A cross-sectional study of Mpox Knowledge, Attitudes toward Mpox Vaccination and Mpox Vaccine Hesitancy Among Teachers in Kenya DOI Creative Commons
Mbuvi P. Mutua, Michael M. Gicheru, Joshua M. Mutiso

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Background: Sixteen African countries, including Kenya, reported mpox cases in July and August, prompting the Africa Centers for Disease Control to declare outbreak a Public Health Emergency of Continental Security on 13th August 2024. The World Organization issued an advisory mpox-related prevention schools whereby teachers are expected support mpox-infected students. There is dearth information knowledge attitudes toward vaccination among Kenya. Method: An online survey involving 1139 was conducted from 21st 3rd October, 2024 determine level vaccine hesitancy factors. Results: teachers’ mean score 8.2 out 12 whereas attitude 3.7 6. At time survey, more than 34 % respondents were not aware country. rate 49.78 %. More 62 participants cited concerns about side effects as main reason hesitancy. However, with certificate diploma likely accept be vaccinated against mpox. Only 1.23 received Teachers Service Commission. This study identifies gaps vaccination. It suggests that collaboration between Commission healthcare providers can ensure effective school community-based strategies by improving

Language: Английский

Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo DOI Creative Commons

Emmanuel Hasivirwe Vakaniaki,

Cris Kacita, Eddy Kinganda-Lusamaki

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(10), P. 2791 - 2795

Published: June 13, 2024

Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover clade I virus (MPXV) in Central Africa and II MPXV West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological genomic features an mpox outbreak mining region eastern Democratic Republic Congo, by MPXV. Surveillance data collected between September 2023 January 2024 identified 241 suspected cases. Genomic analysis demonstrates distinct lineage divergent previously circulating strains Congo. Of 108 polymerase chain reaction-confirmed cases, median age individuals was 22 years, 51.9% were female 29% sex workers, suggesting potential role for transmission. The predominance APOBEC3-type mutations estimated emergence time around mid-September imply recent sustained human-to-human

Language: Английский

Citations

153
Mpox respiratory transmission: the state of the evidence DOI Creative Commons
Amy Beeson, Ashley Styczynski, Christina L. Hutson

et al.

The Lancet Microbe, Journal Year: 2023, Volume and Issue: 4(4), P. e277 - e283

Published: March 7, 2023

The relative contribution of the respiratory route to transmission mpox (formerly known as monkeypox) is unclear. We review evidence for monkeypox virus (MPXV), examining key works from animal models, human outbreaks and case reports, environmental studies. Laboratory experiments have initiated MPXV infection in animals via routes. Some animal-to-animal has been shown controlled studies, sampling studies detected airborne MPXV. Reports real-life demonstrate that associated with close contact, although it difficult infer acquisition individual so far not specifically implicated. Based on available evidence, likelihood human-to-human appears be low; however, should continue assess this possibility.

Language: Английский

Citations

75
Sustained Human Outbreak of a New MPXV Clade I Lineage in Eastern Democratic Republic of the Congo DOI Creative Commons

Emmanuel Hasivirwe Vakaniaki,

Cris Kacita, Eddy Kinganda-Lusamaki

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 14, 2024

ABSTRACT Background Monkeypox virus (MPXV) attracted global attention in 2022 during a widespread outbreak linked primarily to sexual contact. Clade I MPXV is prevalent Central Africa and characterized by severe disease high mortality, while II confined West associated with milder illness. A IIb emerged Nigeria 2017, protracted human-to-human transmission forerunner of the B.1 lineage 2022. In October 2023, large mpox Kamituga mining region Democratic Republic Congo (DRC), which we conducted an investigation. Methods Surveillance data hospital records were collected between 2023 January 2024. Blood samples skin/oropharyngeal swabs obtained for molecular diagnosis at National Institute Biomedical Research, Kinshasa. genomes sequenced analyzed using Illumina NextSeq 2000 bioinformatic tools. Results The spread rapidly, 241 suspected cases reported within 5 months first case. Of 108 confirmed cases, 29% sex workers, highlighting contact as key mode infection. Genomic analysis revealed distinct Ib lineage, divergent from previously strains DRC. Predominance APOBEC3-type mutations estimated time emergence around mid-September suggest recent transmission. Conclusions Urgent measures, including reinforced, expanded surveillance, tracing, case management support, targeted vaccination are needed contain this new pandemic-potential outbreak.

Language: Английский

Citations

29
Suspected and confirmed mpox cases in DR Congo: a retrospective analysis of national epidemiological and laboratory surveillance data, 2010–23 DOI
Eugene Bangwen,

Ruth Diavita,

Elise De Vos

et al.

The Lancet, Journal Year: 2025, Volume and Issue: 405(10476), P. 408 - 419

Published: Jan. 30, 2025

Language: Английский

Citations

5
Modelling vaccination approaches for mpox containment and mitigation in the Democratic Republic of the Congo DOI Creative Commons
Alexandra Savinkina, Jason Kindrachuk, Isaac I. Bogoch

et al.

The Lancet Global Health, Journal Year: 2024, Volume and Issue: 12(12), P. e1936 - e1944

Published: Oct. 9, 2024

Language: Английский

Citations

10
A Comparative Evaluation of Three Diagnostic Assays for the Detection of Human Monkeypox DOI Creative Commons
Jing Qu, Xiaomin Zhang, K. Liu

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1286 - 1286

Published: Aug. 12, 2024

Accurate and early diagnosis of monkeypox virus (MPXV) is crucial for controlling epidemics treating affected individuals promptly. This study aimed to assess the analytical clinical performance MolecisionTM Monkeypox Virus qPCR Assay, Biorain ddPCR MAGLUMI® Ag (chemiluminescence immunoassay, CLIA) Assay. Additionally, it compare application antigen nucleic acid assays offer insights into using commercial assay kits. Specimens from 117 patients, serial diluted cell culture supernatant, artificially created positive samples were tested evaluate these kits MPXV diagnostics. The Assay had a limit detection (LoD) 3.89 CCID50/mL, while an LoD 15.55 CCID50/mL. (CLIA) 0.500 pg/mL. accuracy was comparable demonstrated high sensitivity. specificity all three diagnostic specimens with potential cross-reacting substances 100%. In conclusion, this provides valuable assays, supporting efforts mitigate control spread monkeypox.

Language: Английский

Citations

7
Strengthening Africa’s response to Mpox (monkeypox): insights from historical outbreaks and the present global spread DOI Creative Commons
David B. Olawade, Ojima Z. Wada,

Sandra Chinaza Fidelis

et al.

Science in One Health, Journal Year: 2024, Volume and Issue: 3, P. 100085 - 100085

Published: Jan. 1, 2024

Mpox, formerly known as Monkeypox, is a viral zoonotic disease endemic to Central and West Africa that has posed significant public health challenges since its identification in 1970. Despite decades of experience managing outbreaks, the 2022-2024 Mpox outbreaks exposed substantial gaps global preparedness response, leading World Health Organization (WHO) declare Public Emergency International Concern (PHEIC) 2022. The resurgence cases Europe 2022 more recent emergence virulent clade Ⅰb Democratic Republic Congo (DRC) 2024 have highlighted critical need for improved proactive response strategies curb epidemic. This narrative review examines historical epidemiology explores factors limited effective management. These include objective influences such mutations, transmission patterns, environmental changes like deforestation, well subjective factors, including delayed responses, vaccine availability, cessation smallpox vaccinations, inequitable access healthcare. In particular, emphasizes ongoing disparities equity, wealthier nations been able secure vaccines therapeutics quickly, while regions continue struggle with resources. also discusses how socio-economic cultural combined weak infrastructure inadequate surveillance systems, perpetuate cycles outbreak vulnerable populations. Furthermore, 2024, higher virulence mortality rates among children, particularly rural areas, underscores urgency addressing evolving epidemiological landscape Mpox. these challenges, this recommends strengthening healthcare infrastructure, enhancing ensuring equitable treatments, integrating management into strategies. Global collaboration remains essential provide African countries resources support needed manage prevent future effectively. Without measures, world risks prolonged crisis far-reaching consequences both community.

Language: Английский

Citations

6
Epidemiologic Quantities for Monkeypox Virus Clade I from Historical Data with Implications for Current Outbreaks, Democratic Republic of the Congo DOI Creative Commons
Valentina Marziano, Giorgio Guzzetta, Ira M. Longini

et al.

Emerging infectious diseases, Journal Year: 2024, Volume and Issue: 30(10)

Published: Sept. 25, 2024

We used published data from outbreak investigations of monkeypox virus clade I in the Democratic Republic Congo to estimate distributions critical epidemiological parameters. estimated a mean incubation period 9.9 days (95% credible interval [CrI] 8.5-11.5 days) and generation time 17.2 CrI 14.1-20.9 or 11.3 9.4-14.0 days), depending on considered dataset. Presymptomatic transmission was limited. Those estimates suggest generally slower dynamics than IIb. The time-varying reproduction number for be below epidemic threshold first half 2024. However, South Kivu Province, where newly identified subclade Ib has been associated with sustained human-to-human transmission, we an effective above 0.96-1.27).

Language: Английский

Citations

5
Mpox in the Democratic Republic of Congo: Analysis of National Epidemiological and Laboratory Surveillance Data, 2010 - 2023 DOI
Eugene Bangwen,

Ruth Diavita,

Elise De Vos

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

4
Roles of community and sexual contacts as drivers of clade I mpox outbreaks DOI Creative Commons
Hiroaki Murayama, Toshiaki Asakura, Borame Sue Lee Dickens

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Initial investigation into the emerging mpox outbreak of novel clade Ib in eastern Democratic Republic Congo has identified signs sustained human-to-human transmission and epidemiological links to sexual contacts involving female sex workers (FSWs), which have not been observed previous Ia outbreaks. Using mathematical models incorporating age-dependent contact patterns, we quantified role frequent interactions as opposed community dynamics found that this additional mode could explain its increased potential compared with Ia. As globally-circulating IIb transmitted predominantly among men who men, our findings reinforce importance protecting key population groups, specifically FSWs for Ib, controlling ongoing

Language: Английский

Citations

4