Potential Biomarkers of Resilience to Microgravity Hazards in Astronauts

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Space exploration exposes astronauts to the unique environment of microgravity, which poses significant health challenges. Identifying biomarkers that can predict an individual's resilience stressors microgravity holds great promise for optimizing astronaut selection and developing personalized countermeasures. This narrative review examines principal risks associated with explores potential indicative resilience. The being evaluated represent a broad spectrum physiological domains, including musculoskeletal, neurological, immunological, gastrointestinal, cardiovascular, cutaneous systems. Earth-based analogs, such as dry immersion head-down tilt bed rest, may provide valuable platforms validate candidate biomarkers. However, biomarker sensitivity specificity must be further ensure efficacy reliability. Establishing panel predictive microgravity-induced would significantly enhance mission success, especially long-duration missions. Insights gained also translate conditions on Earth characterized by reduced physical activity mechanical loading.

Language: Английский

Comparative Analysis of Taste Perception Among Airline Pilots, Construction Workers, and Office Employees

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Objective Occupational exposures may influence gustatory sensations through mechanisms such as fatigue, acute or chronic stress, circadian rhythm disruptions, and exposure to various chemicals. In this cross-sectional study, we sought compare taste perception across three professional groups, namely airline pilots, construction workers, office employees, by assessing identification times for sweet, salty, sour, bitter flavors, alongside salivary pH levels. Methods The study cohort consisted of 90 healthy male participants, with 30 individuals in each occupational group, matched age experience. Salivary was measured using meter paper, whereas were assessed aqueous solutions applied dissolvable strips taste. Results There no significant differences among the groups. However, pilots exhibited a significantly longer time sweet (9.8 ± 3.9 seconds) compared workers (7.0 3.1 seconds, P < 0.05) employees (7.1 3.3 0.05). Conversely, demonstrated prolonged sour (6.1 2.9 (4.2 2.6 (4.6 2.5 No observed salty tastes Conclusion We found particularly concerning tastes. These findings suggest that factors function complex manner. Further research is warranted explore underlying potential implications dietary habits health within specific

Language: Английский