Green chemistry approach for rapid synthesis of indol-3-yl-4H-pyran derivatives, biological assessments, and toxicological activities against Cowpea aphid (Aphis craccivora)

Bulletin of the Chemical Society of Ethiopia, Journal Year: 2024, Volume and Issue: 38(4), P. 1077 - 1090

Published: April 30, 2024

From diverse or indole-3-carbaldehyde, certain unique indol-3-yl-4H-pyran derivatives were generated by condensing with different nucleophiles. IR, 1HNMR, and elemental studies have all confirmed their chemical structures. The green catalyst for the formation of is a zinc-linked amino acid complex [Zn(L-proline)2]. Furthermore, environmental friendliness this synthetic technique was investigated assessing reusability Zn(L-proline)2 over five consecutive cycles no significant loss catalytic activity. This novel process has showed substantial advantages in terms safety, simplicity, stability, mild conditions, short reaction time, excellent yields, good purity without use organic solvents. antibacterial properties compounds produced discovered to be promising. To determine whether are appropriate as possible insecticidal agents, toxicological activity synthesized against Cowpea aphid, Aphis craccivora, tested using leaf dip bioassay toxicity performed laboratory. KEY WORDS: One pot synthesis, Zn(L-proline)2, Indole-3-carbaldehyde, Aqueous media, Microwave irradiation, Bull. Chem. Soc. Ethiop. 2024, 38(4), 1077-1090. DOI: https://dx.doi.org/10.4314/bcse.v38i4.21

Language: Английский

Nickel oxide nanoparticles as sustainable catalysts for efficient synthesis and anti-microbial evaluation of 2-amino-4H-pyran derivatives

Bulletin of the Chemical Society of Ethiopia, Journal Year: 2024, Volume and Issue: 38(3), P. 657 - 670

Published: March 12, 2024

In the current paper, nickel oxide nanoparticles (NiO NPs) was successfully applied as a sustainable effective and recoverable catalyst for preparation of 2-amino-4H pyran derivatives 2-11 via one-pot, three-component reaction 4-formylphenyl-4-methyl benzenesulfonate (1) with malononitrile active methylene compounds in green solvent water ethanol ratio (3:1) excellent yield (95-98%) shorter time (5-8 min). The structures were elucidated by elemental spectral analyses such IR, 1H NMR, 13C NMR DEPT 135 spectra. Moreover, characterization after before studied using X-ray diffraction (X-RD), scanning electron microscope (SEM), EDX techniques IR-spectra. It has been indicated that same efficiency. application this protocol many advantages eco-friendly, inexpensive, simple easy recovery catalyst. Overall products are designed, synthesized their anti-microbial evaluation. found is 2, 3, 7 10 most against antibacterial compression stander drug Ampicillin. On other hand, Compounds 8, 11 displayed promising antifungal activities Amphotericin B. KEY WORDS: Nickel nanoparticles, Pyran derivatives, X-Ray Antimicrobial evaluation, One-pot, Three-component reaction Bull. Chem. Soc. Ethiop. 2024, 38(3), 657-670. DOI: https://dx.doi.org/10.4314/bcse.v38i3.9

Language: Английский

Nickel Nanoparticles as a Sustainable Catalyst for the Synthesis of 2H‐Pyran Derivatives under Microwave Irradiation, and their Anti‐Inflammatory Activity

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract This study includes an environmentally and effectively green method for the synthesis of novel 2 H ‐pyran derivatives 4 a–h via a one‐pot reaction different aromatic aldehydes 1 with ethyl cyanoacetate ( ) 2‐acetylphenyl‐4‐tolylsulfonate 3 in presence nickel oxide nanoparticles (NiO NPs) as catalyst aqueous mixed solution (EtOH: O, : ratio) using microwave irradiation. The structure all prouducts were confirmed by spectral data elemental analysis. All compounds investigated anti‐inflammatory activity compared celecoxib reference drug. obtained results indicate that 2‐[4‐(4‐tosyl oxy phenyl)‐3‐cyano‐2‐oxo‐2 ‐pyran‐6‐yl]phenyl 4‐tolylsulfonate b is most effective, which showed after 5 h., significantly inhibited inflammation carrageenan alone group (P < 0.0001)., when to treated celecoxib, was 42.38 % compound 48.39 simultaneously. Moreover, its histopathological examination studied significant attenuation edema. indicated pyran could serve promising lead further optimization agents. present protocol offers several advantages, such inexpensive, easy work, pure products, shorter times, excellent yields, environmental friendliness, reuse times.

Language: Английский