Weight loss with different types of fasting in patients with type two diabetes and hypertension: a randomized clinical trial DOI Creative Commons
Kuat Oshakbayev,

Alisher Idrissov,

Altay Nabiyev

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

ABSTRACT Background The coexistence of type two diabetes (T2D) and cardiovascular diseases (CVD) in patients with overweight increases the risk macro-vascular complications. Some studies are controversial results Ramadan fasting (RF) T2D+CVD. Objective To compare different RF (antique modern) on anthropometric, glycemic, blood pressure (BP), lipids, heel bone mineral density (HBMD), ejection fraction (EF) Methods An open, 60-day, controlled, single-center, randomized clinical trial included 51 (29 women) T2D+CVD: 26 Main RF); 25 Controls (modern RF). Primary endpoints: weight loss, glucose and, insulin, BP. Secondary HBMD, EF. Results Patients lost –8.02 kg ( P <0.0001), –2.67 <0.025); BMI significantly decreased but did not decrease P> 0.025). During a 30-day follow-up, regain WC; regained WC. In BP, all glycemic parameters (fasting glucose, immunoassay HOMA-IR), lipids (cholesterol, triglyceride, HDL), EF without heart failure (HF) were normalized at <0.0001). BP improved they achieve normal >0.025). HBMD HF change At Main; worsened as regained. Conclusion Both methods allowed antique led to markedly loss significant positive mineralization, T2D+CVD; stop taking medications. duration depended maintenance achieved RF. Trial Registration ClinicalTrials.gov NCT06410352 (05/08/2024): https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000EG8K&selectaction=Edit&uid=U0006MBT&ts=139&cx=bhsvd1

Language: Английский

Weight loss with different types of fasting in patients with type two diabetes and hypertension: a randomized clinical trial DOI Creative Commons
Kuat Oshakbayev,

Alisher Idrissov,

Altay Nabiyev

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

ABSTRACT Background The coexistence of type two diabetes (T2D) and cardiovascular diseases (CVD) in patients with overweight increases the risk macro-vascular complications. Some studies are controversial results Ramadan fasting (RF) T2D+CVD. Objective To compare different RF (antique modern) on anthropometric, glycemic, blood pressure (BP), lipids, heel bone mineral density (HBMD), ejection fraction (EF) Methods An open, 60-day, controlled, single-center, randomized clinical trial included 51 (29 women) T2D+CVD: 26 Main RF); 25 Controls (modern RF). Primary endpoints: weight loss, glucose and, insulin, BP. Secondary HBMD, EF. Results Patients lost –8.02 kg ( P <0.0001), –2.67 <0.025); BMI significantly decreased but did not decrease P> 0.025). During a 30-day follow-up, regain WC; regained WC. In BP, all glycemic parameters (fasting glucose, immunoassay HOMA-IR), lipids (cholesterol, triglyceride, HDL), EF without heart failure (HF) were normalized at <0.0001). BP improved they achieve normal >0.025). HBMD HF change At Main; worsened as regained. Conclusion Both methods allowed antique led to markedly loss significant positive mineralization, T2D+CVD; stop taking medications. duration depended maintenance achieved RF. Trial Registration ClinicalTrials.gov NCT06410352 (05/08/2024): https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000EG8K&selectaction=Edit&uid=U0006MBT&ts=139&cx=bhsvd1

Language: Английский

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