Protective Effects of Recombined Mussel Adhesive Protein against AD Skin Inflammation in Mice DOI Creative Commons
Yu Wu, Feng Li,

Yan Gong

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(4), P. 134 - 134

Published: Aug. 9, 2024

(1) Background: Atopic dermatitis (AD) is characterized as a chronic inflammatory skin disease with significant incidence rate. The pathophysiological mechanisms underlying AD remain incompletely understood. However, extensive research demonstrates that complex interplay among genetic, immune, and environmental factors contributes to the disruption of barrier function. Inflammation identified one pathological in AD. Recombined mussel adhesive protein exhibits anti-inflammatory properties. recombinant has been used less frequently for AD, so we explored therapeutic effect potential mechanism. (2) Methods: We established mice model vivo an LPS-induced inflammation HaCaT cells vitro. Through assessment lesion scores, itch frequency, transepidermal water loss, microcirculation, HE staining, Elisa assays IL-6, IL-12, IL-13, IL-4, IL-5, IFN-γ, IgE, TNF-α, immunohistochemical staining filaggrin CK14, Masson Western blot analysis NF-κB p65, P-P65, Keap1, Nrf2, effects recombined on symptoms, pathology, inflammation, its are investigated. (3) Results: significantly improved compromised barrier, reduced scratching frequency mice, decreased lowered expression factors, thus ameliorating damage. Mechanistically, downregulated P-p65/p65 Keap1 while upregulating level Nrf2. (4) Conclusions: Overall, our results demonstrate effectiveness attenuating DNFB-induced by inhibiting activating Keap1/Nrf2 signaling pathway. Thus, promising candidate treatment

Language: Английский

Transdermal Drug Delivery: An Overview of the Evolving Field DOI Creative Commons
Gözde Aktürk, Özgür Gündüz

Balkan Medical Journal, Journal Year: 2025, Volume and Issue: 42(1), P. 3 - 4

Published: Jan. 3, 2025

Language: Английский

Citations

0
A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of Viola yedoensis Makino DOI Creative Commons
Shuang Wang, Congcong Shen,

Shengyu Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1922 - 1922

Published: April 25, 2025

Viola yedoensis Makino (V. yedoensis), a perennial herb in the Violaceae family, is recognized for its violet flowers and has longstanding role ethnomedicine treating various inflammatory diseases, such as boils, furuncles, carbuncles, both acute chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including Chinese Pharmacopoeia, Flora of China, Web Science, PubMed, Baidu Scholar, Google China National Knowledge Infrastructure (CNKI). This paper serves inaugural latest findings regarding botany, traditional applications, phytochemistry, pharmacological properties, quality control, prospective uses V. yedoensis. The objective to provide robust foundation future research suggest novel avenues exploring potential applications. To date, 162 chemical constituents have been isolated from yedoensis, with flavonoids coumarins identified particularly abundant. These compounds exhibit promising activities, anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver anti-bacterial, anti-coagulant, anti-complement, anti-oxidant properties. Despite considerable advancements fundamental on further investigations are required elucidate underlying mechanisms action discover additional uncharacterized compounds. underscores plant’s significant development potential, highlighting necessity more in-depth exploration.

Language: Английский

Citations

0
A review of comorbidities in atopic dermatitis DOI

Ozlem Apti Sengkioun,

Andaç Salman

Indian Journal of Skin Allergy, Journal Year: 2024, Volume and Issue: 3, P. 87 - 92

Published: Aug. 12, 2024

Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder that can affect people of all ages. Considering its high disease burden, it traditionally linked with psychosocial comorbidities, including depression, anxiety, social and substantially impaired quality life. With advancements in understanding the pathogenesis AD critical importance comorbidities managing patients conditions, an increased number studies have recently shown variety are more frequently seen AD. The recognition these important for optimum management selection systemic treatments. In this review, pediatric adult summarized.

Language: Английский

Citations

1
Protective Effects of Recombined Mussel Adhesive Protein against AD Skin Inflammation in Mice DOI Creative Commons
Yu Wu, Feng Li,

Yan Gong

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(4), P. 134 - 134

Published: Aug. 9, 2024

(1) Background: Atopic dermatitis (AD) is characterized as a chronic inflammatory skin disease with significant incidence rate. The pathophysiological mechanisms underlying AD remain incompletely understood. However, extensive research demonstrates that complex interplay among genetic, immune, and environmental factors contributes to the disruption of barrier function. Inflammation identified one pathological in AD. Recombined mussel adhesive protein exhibits anti-inflammatory properties. recombinant has been used less frequently for AD, so we explored therapeutic effect potential mechanism. (2) Methods: We established mice model vivo an LPS-induced inflammation HaCaT cells vitro. Through assessment lesion scores, itch frequency, transepidermal water loss, microcirculation, HE staining, Elisa assays IL-6, IL-12, IL-13, IL-4, IL-5, IFN-γ, IgE, TNF-α, immunohistochemical staining filaggrin CK14, Masson Western blot analysis NF-κB p65, P-P65, Keap1, Nrf2, effects recombined on symptoms, pathology, inflammation, its are investigated. (3) Results: significantly improved compromised barrier, reduced scratching frequency mice, decreased lowered expression factors, thus ameliorating damage. Mechanistically, downregulated P-p65/p65 Keap1 while upregulating level Nrf2. (4) Conclusions: Overall, our results demonstrate effectiveness attenuating DNFB-induced by inhibiting activating Keap1/Nrf2 signaling pathway. Thus, promising candidate treatment

Language: Английский

Citations

0