Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 13, 2024
Regulatory
immune
cells
regulate
responses
through
various
mechanisms,
affecting
the
occurrence,
development,
and
therapeutic
effects
of
tumors.
In
this
article,
we
reviewed
important
roles
regulatory
cells,
such
as
T
(Tregs),
B
(Bregs),
myeloid-derived
suppressor
(MDSCs),
dendritic
(DCregs),
tumor-associated
macrophages
(TAMs),
in
tumor
microenvironment
(TME).
The
immunomodulatory
natural
products,
polysaccharides,
polyphenols,
glycosides,
alkaloids,
terpenoids,
quinones,
other
compounds,
which
affect
functions
molecular
signaling
pathways,
thereby
enhancing
potential
antitumor
response,
are
discussed.
These
findings
provide
new
ideas
possibilities
for
application
products
treatment,
can
help
enhance
effectiveness
treatment
improve
patient
prognosis.
Language: Английский
Special issue: frontiers in recent advances on cancer diagnosis and treatment
Upsala Journal of Medical Sciences,
Journal Year:
2024,
Volume and Issue:
129, P. e11919 - e11919
Published: Dec. 31, 2024
‘Of
all
the
processes
that
student
of
pathology
is
privileged
to
study,
none
as
intriguing,
fascinating,
and
perplexing
neoplasia.’
This
statement,
a
quote
from
William
Boyd’s
Textbook
Pathology
(1961),
remains
thought-provoking
today
when
it
was
first
written.
Over
decades
since
Boyd
penned
these
words,
our
understanding
molecular
mechanisms
underlying
tumorigenesis
development
novel
therapeutic
approaches
have
advanced
at
revolutionary
pace.
special
issue
UJMS
on
cancer
exemplifies
remarkable
progress
in
research,
reaffirming
perspective
enigmatic
nature
endures.
Language: Английский