Advanced 3D Materials for Corneal Stroma Regeneration: A Preclinical Progress

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, signaling cues in corneal stroma engineering to advance next-generation vision therapies.

Language: Английский

Risk of Permanent Corneal Injury in Microgravity: Spaceflight-Associated Hazards, Challenges to Vision Restoration, and Role of Biotechnology in Long-Term Planetary Missions

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 602 - 602

Published: April 4, 2025

Human space exploration presents an unparalleled opportunity to study life in extreme environments—but it also exposes astronauts physiological stressors that jeopardize key systems like vision. Corneal health, essential for maintaining precise visual acuity, is threatened by microgravity-induced fluid shifts, cosmic radiation, and the confined nature of spacecraft living environments. These conditions elevate risk corneal abrasions, infections, structural damage. In addition, Spaceflight-Associated Neuro-Ocular Syndrome (SANS)—while primarily affecting posterior segment—has been potentially linked anterior segment alterations such as edema tear film instability. This review examines these ocular challenges assesses current mitigation strategies. Traditional approaches, terrestrial eye banking transplantation, are impractical spaceflight due limited viability preserved tissues, surgical complexities, anesthetic risks, infection potential, logistical constraints. The paper explores emerging technologies 3D bioprinting stem cell-based tissue engineering, which offer promising solutions enabling on-demand production personalized constructs. Complementary advancements, including adaptive protective eyewear, bioengineered substitutes, telemedicine, AI-driven diagnostic tools, show potential autonomously managing health during long-duration missions. By addressing complex interplay environmental biological vulnerabilities, innovations not only safeguard astronaut vision mission performance but catalyze new pathways regenerative medicine on Earth. evolution space-based ophthalmic care underscores dual impact investments across planetary systems.

Language: Английский

Evaluation methods for decellularized tissues: A focus on human amniotic membrane

Journal of Bioscience and Bioengineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский