World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 17, 2025
Peripheral nerve injury (PNI) is a common disease that difficult to regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting regeneration, revealing broad prospects for BMSCs transplantation alleviating PNI. We confirmed fact significantly alleviate PNI, but there are shortcomings such as low cell survival rate immune rejection, which limit wide application BMSCs. BMSCs-derived exosomes (Exos) considered promising cell-free nanomedicine avoiding ethical issues Exos combination bioengineering therapeutics (including extracellular matrix, hydrogel) brings new hope provides favorable microenvironment neurological restoration therapeutic strategy safety profile, increases expression neurotrophic factors, promotes axonal myelin demonstrates strong potential enhance neurogenesis. Therefore, engineered exhibit better properties, stronger targeting more beneficial components. This article briefly describes nanotechnology therapies proposes clinical challenges PNI improve efficacy treatment
Language: Английский