Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury DOI
Jun Chang,

Xiu-Mei Yin,

Man Zhang

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

Peripheral nerve injury (PNI) is a common disease that difficult to regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting regeneration, revealing broad prospects for BMSCs transplantation alleviating PNI. We confirmed fact significantly alleviate PNI, but there are shortcomings such as low cell survival rate immune rejection, which limit wide application BMSCs. BMSCs-derived exosomes (Exos) considered promising cell-free nanomedicine avoiding ethical issues Exos combination bioengineering therapeutics (including extracellular matrix, hydrogel) brings new hope provides favorable microenvironment neurological restoration therapeutic strategy safety profile, increases expression neurotrophic factors, promotes axonal myelin demonstrates strong potential enhance neurogenesis. Therefore, engineered exhibit better properties, stronger targeting more beneficial components. This article briefly describes nanotechnology therapies proposes clinical challenges PNI improve efficacy treatment

Language: Английский

Priming mesenchymal stem cells to develop “super stem cells” DOI
Khawaja Husnain Haider

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(6), P. 623 - 640

Published: June 24, 2024

The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of cells to growth factor treatment, genetic manipulation, chemical pharmacological each strategy having advantages limitations. Most these protocols are non-combinative. This editorial is a continuum Li

Language: Английский

Citations

5
Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury DOI
Jun Chang,

Xiu-Mei Yin,

Man Zhang

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

Peripheral nerve injury (PNI) is a common disease that difficult to regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting regeneration, revealing broad prospects for BMSCs transplantation alleviating PNI. We confirmed fact significantly alleviate PNI, but there are shortcomings such as low cell survival rate immune rejection, which limit wide application BMSCs. BMSCs-derived exosomes (Exos) considered promising cell-free nanomedicine avoiding ethical issues Exos combination bioengineering therapeutics (including extracellular matrix, hydrogel) brings new hope provides favorable microenvironment neurological restoration therapeutic strategy safety profile, increases expression neurotrophic factors, promotes axonal myelin demonstrates strong potential enhance neurogenesis. Therefore, engineered exhibit better properties, stronger targeting more beneficial components. This article briefly describes nanotechnology therapies proposes clinical challenges PNI improve efficacy treatment

Language: Английский

Citations

0