Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 224 - 224

Published: Sept. 23, 2024

Obstructive Sleep Apnea (OSA) is a prevalent disorder characterized by repetitive upper airway obstructions during sleep, leading to intermittent hypoxia and sleep fragmentation. Current treatments, particularly Continuous Positive Airway Pressure (CPAP), face adherence challenges, necessitating novel therapeutic approaches.

Language: Английский

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Tratamiento de la Apnea Obstructiva del Sueño en adultos: un análisis integral de las terapias convencionales y las innovaciones emergentes

MQRInvestigar, Journal Year: 2025, Volume and Issue: 9(1), P. e69 - e69

Published: Jan. 23, 2025

La apnea obstructiva del sueño (AOS) es un trastorno respiratorio caracterizado por obstrucciones recurrentes en las vías respiratorias superiores durante el sueño, causando hipoxemia, somnolencia diurna y despertares nocturnos. Afecta la calidad de vida puede originarse alteraciones anatómicas, neuromusculares o factores relacionados con estilo vida. Se asocia a enfermedades cardiovasculares, neurocognitivas metabólicas, además incrementar riesgo accidentes tráfico laborales. El objetivo investigar estrategias tratamiento empleadas para adultos, recalcando los enfoques convencionales mencionando innovaciones quirúrgicas emergentes. realizó una revisión literaria exhaustiva través bases datos electrónicas como Scopus, PubMed Web of Science. Los términos implementados incluyeron “apnea sueño”, “tratamiento presión positiva continua (CPAP)”, “cirugías palatinas nasales”, “dispositivos avance mandibular”. Fueron analizados total 20 artículos seleccionados su relevancia rigor científico. AOS varía según paciente gravedad. CPAP estándar casos moderados graves, aunque uso presenta desafíos. En leve, dispositivos mandibular son opción. Modificar vida, evitando alcohol sedantes, promoviendo pérdida peso, esencial. Las cirugías, reducción cornetes, septoplastia uvulopalatofaringoplastia, mejoran respiratorias. Procedimientos ablación radiofrecuencia maxilomandibular efectivos específicos. estimulación nervio hipogloso telemedicina ofrecen opciones prometedoras monitoreo personalizado.En conclusión debe ser personalizado, considerando anatómicos, severidad preferencias paciente. Aunque siguen siendo clave, tecnológicas complejos. detección temprano esenciales prevenir complicaciones mejorar

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Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 607 - 620

Published: April 1, 2025

Insulin resistance (IR) plays a significant role in the development of obstructive sleep apnea (OSA). The metabolic score for insulin (METS-IR) is novel method assessing IR. This study aims to explore relationship between METS-IR and risk OSA. cross-sectional included total 8297 subjects from NHANES (National Health Nutrition Examination Survey) database, as well 581 patients who underwent monitoring Renmin Hospital Wuhan University. Logistic regression, subgroup analysis, receiver operating characteristic (ROC) curve analysis were employed evaluation. In American population, positive association was found increased For each unit increase METS-IR, OSA by 4.4% (OR= 1.044; 95% CI: 1.037-1.059; P <0.001). A similar observed Chinese population. Multivariate regression model showed that prevalence 6.7% 1.067; 1.035-1.103; <0.001), apnea-hypopnea index (AHI) 0.732 (β= 0.732; 0.573-0.732; Gender further particularly male participants 1.111; 1.065-1.163; ROC area under (AUC) value predicting 0.777, but it not statistically significantly different triglyceride glucose (TyG) (AUC = 0.749; 0.054), body mass (BMI) 0.769; 0.269), glucose-body (TyG-BMI) 0.777; 0.996). associated with may serve an effective predictive marker identifying

Language: Английский

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Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

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Magnesium is a key trace element in obstructive sleep apnea: evidence from Mendelian randomization analysis and NHANES database

Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 108158 - 108158

Published: May 1, 2025

Language: Английский

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Causal association of lifestyle factors, clinical features in the risk of sleep disorders: Based on mendelian randomization analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Objective: To identify potential genetic risk factors for sleep disorders (SD) and to explore the causal associations between lifestyle clinical features with SD, given limitations of traditional observational studies. Methods: Data from published genome-wide association studies (GWAS) were analyzed, encompassing 34 17 as exposures influencing SD. These analyses yielded information on 51 4 outcomes. Outcomes consisted four categories: non-organic (NSD), narcolepsy, rapid eye movement (REM) behavior (RSBD), obstructive apnea (OSA). All variables exposure outcome derived individuals European ancestry. Two-sample MR analysis was conducted, inverse variance weighted (IVW) primary method evaluating effects. Weighted median estimation (WME), MR-Egger (MRE), simple mode (SM), (WM) used supplementary evaluation methods. Results: (1) The protective causally associated NSD include overall physical activity time (OR: 0.35; 95%CI: 0.13-0.99; P=0.048) fresh fruit intake 0.30; 0.12-0.75; P=0.010). (2) that are related narcolepsy smoking 1.02; 1.01-1.03; P=0.001), alcoholic drinks P=0.013 OR: P<0.001), cereal 1.03; 1.00-1.07; P=0.029), salad/raw vegetable 1.10; 1.03-1.16; P=0.002), TDI 1.05; 1.00-1.10; P=0.036), health rating 1.07; 1.05-1.10; BMI 1.02-1.03; FINS 1.06; 1.03-1.09; P<0.001), TG P<0.001) hypertension 1.08; 1.02-1.15; P=0.011). (3) tea 0.95; 0.93-0.97; non-oily fish 0.91; 0.84-0.99; P=0.021), years schooling 0.97; 0.96-0.99; cognitive performance 0.98; 0.97-0.99; P=0.001), average total household income before tax 0.94; 0.93-0.96; ApoA-I 0.99; 0.99-1.00; HDL 0.98-0.99; P<0.001). (4) OSA 1.20; 1.08-1.34; P=0.001 1.15; 1.06-1.25; alcohol 1.12; 1.01-1.24; P=0.037), coffee 1.25; 1.00-1.56; P=0.046), pork 2.55; 1.37-4.74; P=0.003), 1.56; 1.12-2.19; P=0.009), 2.76; 2.20-3.46; 1.97; 1.85-2.11; WHR 1.30; 1.08-1.55; P=0.004), 1.02-1.11; 2.72; 1.73-4.26; CRP 1.01-1.11; P=0.016). (5) bread 0.63; 0.49-0.83; 0.71; 0.56-0.90; P=0.005), dried 0.64; 0.50-0.83; 0.72; 0.66-0.79; 0.79; 0.71-0.87; 0.78; 0.66-0.93; FPG 0.84; 0.75-0.94; P=0.003), 0.90-0.99; P=0.017) 0.89; 0.85-0.93; (6) After multivariate through adjusting BMI, ApoA-I, TG, still exists. Conclusions: evidence this study suggests among factors: NSD. Smoking drinks, intake, poverty, poor rating, high narcolepsy. Tea non oily education cognition, OSA. Bread Among features: is a factor High FINS, hypertension, FPG, There not enough suggest other relationships meet criteria established.

Language: Английский

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High Body Roundness Index Is Associated With Unhealthy Sleep Patterns: Insights From NHANES (2007–2014)

Brain and Behavior, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 31, 2024

Substantial evidence suggests an association between obesity and sleep. However, research investigating sleep patterns in relation to novel anthropometric indices is limited. Therefore, we conducted a cross-sectional analysis of data from the National Health Nutrition Examination Survey (NHANES) 2007 2014 examine relationship body roundness index (BRI) unhealthy patterns.

Language: Английский

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