BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 17, 2024
The impact of prior SARS-CoV-2 infection on postoperative recovery patients who underwent liver resection for hepatocellular carcinoma (HCC) remains uncertain given the lack sufficient evidence.
Language: Английский
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 129 - 129
Published: Jan. 10, 2025
Free-of-charge hepatitis C virus antibody (HCV Ab) screening in some key populations and 1969-1989 birth cohorts have been funded Italy as the first step confirming diagnosis individuals who may be unaware of their infection. The purpose this study is to leverage existing in-hospital routine data better understand distribution HCV. A retrospective hospitalized patients (PTs) tested for HCV Ab 5 years (from January 2017 December 2022) San Raffaele hospital was conducted according age categories: year group before 1947 (patients older than 76 old), 1947-1968, 1969-1989, two other groups with 1990-2000 2001-2022 (with younger 33 old) using TriNetX platform. Among 42,805 PTs tested, 1297 (3.03%) were positive. prevalence greater over (5.3%), whereas it lower youngest cohort (2000-2022, 0.16%). positive PTs, only 198 (15.3%) presence RNA. had a modest seroprevalence (1.5%), yet they most affected group, 44.4% being RNA including 1947-1989 could more valuable option compared general population.
Language: Английский
Citations
0
Medicina Clínica, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)
Published: April 30, 2025
Individuals with severe liver disease are more vulnerable to COVID-19, but the association between chronic hepatitis B virus (HBV) infection and COVID-19 remains unclear. This study evaluates this relationship. We analysed nationwide Swedish data from national databases healthcare registers, identifying laboratory-confirmed cases February 2020 April 2021. Chronic HBV was classified into without cirrhosis. Multivariable logistic regression assessed adjusting for demographics, comorbidities, vaccination, socioeconomic factors. Among 1,057,174 cases, 2,902 had infection, which associated increased risk of (adjusted odds ratio [aOR] 1.242, 95% confidence interval [CI] 1.097-1.403). significantly higher in individuals cirrhosis (aOR 2.463, CI 1.546-3.892) compared those 1.183, 1.039-1.343). While overall mortality not elevated cohort, patients showed a higher, though nonsignificant, 2.350, 0.921-5.203). highlights an HBV, particularly Geographic factors further influence outcomes. These findings underscore need consider status assessments. Future studies should explore these associations context evolving SARS-CoV-2 variants widespread vaccination.
Language: Английский
Citations
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Medicina Clínica (English Edition), Journal Year: 2025, Volume and Issue: 164(9), P. 491 - 498
Published: May 1, 2025
Language: Английский
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Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(14), P. 4659 - 4659
Published: July 13, 2023
Statins have been widely advocated for use in COVID-19 based on large favorable observational associations buttressed by theoretical expected benefits. However, past of statins to pre-COVID-19 infection outcomes (also benefits) were unsupported meta-analysis RCTs, RR = 1.00. Initial RCTs appear follow this trajectory. Healthy-user/tolerator effects and indication bias may explain these disparities. Moreover, cholesterol drops proportion severity, so less severely affected individuals be selected statin use, contributing apparent outcomes. Cholesterol transports fat-soluble antioxidants immune-protective vitamins. impair mitochondrial function those most reliant coenzyme Q10 (a mevalonate pathway product also transported cholesterol)-i.e., with existing compromise, whom data suggest bear increased risks from both statins. Thus, adverse are amplified patients at risk poor outcomes-i.e., adjunctive therapy likely given. High reported rates rhabdomyolysis hospitalized underscore the notion that statin-related as well benefits must considered. Advocacy should suspended pending clear evidence RCT benefits, careful attention modifiers.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2212 - 2212
Published: Feb. 12, 2024
The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related diverse extrapulmonary manifestations this pathology. liver was found be a relatively common organ, beyond the respiratory tract, affected by severe acute syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed essential role chronic (CLD) in general outcome infection. Present concerns field are direct hepatic caused COVID-19 and pre-existing disorders as risk factors for course Which mechanism has key phenomenon—previously existing disorder or failure SARS-CoV-2—is still not fully clarified. Alcoholic (ALD) constitutes another elucidated context Should toxic effects ethanol already developed cirrhosis its perceived causative triggering factor impairment patients? In face these discrepancies, we decided summarize whole picture infection, paying special attention ALD focusing on pathological pathways COVID-19, toxicity cirrhosis.
Language: Английский
Citations
1
Published: Dec. 18, 2023
Free-of-charge HCV screening in some key populations and 1969–1989 birth cohorts have been funded Italy as the first step to diagnosing individuals unaware of their infection. The aim this study is use available in-hospital routine data understand inpatients a region North Italy. A retrospective search patients tested for HCV-antibody (HCV-Ab) from January 2017 end December 2022, was conducted according age categories (older than 76 years, group 1947-1968; group1969-1989 two other with younger 33 years) using TriNetX network. Of 42,805 tested, 1,297 (3.03%) resulted HCV-Ab positive. proportion decreased 2022 (from 2.03% 0.36%) years). higher prevalence older years (5.3%) while, lowest cohort (2000-2022, 0.16%). found positive, only 198 (15.3%) were presence RNA. Although 1969-1989 had lower seroprevalence (1.5%), they represented most affected 44.4% RNA positivity. including 1947-1989 could be valuable option respect general population. Since high not during hospitalization, reflex testing promptly ascertaining an active infection facilitate linkage care stop burden HCV.
Language: Английский
Citations
1
Medical alphabet, Journal Year: 2024, Volume and Issue: 34, P. 10 - 15
Published: Jan. 17, 2024
The COVID‑19 pandemic, first reported in late 2019, despite ending May 2023, continues to have a devastating impact on global health with significant associated morbidity and mortality rates. Liver injury is common feature patients ranges from mild temporary elevation of liver enzymes severe damage even acute failure. purpose this review present data the prevalence, pathophysiological mechanisms, clinical manifestations, diagnosis, course features, complications, treatment options for SARS-CoV‑2. Several mechanisms are responsible COVID‑19, including direct cytotoxic effect virus, cytokine storm, hypoxia ischemia organ, drug hepatotoxicity. Patients underlying chronic disease (CLD) (liver cirrhosis, non-alcoholic fatty disease, alcohol-related hepatocellular carcinoma, etc.) may greater risk develop both further deterioration. Some experience post-covid syndrome, also known as post-acute long-term or long COVID‑19. most manifestations syndrome pathology, developed directly connection SARS-Cov‑2 infection, people pre-existing CLD, include phenomena astheno-vegetative well biochemical signs moderate cytolysis cholestasis syndrome.
Language: Английский
Citations
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World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(1), P. 1 - 11
Published: Jan. 23, 2024
In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily targets the system, but evidence suggests extrapulmonary organ involvement, notably in liver. Viral RNA has been detected hepatic tissues, and situ hybridization revealed virions blood vessels endothelial cells. Electron microscopy confirmed viral particles hepatocytes, emphasizing need for understanding hepatotropism direct cytopathic effects COVID-19-related liver injury. Various factors contribute to injury, including cytotoxicity, vascular changes, inflammatory responses, immune reactions from COVID-19 vaccinations, drug-induced Although a typical hepatitis presentation is not widely documented, elevated biochemical markers are common hospitalized patients, showing hepatocellular pattern of elevation. Long-term studies suggest progressive cholestasis may affect 20% patients with chronic post-SARS-CoV-2 infection. The molecular mechanisms underlying SARS-CoV-2 infection resulting damage complex. This “Editorial” highlights expression Angiotensin-converting enzyme-2 receptor cells, role impact hypoxia, involvement liver's bile duct epithelial activation stellate contribution monocyte-derived macrophages. It also mentions that pre-existing conditions can worsen outcomes COVID-19. Understanding interaction still evolving, further research required.
Language: Английский
Citations
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Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 7, 2024
Language: Английский
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0