Acute alcohol administration dampens central extended amygdala reactivity DOI Creative Commons
Juyoen Hur, Claire M. Kaplan,

Jason F. Smith

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: Nov. 6, 2018

Alcohol use is common, imposes a staggering burden on public health, and often resists treatment. The central extended amygdala (EAc)-including the bed nucleus of stria terminalis (BST) (Ce)-plays key role in prominent neuroscientific models alcohol drinking, but relevance these regions to acute consumption humans remains poorly understood. Using single-blind, randomized-groups design, multiband fMRI data were acquired from 49 social drinkers while they performed well-established emotional faces paradigm after consuming either or placebo. Relative placebo, significantly dampened reactivity BST. To rigorously assess potential regional differences activation, extracted unbiased, anatomically predefined interest. Analyses revealed similar levels dampening BST Ce. In short, transiently reduces it does so similarly across two major divisions human EAc. These observations reinforce translational addiction derived preclinical work rodents provide new insights into neural systems most relevant initial development abuse humans.

Language: Английский

Disentangling the Role of Different Resting-State Neural Markers of Adolescent Behavioral Inhibition and Social Anxiety DOI Creative Commons
Madison Politte‐Corn, Sarah Myruski,

Bridget Cahill

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101560 - 101560

Published: April 24, 2025

Language: Английский

Citations

0
Extended‐amygdala intrinsic functional connectivity networks: A population study DOI Creative Commons
Samuel C. Berry, Richard G. Wise, Andrew D. Lawrence

et al.

Human Brain Mapping, Journal Year: 2020, Volume and Issue: 42(6), P. 1594 - 1616

Published: Dec. 12, 2020

Abstract Pre‐clinical and human neuroimaging research implicates the extended‐amygdala (ExtA) (including bed nucleus of stria terminalis [BST] central amygdala [CeA]) in networks mediating negative emotional states associated with stress substance‐use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised large sample ( n > 1,000 healthy young adult humans) compare intrinsic functional connectivity (ICNs) BST CeA using task‐free magnetic resonance imaging (fMRI) data from Human Connectome Project. assessed whether inter‐individual differences within these ICNs were related two principal components representing disposition alcohol use. Building on recent primate evidence, we tested BST‐CeA (iFC) was heritable further examined co‐heritability our components. demonstrate have discrete, but largely overlapping similar previous findings. found no evidence that BST—CeA iFC heritable; however, post hoc analyses significant heritability broader superficial centromedial regions. There correlations or associations either across for specific BST‐Amygdala iFC. Possible phenotype task‐free, task‐based, clinical fMRI are discussed, along suggestions more causal investigative paradigms make use now well‐established ICNs.

Language: Английский

Citations

24
Insomnia and distress as mediators on the relationship from cyber-victimization to self-reported psychotic experiences: a binational study from Tunisia and Lebanon DOI Creative Commons
Feten Fekih‐Romdhane,

Manel Stambouli,

Diana Malaeb

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 20, 2023

Abstract Background While expansive research has accumulated concerning the association between traditional, face-to-face peer victimization and psychosis, a paucity of empirical been undertaken so far to investigate these associations with experiences new evolving ways through digital world. Exploring is highly relevant timely, given that emerging adults are heavy users technologies, exposed online risks, at peak age onset psychosis. This study aimed test hypothesis psychological distress insomnia symptoms have significant indirect mediating effect on cyber-victimization self-reported positive psychotic (SRPEs) in binational sample Tunisian Lebanese community adults. Method The total was composed 3766 participants; 3103 were from Lebanon (Mean age: 21.73 ± 3.80 years, 63.6% females) 663 Tunisia 26.32 4.86 59.9% females). Online anonymous self-report questionnaires administered all participants. Results Higher SRPEs found participants compared Tunisians, single married ones, those university level education secondary or less, who live rural areas urban, do not smoke, drink alcohol use marijuana any other illegal drug. Furthermore, more cyber-victimization, higher severity significantly associated SRPEs. After adjusting for potential confounders, mediation analysis demonstrated severity/psychological distress; which were, turn, greater Finally, directly dimension. Conclusion Identifying as mediators could provide novel insight psychosis prevention efforts intervention targets cyber-victimized individuals prone experience subclinical symptoms.

Language: Английский

Citations

9
An Honest Reckoning With the Amygdala and Mental Illness DOI
Andrew S. Fox, Alexander J. Shackman

American Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 181(12), P. 1059 - 1075

Published: Dec. 1, 2024

Anxiety disorders are a leading source of human misery, morbidity, and premature mortality. Existing treatments far from curative for many, underscoring the need to clarify underlying neural mechanisms. Although many brain regions contribute, amygdala has received most intense scientific attention. Over past several decades, this scrutiny yielded detailed understanding function, but it failed produce new clinical assays, biomarkers, or cures. Rising urgent public health challenge demands an honest reckoning with functional-neuroanatomical complexity shift theories anchored on "the amygdala" models centered specific nuclei cell types. This review begins by examining evidence studies rodents, monkeys, humans "canonical model," idea that plays central role in fear- anxiety-related states, traits, disorders. Next, authors selectively highlight work indicating canonical model, while true, is overly simplistic fails adequately capture actual state evidentiary record, breadth amygdala-associated functions illnesses, amygdala's functional architecture. The describe implications these facts basic neuroimaging research. concludes some general recommendations grappling accelerating efforts understand more effectively treat amygdala-related psychopathology.

Language: Английский

Citations

3
Acute alcohol administration dampens central extended amygdala reactivity DOI Creative Commons
Juyoen Hur, Claire M. Kaplan,

Jason F. Smith

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: Nov. 6, 2018

Alcohol use is common, imposes a staggering burden on public health, and often resists treatment. The central extended amygdala (EAc)-including the bed nucleus of stria terminalis (BST) (Ce)-plays key role in prominent neuroscientific models alcohol drinking, but relevance these regions to acute consumption humans remains poorly understood. Using single-blind, randomized-groups design, multiband fMRI data were acquired from 49 social drinkers while they performed well-established emotional faces paradigm after consuming either or placebo. Relative placebo, significantly dampened reactivity BST. To rigorously assess potential regional differences activation, extracted unbiased, anatomically predefined interest. Analyses revealed similar levels dampening BST Ce. In short, transiently reduces it does so similarly across two major divisions human EAc. These observations reinforce translational addiction derived preclinical work rodents provide new insights into neural systems most relevant initial development abuse humans.

Language: Английский

Citations

27