Protein Immobilization on Bacterial Cellulose for Biomedical Application DOI Open Access
Anastasia N. Shishparenok,

Vitalina V. Furman,

Natalia V. Dobryakova

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2468 - 2468

Published: Aug. 30, 2024

New carriers for protein immobilization are objects of interest in various fields biomedicine. Immobilization is a technique used to stabilize and provide physical support biological micro- macromolecules whole cells. Special efforts have been made develop new materials that non-toxic both the body environment, inexpensive, readily available, easy modify. Currently, biodegradable polymers, including cellulose, widely immobilization. Bacterial cellulose (BC) natural polymer with excellent biocompatibility, purity, high porosity, water uptake capacity, non-immunogenicity, ease production modification. BC composed glucose units does not contain lignin or hemicellulose, which an advantage allowing avoidance chemical purification step before use. Recently, BC-protein composites developed as wound dressings, tissue engineering scaffolds, three-dimensional (3D) cell culture systems, drug delivery enzyme matrices. Proteins peptides often added polymeric scaffolds improve their biocompatibility biological, physical-chemical, mechanical properties. To broaden applications, ex situ modifications native its properties specific application. In vivo studies showed several exhibited demonstrated prolonged treatment time, increased survival animals. Today, there patents commercial BC-based wounds vascular grafts. Therefore, further research on has great prospects. This review focuses major advances biomedical applications.

Language: Английский

Protein Immobilization on Bacterial Cellulose for Biomedical Application DOI Open Access
Anastasia N. Shishparenok,

Vitalina V. Furman,

Natalia V. Dobryakova

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2468 - 2468

Published: Aug. 30, 2024

New carriers for protein immobilization are objects of interest in various fields biomedicine. Immobilization is a technique used to stabilize and provide physical support biological micro- macromolecules whole cells. Special efforts have been made develop new materials that non-toxic both the body environment, inexpensive, readily available, easy modify. Currently, biodegradable polymers, including cellulose, widely immobilization. Bacterial cellulose (BC) natural polymer with excellent biocompatibility, purity, high porosity, water uptake capacity, non-immunogenicity, ease production modification. BC composed glucose units does not contain lignin or hemicellulose, which an advantage allowing avoidance chemical purification step before use. Recently, BC-protein composites developed as wound dressings, tissue engineering scaffolds, three-dimensional (3D) cell culture systems, drug delivery enzyme matrices. Proteins peptides often added polymeric scaffolds improve their biocompatibility biological, physical-chemical, mechanical properties. To broaden applications, ex situ modifications native its properties specific application. In vivo studies showed several exhibited demonstrated prolonged treatment time, increased survival animals. Today, there patents commercial BC-based wounds vascular grafts. Therefore, further research on has great prospects. This review focuses major advances biomedical applications.

Language: Английский

Citations

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