Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patients DOI

Manisha M Ratnaparkhi,

Chanda Vyawahare, Nageswari Gandham

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

Hepatitis B virus (HBV) infection is still a major worldwide health concern, contributing to chronic liver disorders like hepatocellular carcinoma (HCC). This review comprehensively analyzes HBV genotype distribution, mutation patterns, and their clinical implications, focusing on diagnostic therapeutic strategies for HBV-positive patients. The discussion begins with virology, emphasizing its capacity hepatitis association severe complications, notably HCC. Understanding genotypes (A-J) distinct geographic distributions crucial, as variations influence disease progression treatment responses. Genotypes C are particularly linked heightened HCC risk, highlighting the need genotype-specific management strategies. genomic structure of HBV, consisting four open reading frames (ORFs) encoding essential viral proteins, detailed, emphasis mutations within these ORFs influenced by host immune responses antiviral therapies. These contribute resistance virulence, impacting outcomes through alterations in replication dynamics. Clinical implications explored impacts approaches. Genotype analysis guide personalized regimens, optimizing efficacy while minimizing adverse effects preventing drug resistance. Diagnostic molecular techniques such polymerase chain reaction sequencing pivotal detection, facilitating tailored decisions.

Language: Английский

Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patients DOI

Manisha M Ratnaparkhi,

Chanda Vyawahare, Nageswari Gandham

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

Hepatitis B virus (HBV) infection is still a major worldwide health concern, contributing to chronic liver disorders like hepatocellular carcinoma (HCC). This review comprehensively analyzes HBV genotype distribution, mutation patterns, and their clinical implications, focusing on diagnostic therapeutic strategies for HBV-positive patients. The discussion begins with virology, emphasizing its capacity hepatitis association severe complications, notably HCC. Understanding genotypes (A-J) distinct geographic distributions crucial, as variations influence disease progression treatment responses. Genotypes C are particularly linked heightened HCC risk, highlighting the need genotype-specific management strategies. genomic structure of HBV, consisting four open reading frames (ORFs) encoding essential viral proteins, detailed, emphasis mutations within these ORFs influenced by host immune responses antiviral therapies. These contribute resistance virulence, impacting outcomes through alterations in replication dynamics. Clinical implications explored impacts approaches. Genotype analysis guide personalized regimens, optimizing efficacy while minimizing adverse effects preventing drug resistance. Diagnostic molecular techniques such polymerase chain reaction sequencing pivotal detection, facilitating tailored decisions.

Language: Английский

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