem mecanismos fisiopatológicos se conectam, são fortemente influenciado pelo fator ambiental. Ressalta-se importância estudos abordem acerca intervenções farmacológicas personalizadas, considerando idade, comorbidades associadas, para melhor inteirar temática proposta.

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