Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver DOI Creative Commons
Dean G. Tang

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(8)

Published: April 14, 2025

Castration-resistant prostate cancer frequently metastasizes to the liver, and liver metastases often present a neuroendocrine phenotype (i.e., [NEPC]), but underlying molecular underpinnings remain unclear. In this issue of JCI, Liu et al. demonstrate that neurotransmitter serotonin (also known as 5-hydroxytryptamine), produced by NEPC cells, gained access activated neutrophils modifying histone 3 (H3) form neutrophil extracellular traps, which in turn promoted macrometastases liver. The study suggests blocking transport inhibiting enzymes catalyze serotonin-mediated H3 modifications may represent alternative approaches treating metastases.

Language: Английский

Energy Metabolism and Stemness and the Role of Lauric Acid in Reversing 5-Fluorouracil Resistance in Colorectal Cancer Cells DOI Open Access

Rina Fujiwara‐Tani,

Yi Luo,

Ruiko Ogata

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 664 - 664

Published: Jan. 14, 2025

While 5-fluorouracil (5FU) plays a central role in chemotherapy for colorectal cancer (CRC), resistance to 5FU remains major challenge CRC treatment, and its underlying mechanisms remain unclear. In this study, we investigated the relationship between acquisition, stemness, energy metabolism. Among two cell lines, HT29 cells exhibited glycolytic quiescent properties, while CT26 relied on oxidative phosphorylation (OXPHOS) energy. contrast, 5FU-resistant sublines (HT29R CT26R), developed through continuous exposure low concentrations of 5FU, demonstrated enhanced stemness. This was associated with dominance, proliferation, reduced reactive oxygen species (ROS) production. However, treatment medium-chain fatty acid lauric shifted OXPHOS, reducing increasing ROS levels, inducing death, therefore reversing resistance. These findings suggest that an enhancement stemness reprogramming metabolism play key roles acquiring CRC. reversed resistance, further clinical studies are required.

Language: Английский

Citations

1
Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver DOI Creative Commons
Dean G. Tang

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(8)

Published: April 14, 2025

Castration-resistant prostate cancer frequently metastasizes to the liver, and liver metastases often present a neuroendocrine phenotype (i.e., [NEPC]), but underlying molecular underpinnings remain unclear. In this issue of JCI, Liu et al. demonstrate that neurotransmitter serotonin (also known as 5-hydroxytryptamine), produced by NEPC cells, gained access activated neutrophils modifying histone 3 (H3) form neutrophil extracellular traps, which in turn promoted macrometastases liver. The study suggests blocking transport inhibiting enzymes catalyze serotonin-mediated H3 modifications may represent alternative approaches treating metastases.

Language: Английский

Citations

0