Foods,
Journal Year:
2024,
Volume and Issue:
13(13), P. 2014 - 2014
Published: June 26, 2024
:
Environmental
concerns
about
petroleum-based
plastic
packaging
materials
and
the
growing
demand
for
food
have
inspired
researchers
industry
to
develop
with
better
preservation
biodegradability.
Nanocomposites
consisting
of
nanofillers,
synthetic/biopolymers
can
be
applied
improve
physiochemical
antimicrobial
properties
sustainability
packaging.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 20, 2025
Nanotechnology
has
become
a
groundbreaking
innovation
force
in
cancer
therapy,
offering
innovative
solutions
to
the
limitations
of
conventional
treatments
such
as
chemotherapy
and
radiation.
By
manipulating
materials
at
nanoscale,
researchers
have
developed
nanocarriers
capable
targeted
drug
delivery,
improving
therapeutic
efficacy
while
reducing
systemic
toxicity.
Nanoparticles
like
liposomes,
dendrimers,
polymeric
nanomaterials
shown
significant
promise
delivering
chemotherapeutic
agents
directly
tumor
sites,
enhancing
bioavailability
minimizing
damage
healthy
tissues.
In
addition
with
utilization
tools
quantum
dots
nanosensors
that
enables
more
precise
identification
biomarkers,
nanotechnology
is
also
playing
pivotal
role
early
detection
diagnosis.
Furthermore,
nanotechnology-based
strategies,
including
photothermal
gene
therapy
immunotherapy
are
novel
ways
combat
by
selectively
targeting
cells
immune
response.
Nevertheless,
despite
these
progressions,
obstacles
still
persist,
particularly
clinical
translation
technologies.
Issues
nanoparticle
toxicity,
biocompatibility,
complexity
regulatory
approval
hinder
widespread
adoption
nanomedicine
oncology.
This
review
discusses
different
applications
highlighting
its
potential
hurdles
implementation.
Future
research
needs
concentrate
on
addressing
unlock
full
providing
personalized,
effective,
minimally
invasive
treatments.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 1, 2025
ABSTRACT
The
clinical
availability
of
photon‐counting
computed
tomography
(PCCT)
has
ushered
in
a
new
era
CT
imaging.
Spectral
imaging
coupled
with
superior
contrast
resolution,
and
ultrahigh
spatial
resolution
(200
μm)
offered
by
PCCT
the
potential
to
revolutionize
value‐driven
multicolor
generated
excitement,
renewed
interest,
novel
agent
development
for
comprehensive
disease
interrogation,
prediction
monitoring
treatment
outcomes.
Nanoparticles
provide
versatile
powerful
platform
next
generation
agents
spectral
PCCT.
In
this
article,
we
review
recent
developments
use
nanoparticle
We
also
discuss
future
research
translational
opportunities
nanoparticle‐based
enabled
advent
describe
key
considerations
their
translation.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(5), P. 703 - 703
Published: May 9, 2025
Nanotechnology
is
the
manipulation
of
matter
on
an
atomic
and
molecular
scale,
producing
a
lot
new
substances
with
properties
that
are
not
necessarily
easily
expected
based
present
knowledge.
produces
unique
can
be
beneficial
or
harmful
depending
their
biocompatibility
distribution.
Understanding
nanomaterial
toxicity
essential
to
ensure
safe
application
in
biological
environmental
applications.
This
review
aims
provide
comprehensive
overview
nanoparticle
toxicity,
focusing
physicochemical
properties,
mechanisms
cellular
uptake,
potential
health
risks.
Key
factors
influencing
include
particle
size,
shape,
concentration,
aspect
ratio,
crystallinity,
surface
charge,
dissolution,
agglomeration.
Nanoparticles
induce
oxidative
stress
inflammation,
contributing
adverse
effects
when
inhaled,
ingested,
applied
skin.
However,
may
limited
just
these
pathways,
as
they
also
exhibit
other
toxic
such
activation
apoptotic
pathway
mitochondrial
damage.
By
summarizing
current
knowledge
aspects,
this
article
intends
support
development
nanoparticles
safer
way
for
future
Thanks
to
their
simple
synthesis,
controlled
physical
properties,
and
minimal
toxicity,
iron
oxide
nanoparticles
(Fe
3
O
4
NPs)
are
widely
used
in
many
biomedical
applications
(bioimaging,
drug
delivery,
biosensors,
diagnostics,
theranostics,
etc.).
However,
the
use
of
NPs
does
not
preclude
possibility
some
selective
toxicity
undesirable
effects,
including
accumulation
tissues
direct
interaction
with
specific
biological
targets.
This
study
evaluated
biocompatibility
Fe
NPs,
Teucrium
polium
(
T.
polium)
extract,
rutin,
complexes
on
liver
tissue
healthy
white
Wistar
rats.The
impact
profile
synthesized
(15
±
nm),
biochemical
markers
function
(ALT,
AST,
ALP,
GGT,
HDL,
LDL,
total
cholesterol,
protein,
albumin)
morphological
indicators
rat
was
investigated.
extract
do
have
hepatotoxicity
when
administered
i/p
rats,
unlike
complexes.
All
agents
exert
a
hypolipidemic
effect
by
lowering
despite
maintaining
synthetic
functions
liver.
increase
activity
GPO,
which
is
associated
peroxidase-like
properties.
A
multifaceted
diverse
mechanism
action
all
studied
samples
rats
identified.
Journal of Community Pharmacy Practice,
Journal Year:
2024,
Volume and Issue:
45, P. 38 - 51
Published: Sept. 14, 2024
This
article
presents
the
spectrophotometric
determination
of
taiopronin
using
an
oxidative
coupling
reaction
with
dimethyl
phenylene
diamine.
The
UV-visible
method
was
developed
to
analyze
in
pure
drugs
and
pharmaceutical
formulations.
process
is
easy
use,
rapid,
accurate,
sensitive,
selective.
It
has
maximum
absorption
at
552
nm
wavelength.
involves
combination
a
drug
solution
reagent
oxidizing
agent,
resulting
purple
that
dissolved
water
exhibits
highest
specific
concentration
range
for
Beer's
law
5–30
μg/mL.
oxidation
conjugation
can
be
completed
two
minutes
25°C,
stable
value
hour.
high
accuracy,
linearity,
recall
rate
99.42%.
detection
limit,
quantitative
recovery
are
all
high,
demonstrating
its
precision
compatibility.
studies
generating
up
100%
relative
standard
deviation
less
than
2
demonstrated
how
accurate
precise
procedure
found
be,
indicating
excellent
results.
proposed
been
effectively
utilized
analyzing
preparations
contain
taiopronin.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 24013 - 24027
Published: Oct. 8, 2024
Microglia,
the
primary
immune
cells
of
central
nervous
system,
play
a
crucial
role
in
neuroinflammation
and
homeostasis.
They
can
adopt
either
M1
or
M2
phenotypes,
influencing
their
inflammatory
reparative
functions.
Modulating
microglia
phenotypes
functions
is
significant
area
therapeutic
interest.
However,
availability
delivery
vehicles
gene
expression
modulation
techniques
targeting
limited.
Fluorescent
quantum
dots
(Qdots)
are
semiconductor
nanoparticles,
specifically
used
to
label
modulate
offer
promising
alternatives
traditional
genome
editing
methods.
In
this
study,
we
developed
cadmium
selenide
(CdSe)
Qdot-mediated
system
target
microglial
genome.
We
evaluated
streptavidin-coated
CdSe
Qdots
for
ability
deliver
clustered
regularly
interspaced
short
palindromic
repeats-Cas9
vivo
vitro
assessed
distribution,
safety,
capacity
Cas9
ribonucleoproteins
(RNPs)
by
injecting
into
frontal
white
matter
cynomolgus
monkeys
Sprague–Dawley
rats.
Assessing
mechanisms
Qdot
uptake
stability
revealed
that
were
selectively
taken
up
microglia,
with
minimal
localization
other
cell
types.
Histological
biochemical
analyses
no
toxic
effects
following
injection.
The
did
not
interfere
RNP
efficiency
provided
enhanced
fluorescence
signals
microglia.
Cas9/Qdot
conjugates
stable
effectively
delivered
CRISPR-Cas9
demonstrating
higher
specificity
lower
cytotoxicity
when
compared
commercial
reagents.
conclusion,
nonviral
method
targeted
indicating
potential
applications
neuroinflammatory
neurodegenerative
diseases.
further
optimization
needed
improve
safety
clinical
applications.
