Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in Osteoporosis DOI Creative Commons

Rongjin Chen,

Chenhui Yang,

Fei Yang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1452 - 1452

Published: Nov. 15, 2024

Osteoporosis (OP) is a widespread age-related disorder marked by decreased bone density and increased fracture risk, presenting significant public health challenge. Central to the development progression of OP dysregulation mechanistic target rapamycin (mTOR)-signaling pathway, which plays critical role in cellular processes including autophagy, growth, proliferation. The mTOR-autophagy axis emerging as promising therapeutic due its regulatory capacity metabolism homeostasis. This review aims (1) elucidate mTOR signaling OP, (2) explore interplay between autophagy context cell activity, (3) assess potential targeting pathway with modulators innovative strategies for treatment. By examining interactions among mTOR, insights from various types impact on different cells, this underscores complexity mTOR's health. Despite advances, gaps remain understanding detailed mechanisms effects function, highlighting need comprehensive clinical trials establish efficacy safety inhibitors management. Future research directions include clarifying molecular investigating combined benefits modulation other approaches. Addressing these challenges crucial developing more effective treatments improving outcomes individuals thereby unveiling potentials prevalent disease.

Language: Английский

Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy DOI

Meng-Qin Guo,

Ping Hu,

Zhi-hong Huang

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Xiao et al reported on the natural product sinomenine (SIN), which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy; however, SIN was dissolved in dimethyl sulfoxide prior to administration, not conducive development clinical injectables. By comparing solubilization techniques, including amorphisation, emulsification, micellisation, nano-crystallisation and host-guest inclusion, we found that by inclusion can enhance solubility improve stability has an increased release rate enhanced bioavailability. Therefore, conclude holds promise solubilization. To solubilise SIN, selected β-cyclodextrin as host agent considering excellent biocompatibility, efficient encapsulation ability, mature preparation process adequate drug stability. If prerequisites SIN-β-cyclodextrin complexes terms safety, efficacy, relevant laws regulations are met, application treatment may be achieved.

Language: Английский

Citations

0
Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in Osteoporosis DOI Creative Commons

Rongjin Chen,

Chenhui Yang,

Fei Yang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1452 - 1452

Published: Nov. 15, 2024

Osteoporosis (OP) is a widespread age-related disorder marked by decreased bone density and increased fracture risk, presenting significant public health challenge. Central to the development progression of OP dysregulation mechanistic target rapamycin (mTOR)-signaling pathway, which plays critical role in cellular processes including autophagy, growth, proliferation. The mTOR-autophagy axis emerging as promising therapeutic due its regulatory capacity metabolism homeostasis. This review aims (1) elucidate mTOR signaling OP, (2) explore interplay between autophagy context cell activity, (3) assess potential targeting pathway with modulators innovative strategies for treatment. By examining interactions among mTOR, insights from various types impact on different cells, this underscores complexity mTOR's health. Despite advances, gaps remain understanding detailed mechanisms effects function, highlighting need comprehensive clinical trials establish efficacy safety inhibitors management. Future research directions include clarifying molecular investigating combined benefits modulation other approaches. Addressing these challenges crucial developing more effective treatments improving outcomes individuals thereby unveiling potentials prevalent disease.

Language: Английский

Citations

0