Acute alcohol administration dampens central extended amygdala reactivity DOI Creative Commons
Juyoen Hur, Claire M. Kaplan,

Jason F. Smith

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: Nov. 6, 2018

Alcohol use is common, imposes a staggering burden on public health, and often resists treatment. The central extended amygdala (EAc)-including the bed nucleus of stria terminalis (BST) (Ce)-plays key role in prominent neuroscientific models alcohol drinking, but relevance these regions to acute consumption humans remains poorly understood. Using single-blind, randomized-groups design, multiband fMRI data were acquired from 49 social drinkers while they performed well-established emotional faces paradigm after consuming either or placebo. Relative placebo, significantly dampened reactivity BST. To rigorously assess potential regional differences activation, extracted unbiased, anatomically predefined interest. Analyses revealed similar levels dampening BST Ce. In short, transiently reduces it does so similarly across two major divisions human EAc. These observations reinforce translational addiction derived preclinical work rodents provide new insights into neural systems most relevant initial development abuse humans.

Language: Английский

Dispositional negativity: An integrative psychological and neurobiological perspective. DOI Creative Commons
Alexander J. Shackman, Do Tromp, Melissa D. Stockbridge

et al.

Psychological Bulletin, Journal Year: 2016, Volume and Issue: 142(12), P. 1275 - 1314

Published: Oct. 11, 2016

Dispositional negativity-the propensity to experience and express more frequent, intense, or enduring negative affect-is a fundamental dimension of childhood temperament adult personality. Elevated levels dispositional negativity can have profound consequences for health, wealth, happiness, drawing the attention clinicians, researchers, policymakers. Here, we highlight recent advances in our understanding psychological neurobiological processes linking stable individual differences momentary emotional states. Self-report data suggest that 3 key pathways-increased stressor reactivity, tonic increases affect, increased exposure-explain most heightened affect characterizes individuals with disposition. Of these pathways, tonically elevated, indiscriminate appears be central daily life relevant development psychopathology. New behavioral biological provide insights into neural systems underlying pathways motivate hypothesis seemingly "tonic" may actually reflect reactivity stressors are remote, uncertain, diffuse. Research focused on humans, monkeys, rodents suggests this reflects trait-like variation activity connectivity several brain regions, including extended amygdala parts prefrontal cortex. Collectively, observations an integrative psychobiological framework dynamic cascade bind traits states and, ultimately, disorders other kinds adverse outcomes. (PsycINFO Database Record

Language: Английский

Citations

223
The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research DOI
Andrew S. Fox, Alexander J. Shackman

Neuroscience Letters, Journal Year: 2017, Volume and Issue: 693, P. 58 - 67

Published: Nov. 30, 2017

Language: Английский

Citations

197
Neural correlates of emotion-attention interactions: From perception, learning, and memory to social cognition, individual differences, and training interventions DOI Creative Commons
Florin Dolcos, Yuta Katsumi, Matthew Moore

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 108, P. 559 - 601

Published: Aug. 22, 2019

Due to their ability capture attention, emotional stimuli tend benefit from enhanced perceptual processing, which can be helpful when such are task-relevant but hindering they task-irrelevant. Altered emotion-attention interactions have been associated with symptoms of affective disturbances, and emerging research focuses on improving prevent or treat disorders. In line the Human Affectome Project's emphasis linguistic components, we also analyzed language used describe attention-related aspects emotion, highlighted terms related domains as conscious awareness, motivational effects social emotion regulation. These were discussed within a broader review available evidence regarding neural correlates (1) Emotion-Attention Interactions in Perception, (2) Learning Memory, (3) Individual Differences Interactions, (4) Training Interventions Optimize Interactions. This comprehensive approach enabled an integrative overview current knowledge mechanisms at multiple levels analysis, identification directions for future investigations.

Language: Английский

Citations

176
Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat DOI Creative Commons
Daniel M. Stout, Alexander J. Shackman, Walker S. Pedersen

et al.

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: Aug. 14, 2017

Dispositional anxiety is a trait-like phenotype that confers increased risk for range of debilitating neuropsychiatric disorders. Like many patients with disorders, individuals elevated levels dispositional are prone to intrusive and distressing thoughts in the absence immediate threat. Recent electrophysiological research suggests these symptoms rooted mis-allocation working memory (WM) resources threat-related information. Here, functional MRI was used identify network brain regions support WM faces quantify allocation neural distracters 81 young adults. Results revealed widespread evidence mis-allocation. This evident both face-selective fusiform cortex domain-general prefrontal parietal cortices. bias exaggerated among more anxious disposition. Mediation analyses provided compelling individuals' tendency mis-allocate statistically explained by heightened amygdala reactivity. Collectively, results provide neurocognitive framework understanding pathways linking phenotypes development internalizing psychopathology set stage developing improved intervention strategies.

Language: Английский

Citations

125
Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament DOI Open Access
Andrew S. Fox, Jonathan A. Oler, Rasmus M. Birn

et al.

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(35), P. 7611 - 7621

Published: July 30, 2018

Children with an extremely inhibited, anxious temperament (AT) are at increased risk for anxiety disorders and depression. Using a rhesus monkey model of early-life AT, we previously demonstrated that metabolism in the central extended amygdala (EAc), including nucleus (Ce) bed stria terminalis (BST), is associated trait-like variation AT. Here, use fMRI to examine relationships between Ce–BST functional connectivity AT large multigenerational family pedigree monkeys (n = 170 females 208 males). Results demonstrate heritable, accounts significant but modest portion variance coheritable Interestingly, AT-related BST were not correlated accounted non-overlapping Exploratory analyses suggest hypothalamus periaqueductal gray. Together, these results importance coordinated function within EAc determining individual differences brain regions its behavioral neuroendocrine components. SIGNIFICANCE STATEMENT Anxiety directly impact lives nearly one five people, accounting substantial worldwide suffering disability. nonhuman primate understand neurobiology underlying develop disorders. Leveraging same kinds neuroimaging measures routinely used human studies, activation with, coinherited Understanding how work together produce extreme provides neural target interventions promise preventing lifelong disability at-risk children.

Language: Английский

Citations

125
Better Safe Than Sorry: A Common Signature of General Vulnerability for Psychopathology DOI
Omer Van den Bergh, J. F. Brosschot, Hugo Critchley

et al.

Perspectives on Psychological Science, Journal Year: 2020, Volume and Issue: 16(2), P. 225 - 246

Published: Oct. 2, 2020

Several labels, such as neuroticism, negative emotionality, and dispositional negativity, indicate a broad dimension of psychopathology. However, largely separate, often disorder-specific research lines have developed that focus on different cognitive affective characteristics are associated with this dimension, perseverative cognition (worry, rumination), reduced autobiographical memory specificity, compromised fear learning, enhanced somatic-symptom reporting. In article, we present theoretical perspective within predictive-processing framework in which trace these phenotypically back to common underlying “better-safe-than-sorry” processing strategy. This implies information tends be low sensory-perceptual detail, allows threat-related categorical priors dominate conscious experience for chronic uncertainty/surprise because stagnated error-reduction process. information-processing strategy has beneficial effects the short term but important costs long term. From perspective, suggest phenomenally distinct psychopathological mentioned above represent same basic heuristic brain only relation particular type involved (e.g., working memory, external internal world). Clinical implications view discussed.

Language: Английский

Citations

105
Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework DOI
Juyoen Hur, Melissa D. Stockbridge, Andrew S. Fox

et al.

Progress in brain research, Journal Year: 2019, Volume and Issue: unknown, P. 375 - 436

Published: Jan. 1, 2019

Language: Английский

Citations

84
The Amygdala and Depression: A Sober Reconsideration DOI
Shannon E. Grogans, Andrew S. Fox, Alexander J. Shackman

et al.

American Journal of Psychiatry, Journal Year: 2022, Volume and Issue: 179(7), P. 454 - 457

Published: July 1, 2022

Language: Английский

Citations

51
Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum DOI Creative Commons
Rany Abend

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105305 - 105305

Published: July 5, 2023

Language: Английский

Citations

42
Annual Research Review: Neuroimmune network model of depression: a developmental perspective DOI Creative Commons
Robin Nusslock, Lauren B. Alloy, Gene H. Brody

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2024, Volume and Issue: 65(4), P. 538 - 567

Published: March 1, 2024

Depression is a serious public health problem, and adolescence an ‘age of risk’ for the onset Major Depressive Disorder. Recently, we others have proposed neuroimmune network models that highlight bidirectional communication between brain immune system in both mental physical health, including depression. These draw on research indicating cellular actors (particularly monocytes) signaling molecules cytokines) orchestrate inflammation periphery can directly modulate structure function brain. In brain, inflammatory activity heightens sensitivity to threats cortico‐amygdala circuit, lowers rewards cortico‐striatal alters executive control emotion regulation prefrontal cortex. When dysregulated, particularly under conditions chronic stress, generate feelings dysphoria, distress, anhedonia. This initiate unhealthy, self‐medicating behaviors (e.g. substance use, poor diet) manage which further heighten inflammation. Over time, dysregulation these circuits response may compound each other form positive feedback loop, whereby one organ exacerbates other. We suggest this dynamic joint vulnerability depression, during adolescence. three goals present paper. First, extend developmental framework risk depression Second, examine how perspective help explain high rates comorbidity psychiatric disorders across development, multimorbidity stress‐related medical illnesses. Finally, consider identifying pathways facilitate ‘next generation’ behavioral biological interventions target treat, ideally prevent, youth adolescents.

Language: Английский

Citations

12