Advancements in 3D Cell Culture Models for Drug Discovery and Disease Modeling DOI
Rea Barlas

Next frontier., Journal Year: 2024, Volume and Issue: 8(1), P. 203 - 203

Published: Nov. 28, 2024

The advent of 3D cell culture models has revolutionized drug discovery and disease modeling, offering more physiologically relevant systems compared to traditional 2D cultures. These advanced mimic the in vivo microenvironment, incorporating critical cellular interactions, extracellular matrix components, gradients oxygen nutrients. This research explores development application technologies, such as organoids, spheroids, bioprinted tissues, studying mechanisms evaluating efficacy. study highlights advantages these recapitulating complex biological processes, including tumor microenvironments, organ development, tissue-specific responses therapeutic agents. By employing cutting-edge techniques microfluidics, imaging, computational aims optimize for high-throughput screening personalized medicine. findings underscore transformative potential bridging gap between preclinical studies clinical outcomes, reducing costs improving patient-specific approaches.

Language: Английский

Bone Tissue Engineering: From Biomaterials to Clinical Trials DOI

Swapnali Jagadale,

Mrunal N. Damle, Meghnad G. Joshi

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhancing the clinical translation of stem cell models by focusing on standardization and international regulatory cooperation DOI
Wei Wang,

Anran Song,

Hong‐Wen Liu

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 21, 2025

The article by Granjeiro et al provided a thorough review of the role stem cell models in development advanced therapy medicinal products. It emphasized potential to refine preclinical studies and align with regulatory requirements for clinical applications. This introduced new perspective on enhancing transition research into practice, focusing importance international harmonization need standardization cell-based therapies.

Language: Английский

Citations

0
Advancements in 3D Cell Culture Models for Drug Discovery and Disease Modeling DOI
Rea Barlas

Next frontier., Journal Year: 2024, Volume and Issue: 8(1), P. 203 - 203

Published: Nov. 28, 2024

The advent of 3D cell culture models has revolutionized drug discovery and disease modeling, offering more physiologically relevant systems compared to traditional 2D cultures. These advanced mimic the in vivo microenvironment, incorporating critical cellular interactions, extracellular matrix components, gradients oxygen nutrients. This research explores development application technologies, such as organoids, spheroids, bioprinted tissues, studying mechanisms evaluating efficacy. study highlights advantages these recapitulating complex biological processes, including tumor microenvironments, organ development, tissue-specific responses therapeutic agents. By employing cutting-edge techniques microfluidics, imaging, computational aims optimize for high-throughput screening personalized medicine. findings underscore transformative potential bridging gap between preclinical studies clinical outcomes, reducing costs improving patient-specific approaches.

Language: Английский

Citations

0