Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite–Salicylic Acid–Silica Nanocomposite with Sustained-Release Capacity DOI Open Access

Doina-Antonia Mercan,

Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(23), P. 5816 - 5816

Published: Nov. 27, 2024

Iron oxide nanoparticles were synthesized using a vortex microfluidic system and subsequently functionalized with primary shell of salicylic acid, recognized for its ability to increase the stability biocompatibility coated materials. In second stage, platform was placed in magnetic field facilitate growth development porous silica shell. The selected drug this study micafungin, an antifungal agent well regarded effectiveness combating fungal infections identified as priority compound by World Health Organization (WHO). resulting nanocomposite characterized various techniques, including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET) analysis, UV-Vis spectroscopy, ion cyclotron resonance mass spectrometry (FT-ICR MS). synthesis method produced dimensions 5–7 nm, highlighting advantages chosen approach. A desorption profile established continuous-flow, analysis system, indicating that bioactive released slowly; after two hours, approximately 50% loaded micafungin detected release medium. Furthermore, results obtained from FT-ICR MS provided molecular-level confirmation, thereby supporting mechanism nanosystem.

Language: Английский

Agricultural Residues to High-Value Nanomaterials: Pathways to Sustainability DOI Creative Commons
Kelvin Adrian Sanoja‐López,

Jeffrey Saúl Cedeño-Muñoz,

Bryan Fernando Rivadeneira-Mendoza

et al.

Resources Conservation & Recycling Advances, Journal Year: 2025, Volume and Issue: unknown, P. 200243 - 200243

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoscale Effects in the Room-Temperature UV–Visible Photoluminescence from Silica Particles and Its Cancer Cell Imaging DOI

Divya Rani,

Deepika Singh, Anil Kumar

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Silica nano/microparticles have generated significant interest for the past decades, emerging as a versatile material with wide range of applications in photonic crystals, bioimaging, chemical sensors, and catalysis. This study focused on synthesizing silica ranging from 20 nm to 1.2 μm using Stöber modified methods. The particles exhibited photoluminescence emission across UV-visible range, specifically UV (∼290, ∼327, ∼339, ∼377 nm), blue (∼450 green (∼500 yellow (∼576 red (∼634 nm) electromagnetic spectrum. These emissions are due radiative relaxation processes involving oxygen-deficient centers arising unrelaxed oxygen vacancies, strong interacting surface silanols, 2-fold coordinated silicon, self-trapped excitons, hydrogen-related species, strain-induced defects, nonbridging hole excited via two-photon single photon absorption. increased PL intensity decreasing particle size was attributed higher concentrations defect sites case smaller-sized particles. MTT assay, AO/EB staining, DCFDA assay confirmed biocompatible nature HepG2 cell line. In addition, viability normal line (HEK293) also showed no substantial death. Successful bioimaging cells performed nano/microparticles, which fluorescence, along Hoechst33258 dye. Even though nm-sized emission, sized above better fluorescence cells, citing their potential vitro applications.

Language: Английский

Citations

0
Efficacy of different forms of concentrated growth factors combined with deproteinized bovine bone minerals in guided bone regeneration: a randomized clinical trial DOI Creative Commons
Lei Zhu, Xiaoqing Du, Gang Fu

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

Language: Английский

Citations

0
Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite–Salicylic Acid–Silica Nanocomposite with Sustained-Release Capacity DOI Open Access

Doina-Antonia Mercan,

Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(23), P. 5816 - 5816

Published: Nov. 27, 2024

Iron oxide nanoparticles were synthesized using a vortex microfluidic system and subsequently functionalized with primary shell of salicylic acid, recognized for its ability to increase the stability biocompatibility coated materials. In second stage, platform was placed in magnetic field facilitate growth development porous silica shell. The selected drug this study micafungin, an antifungal agent well regarded effectiveness combating fungal infections identified as priority compound by World Health Organization (WHO). resulting nanocomposite characterized various techniques, including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET) analysis, UV-Vis spectroscopy, ion cyclotron resonance mass spectrometry (FT-ICR MS). synthesis method produced dimensions 5–7 nm, highlighting advantages chosen approach. A desorption profile established continuous-flow, analysis system, indicating that bioactive released slowly; after two hours, approximately 50% loaded micafungin detected release medium. Furthermore, results obtained from FT-ICR MS provided molecular-level confirmation, thereby supporting mechanism nanosystem.

Language: Английский

Citations

1