Senolytic therapeutics: An emerging treatment modality for osteoarthritis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102275 - 102275

Published: March 15, 2024

Language: Английский

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Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats

Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Purpose This study aimed to develop a transdermal delivery system for fluocinolone acetonide (FLA), corticosteroid used in treating inflammatory conditions like rheumatoid arthritis (RA), overcome the limitations of oral administration, such as poor solubility and bioavailability. Methods FLA-loaded PEG decorated hyalurosomes (FLA-PHs) were fabricated using ethanol injection, incorporating various Brij® surfactants different amounts hyaluronic acid (HA) based on full factorial design. The impact independent variables, HA amount (mg) (X 1 ) Brij type 2 inspected entrapment efficiency (EE%), particle size (PS), zeta potential (ZP). optimum FLA-PHs then incorporated into ε-polycaprolactone (PCL) cellulose acetate (CA) nanofibers enhance sustained (FLA-NFs). Results exhibited EE% 83.58 ± 0.69%, PS 169.00 1.41 nm, ZP -22.90 0.14 mV. Morphological assessment FLA-NFs showed promising results terms surface roughness. In Freund-induced rat model adjuvant-induced arthritis, treatment with significantly improved joint histopathological analyses. Furthermore, it suppressed markers mTORC1, TNF-α, NF-κB while upregulating TRIM24 anti-inflammatory IL-10. Conclusion present strategy enhancing FLA managing RA, offering improvements efficacy reduced systemic side effects compared conventional administration.

Language: Английский

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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 100 - 120

Published: Jan. 18, 2025

Language: Английский

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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42258 - e42258

Published: Jan. 1, 2025

Language: Английский

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Temporal Transcriptomic Analysis of Periodontal Disease Progression and Its Molecular Links to Systemic Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1998 - 1998

Published: Feb. 25, 2025

Periodontal disease, a prevalent oral inflammatory condition, is implicated in exacerbating systemic diseases. However, the molecular mechanisms underlying this association remain unclear. In study, we performed RNA sequencing of gingival tissue samples collected from mouse model periodontal disease at multiple time points to investigate dynamic transcriptomic changes during progression. Our analysis revealed distinct temporal gene expression patterns associated with key and immune response pathways. These findings suggest stepwise progression process, potentially contributing inflammation through shared signaling networks. We further identified specific genes pathways that may mediate bidirectional relationship between conditions such as cardiovascular diabetes. By elucidating dynamics study provides insights into pathogenesis its implications. It identifies potential biomarkers therapeutic targets for local management.

Language: Английский

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Contributions of Dietary Patterns and Factors to Regulation of Rheumatoid Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2674 - 2674

Published: March 16, 2025

Rheumatoid arthritis (RA) is a systemic autoimmune disease that commonly causes pain in joints and the progressive destruction of cartilage bone, which significantly reduces quality life increases social burden. However, there still no cure for RA, so it highly important to explore additional adjuvant treatment methods. Studies have indicated malnutrition, changes intestinal microbiota, immune status caused by dietary imbalance are directly related onset indicating intervention may offer simple, economical, practical avenue relieve RA. Therefore, this review, we discuss pathogenesis RA summarize influence different patterns on In particular, pointed out high-fat, high-sugar, high-salt diets contribute progression, whereas Mediterranean diet (MD) beneficial preventing Furthermore, ingredients food, such as fiber, probiotics, vitamins, help reduce level inflammation joint pain, play critical roles provides potential effective approach therapy

Language: Английский

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Profile of synovial inflammatory mediators in patients with knee osteoarthritis following SARS-CoV-2 infection

Minerva Biotechnology and Biomolecular Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 1, 2025

Language: Английский

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Vitamin D and Its Role in Rheumatic Diseases

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 259 - 259

Published: April 9, 2025

Vitamin D is a fat-soluble molecule with pleiotropic effects, acting as steroid hormone on three main organs: the intestine, bone, and kidney. Among its best-known functions at skeletal level are regulating bone metabolism mineralization. In 1983, presence of vitamin receptors surface immune cells was described, which led to discovery new immunological inflammatory processes. Currently, we know that modulates adaptative system by suppressing produce cytokines downregulation, an important regulator immunity response. this article, will review synthesis, metabolic pathways, role in rheumatic autoimmune diseases.

Language: Английский

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Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2873 - 2873

Published: March 21, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Recent data underscore oxidative stress as primary factor in the pathophysiology of rheumatoid arthritis, intensifying inflammatory processes tissue damage via overproduction reactive oxygen species (ROS) compromised antioxidant defenses. Current therapies, including disease-modifying antirheumatic drugs (DMARDs), primarily target immune dysregulation but fail to address stress, necessitating novel adjunctive treatment strategies. This review explores potential antioxidant-based therapies complementary approaches RA management. Natural compounds such curcumin, resveratrol, sulforaphane, propolis exhibit strong anti-inflammatory antioxidative properties modulating redox-sensitive pathways, nuclear kappa-light-chain-enhancer activated B cells (NF-κB) erythroid 2-related 2(Nrf2)/heme oxygenase (HO-1). N-acetylcysteine (NAC) replenishes intracellular glutathione, enhancing cellular resilience against stress. Additionally, molecular hydrogen (H2) selectively neutralizes harmful ROS, reducing inflammation. The role vitamin supplementation (D, B12, C, K) regulating responses protecting structures also discussed. aims evaluate efficacy clinical applications RA, emphasizing their mitigating improving outcomes. While preliminary findings are promising, further trials needed establish standardized dosing, long-term safety, integration into current protocols.

Language: Английский

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MMP3 as a Molecular Link: Unraveling the Connection Between Ankylosing Spondylitis and Acute Coronary Syndrome

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 597 - 597

Published: April 15, 2025

Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the joints, limiting patients’ mobility and quality of life. Recent studies have shown patients with AS significantly higher risk developing severe cardiovascular complications, such as acute coronary syndrome (ACS). A comprehensive review (2014–2024) included study evaluating significance matrix metalloproteinase 3 (MMP-3) in among patients. The findings indicate inflammation not only damages joints but also contributes to progression diseases. At molecular level, MMP-3 instrumental degrading extracellular matrix, leading instability atherosclerotic plaques increasing ACS. Additionally, activation related pathways, tumor necrosis factor-alpha (TNF-α) NF-κB, which amplify its effect on both joint destruction vascular damage. This approach offers new perspectives for understanding treating suggesting inhibition could be promising therapeutic strategy mitigate these

Language: Английский

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