Patterns of C1-Inhibitor Plasma Levels and Kinin–Kallikrein System Activation in Relation to COVID-19 Severity DOI Creative Commons
Silvia Berra, Debora Parolin, Chiara Suffritti

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1525 - 1525

Published: Nov. 21, 2024

Background: Although more than four years have passed since the pandemic began, SARS-CoV-2 continues to be of concern. Therefore, research into underlying mechanisms that contribute development disease, especially in severe forms, remains a priority. Sustained activation complement (CS), contact (CAS), and fibrinolytic kinin–kallikrein systems (KKS) has been shown play central role pathogenesis disease. Since C1 esterase inhibitor (C1-INH) is potent all these systems, its disease investigated, but some issues remained unresolved. Methods: We evaluated impact C1-INH KKS on progression cohort 45 COVID-19 patients divided groups according severity. measured plasma levels total functional complexes with kallikrein (PKa), reflecting spontaneous activity. Results: observed increased concentrations patients. A direct correlation (positive Spearman’s r) was between levels, C1-INH, severity Moreover, significant reduction ratio over evident exhibiting mild intermediate clinical not critically ill Accordingly, KKS, assessed as an increase PKa:C1-INH complexes, explicitly categories. Conclusions: Our study’s findings consumption less stages critical stage suggest potential for containing These results underscore importance early phases implications and/or long-term effects.

Language: Английский

COVID-19 related complications DOI
Muhamed Adilović

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficacy of combined folic acid, cyanocobalamin, and pyridoxine hydrochloride therapy in the comprehensive management of pneumonia associated with COVID-19 DOI Creative Commons
I.Ya. Tseimakh, D.E. Bogachev,

A. Yu. Zhbanov

et al.

Bulletin physiology and pathology of respiration, Journal Year: 2025, Volume and Issue: 95, P. 40 - 57

Published: March 19, 2025

Aim. To evaluate the clinical efficacy and effect on serum homocysteine levels of combined folic acid, cyanocobalamin, pyridoxine hydrochloride therapy in comprehensive treatment pneumonia hospitalized patients with COVID-19. Materials methods. An open-label, prospective, comparative study included 75 moderate to severe associated COVID-19 confirmed by detection SARS-CoV-2 RNA respiratory tract. The main group consisted 28 who received micronutrient 30 mg/day acid plus cyanocobalamin addition standard treatment. comparison comprised 47 did not receive additional therapy. Charlson Comorbidity Index was 1.14 ± 0.93 0.47 0.69 (p ≤ 0.001). Disease severity before after assessed using NEWS, qSOFA, 4C Mortality, WHO Ordinal scales. Chest computed tomography (CT) performed. Laboratory parameters complete blood count, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), homocysteine, triglycerides, low- high-density lipoprotein cholesterol (LDL, HDL). Results. In group, elimination period achieved 7.2 3.4 days versus 15.6 6.3 < After therapy, disease decreased according qSOFA Mortality showed a reduction total volume from 32.0 (19.8–73.0)% 26.5 (11.8–50.8)% = 0.035) parenchymal consolidation 9.0 (0.0–37.3)% 2.0 (0.0–17.0)% 0.027). there no decrease lung involvement, area increased. These CT findings were reductions CRP, LDL levels. Multiple linear regression models demonstrated that administration combination shortened tract (regression coefficient β –8.648 1.781; p 0.001) contributed (β –13.492 4.834; 0.011), also linked baseline LDH 0.0235 0.00857; 0.008) patient age 0.167 0.0608; 0.008). Conclusion. use management COVID-19-associated is shorter upper tract, more pronounced severity, extent consolidation. effects coincide lower

Language: Английский

Citations

0
Complicated course of portal hypertension on the background of primary myelofibrosis: a clinical case DOI Creative Commons
V.B. Yagmur, N.Yu. Zavhorodnia, С.Л. Меланіч

et al.

GASTROENTEROLOGY, Journal Year: 2025, Volume and Issue: 59(1), P. 50 - 55

Published: March 25, 2025

Esophageal varices are a consequence of portosystemic collaterals that develop under conditions increased pressure between the portal and inferior vena cava. Bleeding from significantly worsens patient’s condition poses risk to his life. Portal hypertension is usually considered as complication liver cirrhosis, but there small pool patients with so-called extrahepatic causes. The second most frequent cause after cirrhosis vein thrombosis. article describes case clinically significant complicated by esophageal varices, which developed due thrombosis SARS-CoV-2 infection. During additional examination, was ruled out, further clinical search aimed at identifying other factors thrombophilia. As result morphological genetic diagnosis primary myelofibrosis made. Thus, in thrombosis, development hypertension, possibility myeloproliferative neoplasm should be exclusion cirrhosis.

Language: Английский

Citations

0
Superficial Vein Thrombosis in an Asymptomatic Case of Cholangiocarcinoma with Recent History of COVID-19 DOI Creative Commons
Mihai-Lucian Ciobica,

Bianca-Andreea Sandulescu,

M Sotcan

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1095 - 1095

Published: Aug. 30, 2024

The COVID-19 pandemic brought into prominence several emergent medical and surgical entities, but, also, it served as trigger contributor for numerous apparently unrelated ailments such arterial venous thromboembolic complications. Additional risk factors these thrombotic traits may be concurrent (known or unknown) malignancies, including at hepatic level. Among these, cholangiocarcinoma (CCA), a rare cancer of intra- extra-hepatic biliary ducts, represents very aggressive condition that typically associates local distant advanced stages on first presentation requiring prompt diagnosis stratified management. This neoplasia has been reported to present large spectrum paraneoplastic syndromes in terms dermatologic, renal, systemic, neurologic, endocrine, cardiovascular settings, that, overall, are exceptional their epidemiologic impact when compared other cancers. Our aim was introduce most unusual case CCA-associated thrombosis male adult who initially considered experience COVID-19-related features while having history obesity bariatric surgery. is hybrid type paper: this clinical vignette accompanied by two distinct sample-focused analyses basis discussion; they each had different methods depending current level statistical evidence. We only included English-published articles PubMed, follows: Firstly, we conducted search reports similar the case, regarding vein CCA, from inception until time. performed literature using keywords “cholangiocarcinoma”, “thrombosis”, “Trousseau’s syndrome” identified 20 cases across 19 original papers; hence, evidence remains low Secondly, searched highest concerning thrombosis/thromboembolism patients underwent infection (key were “COVID-19”, alternatively, “coronavirus”, “SARS-CoV-2”, “thromboembolism”) recent systematic reviews meta-analyses published 2024 (from 1 January 8 July 2024). After excluding data vaccination against coronavirus long syndrome, six articles. To conclude, presented probably unique malignancy with an initial manifestation consisting recurrent superficial under anticoagulation therapy, no gastrointestinal manifestations, patient notable multiple episodes SARS-CoV-2 prior endocrine (gastric) our knowledge, identification CCA specific circumstances.

Language: Английский

Citations

1
Obituary Professor Margareta “Meta” Blombäck (1925-2024) DOI Open Access

Jovan Antović,

Maria S Magnusson,

Hans Johnsson

et al.

Journal of Thrombosis and Haemostasis, Journal Year: 2024, Volume and Issue: 22(8), P. 2375 - 2377

Published: May 16, 2024

Citations

0
Patterns of C1-Inhibitor Plasma Levels and Kinin–Kallikrein System Activation in Relation to COVID-19 Severity DOI Creative Commons
Silvia Berra, Debora Parolin, Chiara Suffritti

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1525 - 1525

Published: Nov. 21, 2024

Background: Although more than four years have passed since the pandemic began, SARS-CoV-2 continues to be of concern. Therefore, research into underlying mechanisms that contribute development disease, especially in severe forms, remains a priority. Sustained activation complement (CS), contact (CAS), and fibrinolytic kinin–kallikrein systems (KKS) has been shown play central role pathogenesis disease. Since C1 esterase inhibitor (C1-INH) is potent all these systems, its disease investigated, but some issues remained unresolved. Methods: We evaluated impact C1-INH KKS on progression cohort 45 COVID-19 patients divided groups according severity. measured plasma levels total functional complexes with kallikrein (PKa), reflecting spontaneous activity. Results: observed increased concentrations patients. A direct correlation (positive Spearman’s r) was between levels, C1-INH, severity Moreover, significant reduction ratio over evident exhibiting mild intermediate clinical not critically ill Accordingly, KKS, assessed as an increase PKa:C1-INH complexes, explicitly categories. Conclusions: Our study’s findings consumption less stages critical stage suggest potential for containing These results underscore importance early phases implications and/or long-term effects.

Language: Английский

Citations

0