International Journal of experimental research and review, Journal Year: 2024, Volume and Issue: 37, P. 149 - 158
Published: March 30, 2024
In the twenty-first century, there have been a number of outbreaks, beginning with dengue, swine flu, Nipah, Ebola, chikungunya, and Zika, which were continuously outbreaks in some specific regions. The mosquito-transmitted flavivirus Japanese encephalitis (JE) virus, similar to dengue fever West Nile viruses, negative-single-stranded Ebola virus (EBOV) are two most emerging WHO's most-prioritized diseases. Natural products always served as an alternative mainstream drugs emergencies. Thus, due their excellent antiviral activity, present study focused on marine alkaloids assessed potency against JE EBOV viruses. Using various bioinformatics tools, we selected 60 different for anti-JE activity RNA-dependent RNA polymerase (PDB ID: 4HDG), NS3-helicase 2Z83), NS5-protease 4K6M), well anti-EBOV efficacy targeting nucleoprotein 4Z9P), viral protein 24 4M0Q), 40 3TCQ). Based previous records combined molecular docking scores, physicochemical, toxicity, pharmacokinetic, drug-ability profiles, researchers concluded that manzamines A, F, X 6-deoxymanzamine 8-hydroxymanzamine may be best among all candidates EV infection control. summary, exhibit need explored more bioactive drug discovery, where tools cost-effective, resource-efficient, time-saving platform than traditional discovery modules locate lead used medicine health conditions.
Language: Английский