Variation in Columbin Content in Rhizome of different Tinospora sagittata Varieties DOI Creative Commons

Yonghui Sang,

Mohammad Murtaza Alami, Huaijun Si

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Columbin, a key secondary metabolite in Tinospora sagittata, exhibits diverse pharmacological properties, yet its content shows notable variation across different varieties. This study investigated the molecular and biochemical basis behind such variation, analyzing columbin 32 T. sagittata varieties ranging from 5.40 mg/g to 46.09 mg/g. High low-columbin-content were selected for in-depth transcriptomic untargeted metabolomic analyses. Differential expression patterns of genes metabolites between leaves rhizomes these explored. Results revealed that involved biosynthesis pathway, namely, DXS, DXR, MCS, GPPS, PMK, exhibited significantly higher high At same time, HMGR HDR levels notably lower. Furthermore, columbin-content contained increased isoprene levels, crucial precursor. These findings suggest gene precursor variations likely drive differences insight into clarifies provides valuable direction breeding cultivating varieties, amplifying potential therapeutic applications.

Language: Английский

Predicting the potential habitats of two Lycium species and the quality suitability of Lycium Chinese Mill. Cortex under climate change DOI
Yuting Liu,

Zhao‐Cen Lu,

Xiyou Fu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Lycii Cortex is a frequently utilized traditional Chinese medicine with notable therapeutic properties. The impact of climate change on its distribution and quality significant concern. In this study, it investigated the geographic two sources plants for collected data samples from different origins via an online survey. HPLC was employed to ascertain concentrations kukoamine B A in samples. Subsequently, integrated ecological factor were forecast prospective expansion areas Lycium Chinese Mill. barbarum L. under future climatic conditions, migration trajectory suitable habitat centers mass, potential factors at varying times using Maxent ArcGIS. current scenario indicates that habitats barbarum are primarily distributed northern, northwestern, southwestern regions China, while Chinese predominantly central, southern, southeastern China. RCP4.5 2050s 2070s, total area deemed both species significantly reduced. mean center shifted towards higher latitudes, lower latitudes. It predicted future, would appear decrease. results study can provide reference determination cultivation China sustainable development Lycium resources.

Language: Английский

Citations

0
Variation in Columbin Content in Rhizome of different Tinospora sagittata Varieties DOI Creative Commons

Yonghui Sang,

Mohammad Murtaza Alami, Huaijun Si

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Columbin, a key secondary metabolite in Tinospora sagittata, exhibits diverse pharmacological properties, yet its content shows notable variation across different varieties. This study investigated the molecular and biochemical basis behind such variation, analyzing columbin 32 T. sagittata varieties ranging from 5.40 mg/g to 46.09 mg/g. High low-columbin-content were selected for in-depth transcriptomic untargeted metabolomic analyses. Differential expression patterns of genes metabolites between leaves rhizomes these explored. Results revealed that involved biosynthesis pathway, namely, DXS, DXR, MCS, GPPS, PMK, exhibited significantly higher high At same time, HMGR HDR levels notably lower. Furthermore, columbin-content contained increased isoprene levels, crucial precursor. These findings suggest gene precursor variations likely drive differences insight into clarifies provides valuable direction breeding cultivating varieties, amplifying potential therapeutic applications.

Language: Английский

Citations

0