Obesity in the 21st Century. Prevalence, Phenotypes, Course Variants and Consequences DOI Open Access
И. Т. Муркамилов, D. Ymankulov, А. И. Сабирова

et al.

Bulletin of Science and Practice, Journal Year: 2024, Volume and Issue: 10(4), P. 268 - 303

Published: April 15, 2024

The review article examines the issues of obesity regarding its prevalence, phenotypes, course and consequences. anatomical, physiological functional features adipose tissue are discussed. “Discussion” section presents authors’ own clinical observations on therapeutic surgical in treatment obesity. Currently, is divided into white, brown beige. White can turn each other through beige stage. volume activity require greater expenditure metabolism oxygen molecules more pronounced women. components extracellular matrix collagen types I, III, V, VI. structure varies depending location, size fat, age, gender, state kidneys, thyroid gland, nature food, energy sleep patterns. With intense work cold exposure, hormone irisin formed skeletal muscles, which promotes transformation white or beige, helps reduce body weight obesity, has a beneficial effect type 2 diabetes mellitus associated diseases. Traditionally, obese individuals metabolically healthy unhealthy based degree metabolic disorders. In visceral lipolysis occurs with high intensity, supports development inflammation. decreased expression adiponectin accelerates atherosclerotic cardiovascular As increases, acquires an inflammatory phenotype, manifested by increased cytokines (interleukin-6, interleukin-1, interleukin-17, tumor necrosis factor-alpha), hyperactivation renin-angiotensin-aldosterone system, as well excessive cell infiltration immune system (leukocytes, neutrophils, T-lymphocytes, monocytes, macrophages). During inflammation tissue, (M1) atherogenic (M4) phenotypes macrophages dominate. morbid number reach up to 50% all cells.

Language: Английский

Obesity in the 21st Century. Prevalence, Phenotypes, Course Variants and Consequences DOI Open Access
И. Т. Муркамилов, D. Ymankulov, А. И. Сабирова

et al.

Bulletin of Science and Practice, Journal Year: 2024, Volume and Issue: 10(4), P. 268 - 303

Published: April 15, 2024

The review article examines the issues of obesity regarding its prevalence, phenotypes, course and consequences. anatomical, physiological functional features adipose tissue are discussed. “Discussion” section presents authors’ own clinical observations on therapeutic surgical in treatment obesity. Currently, is divided into white, brown beige. White can turn each other through beige stage. volume activity require greater expenditure metabolism oxygen molecules more pronounced women. components extracellular matrix collagen types I, III, V, VI. structure varies depending location, size fat, age, gender, state kidneys, thyroid gland, nature food, energy sleep patterns. With intense work cold exposure, hormone irisin formed skeletal muscles, which promotes transformation white or beige, helps reduce body weight obesity, has a beneficial effect type 2 diabetes mellitus associated diseases. Traditionally, obese individuals metabolically healthy unhealthy based degree metabolic disorders. In visceral lipolysis occurs with high intensity, supports development inflammation. decreased expression adiponectin accelerates atherosclerotic cardiovascular As increases, acquires an inflammatory phenotype, manifested by increased cytokines (interleukin-6, interleukin-1, interleukin-17, tumor necrosis factor-alpha), hyperactivation renin-angiotensin-aldosterone system, as well excessive cell infiltration immune system (leukocytes, neutrophils, T-lymphocytes, monocytes, macrophages). During inflammation tissue, (M1) atherogenic (M4) phenotypes macrophages dominate. morbid number reach up to 50% all cells.

Language: Английский

Citations

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