COVID-19 outbreaks caused by different SARS-CoV-2 variants: a descriptive, comparative study from China DOI Creative Commons
Cao Chen,

Yenan Feng,

Zeyuan Yin

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 12, 2024

Objectives To understand the epidemic characteristics of various SARS-CoV-2 variants, we mainly focus on analyzing general profiles, viral mutation, and evolution COVID-19 outbreaks caused by different variants concern (VOCs) in China as August 2022. Methods We systematically sorted out profiles VOCs China, compared differences Delta Omicron VOCs, analyzed mutational changes subvariants between same outbreak outbreaks. Findings By 15 2022, a total 2, 33, 124 Alpha, Delta, respectively, were reported regions China. In terms number outbreaks, extent affected areas, confirmed cases, more widespread than other variants. The most frequently circulating PANGO lineages B.1.617.2 AY.122 BA.2.2.1, BA.2, BA.2.2, BA.5 for VOCs. Additional mutations genome strain observed with longer duration higher numbers infections. Conclusion Through comprehensive analysis influences, found continued to evolve within across occurring locations or at times. These findings suggest that rapidly containing an virus can not only reduce spread but also delay virus’s mutation frequency.

Language: Английский

Genomic Surveillance for SARS-CoV-2 — China, September 26, 2022 to January 29, 2023 DOI Open Access

Shiwen Wang,

Peihua Niu,

Qiudong Su

et al.

China CDC Weekly, Journal Year: 2023, Volume and Issue: 5(7), P. 143 - 151

Published: Jan. 1, 2023

Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has generated 2,431 variants over the course of its global transmission past 3 years. To better evaluate genomic variation SARS-CoV-2 before and after optimization disease 2019 (COVID-19) prevention control strategies, we analyzed genetic evolution branch composition in both domestic imported cases China (the data from Hong Kong Macau Special Administrativc Regions Taiwan, were not included) September 26, 2022 to January 29, 2023. Methods Analysis number genome sequences, sampling time, dynamic changes evolutionary branches, origin, clinical typing submitted by 31 provincial-level administrative divisions (PLADs) Xinjiang Production Construction Corp (XPCC) was conducted assess accuracy timeliness variant surveillance. Results From 2023, 20,013 valid sequences reported China, with 72 branches. Additionally, 1,978 reported, 169 prevalence Omicron consistent that international epidemic variants. Conclusions This study provides an overview China. After optimizing COVID-19 no novel altered biological characteristics or public health significance have been identified since December 1, 2022.

Language: Английский

Citations

27
The relative prevalence of the Omicron variant within SARS-CoV-2 infected cohorts in different countries: A systematic review DOI Creative Commons
Aparajita Sarkar,

Sara Omar,

Aya Alshareef

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(1)

Published: Jan. 2, 2023

The Omicron variant of SARS-CoV-2 was detected in October 2021 and exhibited high transmissibility, immune evasion, reduced severity when compared to the earlier variants. lesser vaccine effectiveness against its created vaccination hesitancy among public. This review compiled data reporting relative prevalence as early variants give an insight into existing variants, which may shape decisions regarding targets newly developed vaccines. Complied revealed more than 90% within infected cohorts some countries. BA.1 subvariant predominated over BA.2 during stages wave. Moreover, BA.4/BA.5 subvariants were South Africa, USA Italy between April 2022. It is therefore important develop vaccines that protect well are known cause severe complications.

Language: Английский

Citations

27
SARS-CoV-2 Surveillance Through China Influenza Surveillance Information System — China, December 1, 2022 to February 12, 2023 DOI Open Access

Xiaoxu Zeng,

Yiran Xie,

Xiaokun Yang

et al.

China CDC Weekly, Journal Year: 2023, Volume and Issue: 5(7), P. 152 - 158

Published: Jan. 1, 2023

The World Health Organization (WHO) proposed using influenza surveillance systems to carry out coronavirus disease 2019 (COVID-19) due the similarity between two diseases in some respiratory symptoms. To assess prevalence of COVID-19, we analyzed influenza-like illness (ILI) and positive rate severe acute syndrome 2 (SARS-CoV-2) detections ILI patients reported Surveillance Information System (CNISIS) since late 2022.Data related were by national sentinel hospitals. Positive testing for SARS-CoV-2 viruses was conducted real-time reverse transcription polymerase chain reaction (rRT-PCR) detection network laboratories. data CNISIS.Beginning on December 12, 2022 (Week 50), percentage increased dramatically, peaking Week 51 at 12.1%. Subsequently, began decline rapidly from 52, 2022, 6, 2023 (February 6-12), had returned levels observed beginning 2022. From 1, February 2023, 115,844 specimens tested both virus. Of these, 30,381 (26.2%) 1,763 (1.5%) tests peaked 74.1% around 23 25.Sentinel-based surveillance, previously established influenza, is an effective way track circulation trend during community-level epidemics. There no co-prevalence virus outbreak SARS-CoV-2, even winter season. However, it important remain vigilant potential rise activities following COVID-19 epidemic.

Language: Английский

Citations

11
Surveillance and Analysis of SARS-CoV-2 Variant Importation — China, January–June 2022 DOI Open Access

Yenan Feng,

Xiang Zhao, Zeyuan Yin

et al.

China CDC Weekly, Journal Year: 2022, Volume and Issue: 4(50), P. 1136 - 1142

Published: Jan. 1, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is the dominant circulating strain worldwide. To assess importation of SARS-CoV-2 variants in mainland China during epidemic, genomic surveillance data from imported disease 2019 (COVID-19) cases first half 2022 were analyzed.Sequences submitted January to July 2022, with a collection date before June 30, incorporated. proportions as well relationships between origin and destination each case analyzed.4,946 sequences 27 provincial-level administrative divisions (PLADs), median submission interval was within 1 month after collection. In 3,851 good quality, recombinant (XU) 4 subvariants under monitoring (BA.4, BA.5, BA.2.12.1, BA.2.13) recorded, 3 them BA.2.12.1) caused local transmissions later than that recorded surveillance. dominated shifted BA.1 BA.2 then BA.4 BA.5. percentage far higher Global Initiative on Sharing All Influenza Data (GISAID). Hong Kong Special Administrative Region, China, accounted for 32.30% sampled, 98.71% BA.2.The showed intra-Omicron evolution all introduced into multiple times different locations.

Language: Английский

Citations

8
Systematic Genomic Surveillance of SARS-CoV-2 at Xiamen International Airport and the Port of Xiamen Reveals the Importance of Incoming Travelers in Lineage Diversity DOI Creative Commons

Ruiluan You,

Ruotong Wu,

Xijing Wang

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(1), P. 132 - 132

Published: Jan. 17, 2024

Sever Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is still a threat to human health globally despite the World Health Organization (WHO) announcing end of COVID-19 pandemic. Continued surveillance SARS-CoV-2 at national borders would be helpful in understanding epidemics novel imported variants and updating local strategies for disease prevention treatment. This study focuses on among travelers entering Xiamen International Airport Port from February August 2023. A total 97 sequences 223 cases collected 12 different countries regions were identified by real-time RT-PCR. Next-generation sequencing was used generate high-quality complete phylogenetic population dynamic analysis. The revealed dominant shift variant distribution, which XBB subvariant (XBB.1.5, XBB.1.16, XBB.1.9, XBB.2.3, EG.5.1) accounted approximately 88.8% sequenced samples. In detail, clades 23D 23E 26.2% 21.4% samples, respectively, while 23B (13.6%) 23F (10.7%) took third fourth spots order sequences, respectively. Additionally, XBB.2.3 first mainland Xiamen, China 27 spatiotemporal analyses recent viral genome limited number into provide valuable insights situation surrounding highlight importance sentinel border screening incoming travelers, serves as an early warning system presence highly transmissible circulating lineages.

Language: Английский

Citations

1
Prevalence and diversity of imported severe acute respiratory syndrome coronavirus 2 variants in China, 2021–2022 DOI

Yenan Feng,

Xiang Zhao, Zhixiao Chen

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(5)

Published: May 1, 2024

The causative agent of coronavirus disease 2019 (COVID-19), known as severe acute respiratory syndrome 2 (SARS-CoV-2), has spread accumulatively to 240 countries and continues evolve. To gain a comprehensive understanding the epidemiological characteristics imported variants in China their correlation with global circulating variants, genomic surveillance data from 11 139 COVID-19 cases submitted by Chinese provincial CDC laboratories between 2021 2022 were analyzed. Consensus sequences underwent rigorous quality checks, followed amino acid mutations analysis using Nextclade. Sequences satisfactory control status classified according Pango nomenclature. results showed that dominant reflected epidemic trend. An increase number SARS-CoV-2 lineages monitored second half 2022, Omicron subvariants changed ancestral BA.5 BA.2 into containing key spike protein. There was significant variation detection among continents (χ

Language: Английский

Citations

0
Associations between genetic mutations in different SARS-CoV-2 strains and negative conversion time of viral RNA among imported cases in Hangzhou: A cross-sectional study DOI Creative Commons
Yì Wáng, Hua Yu, Tao Zhang

et al.

Virus Research, Journal Year: 2024, Volume and Issue: 345, P. 199400 - 199400

Published: May 20, 2024

Previous studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused factors that influence the achievement of negative conversion viral RNA. This study aimed to investigate effects genetic mutations in different SARS-CoV-2 strains time (NCT) among imported cases Hangzhou, Zhejiang Province, China, order provide valuable insights for developing targeted epidemic prevention guidelines.

Language: Английский

Citations

0
COVID-19 outbreaks caused by different SARS-CoV-2 variants: a descriptive, comparative study from China DOI Creative Commons
Cao Chen,

Yenan Feng,

Zeyuan Yin

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 12, 2024

Objectives To understand the epidemic characteristics of various SARS-CoV-2 variants, we mainly focus on analyzing general profiles, viral mutation, and evolution COVID-19 outbreaks caused by different variants concern (VOCs) in China as August 2022. Methods We systematically sorted out profiles VOCs China, compared differences Delta Omicron VOCs, analyzed mutational changes subvariants between same outbreak outbreaks. Findings By 15 2022, a total 2, 33, 124 Alpha, Delta, respectively, were reported regions China. In terms number outbreaks, extent affected areas, confirmed cases, more widespread than other variants. The most frequently circulating PANGO lineages B.1.617.2 AY.122 BA.2.2.1, BA.2, BA.2.2, BA.5 for VOCs. Additional mutations genome strain observed with longer duration higher numbers infections. Conclusion Through comprehensive analysis influences, found continued to evolve within across occurring locations or at times. These findings suggest that rapidly containing an virus can not only reduce spread but also delay virus’s mutation frequency.

Language: Английский

Citations

0