Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH DOI Creative Commons
Nune Darbinian, Nana Merabova,

Gabriel Tatevosian

et al.

Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 2 - 2

Published: Dec. 19, 2023

Introduction: Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and affective dysregulation, including hyperactivity depression. The mechanisms are not known, but they could conceivably be due to postnatal social or environmental factors. However, we postulate that, more likely, the dysregulation is associated effects of EtOH exposure on development serotonergic (5-HT) and/or dopaminergic (DA) pathways, i.e., pathways that in life believed regulate mood. Many women who use (ethanol, EtOH) during pregnancy suffer from depression take selective serotonin reuptake inhibitors (SSRIs), which might influence these monoaminergic fetus. Alternatively, pathway abnormalities reflect a direct effect brain. To distinguish between possibilities, measured their expressions brains brain-derived exosomes (FB-Es) isolated mothers’ blood. We hypothesized maternal SSRIs would impaired neural development, detectable as abnormal levels apoptotic biomarkers FB-Es. Methods: Fetal brain tissues blood were collected at 9–23 weeks pregnancy. groups compared unexposed controls matched for gestational age (GA). expression 84 genes DA 5-HT was analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) microarrays. FB-Es also assayed transporter protein (SERT) neurotrophic factor (BDNF) enzyme-linked immunosorbent assay (ELISA). Results: Six EtOH-exposed human samples SSRI- polydrug-exposed controls. significant upregulation receptor D3 HTR2C, while HTR3A downregulated. Monoamine oxidase A (MAOA), MAOB, serine/threonine kinase AKT3, caspase-3 upregulated, mitogen-activated 1 (MAPK1) AKT2 ETOH gene, SERT There correlations (a) activation, (b) reduced levels, (c) BDNF levels. SSRI independently increased activity downregulated BDNF. Early together synergistically downregulation Reduced strongly correlated reduction eye diameter, somatic manifestation FASD. Conclusions: Maternal each changes monoamine consistent potential

Language: Английский

Health concerns associated with biogenic amines in food and interaction with amine oxidase drugs DOI
Bruno Martins Dala Paula, Flávia Beatriz Custódio,

Maria BA Gloria

et al.

Current Opinion in Food Science, Journal Year: 2023, Volume and Issue: 54, P. 101090 - 101090

Published: Sept. 14, 2023

Language: Английский

Citations

28
The Resurgence of Synthetic Cannabinoid Receptor Agonists as Adulterants in the Era of Cannabis Legalization: Lessons from Prior Epidemics and Clinical Implications DOI
Aaron P. Jones, Ali S. Taha, Grover P. Miller

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106043 - 106043

Published: Feb. 1, 2025

Language: Английский

Citations

1
A fatal intoxication case due to the serotonin syndrome induced by dextromethorphan and moclobemide overdose DOI
Takahiro Harada,

Akira Namera,

Naoki Nakao

et al.

Legal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102604 - 102604

Published: Feb. 1, 2025

Language: Английский

Citations

1
Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators DOI Creative Commons
Yifan Ma,

H.S. Chen,

Hui Li

et al.

Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(3)

Published: Feb. 13, 2024

Abstract Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme present in almost all vertebrate tissues that catalyzes the degradation of biogenic and dietary-derived monoamines. MAOA known for regulating neurotransmitter metabolism has been implicated antitumor immune responses. In this review, we retrospect inhibits activities various types tumor-associated cells (such as CD8 + T macrophages) by their intracellular monoamines metabolites. Developing novel inhibitor drugs exploring multidrug combination strategies may enhance efficacy governance. Thus, act checkpoint or immunomodulator influencing effectiveness immunotherapy. conclusion, promising target merits further in-depth exploration preclinical clinical settings.

Language: Английский

Citations

7
Tyramine, a biogenic agent in cheese: amount and factors affecting its formation, a systematic review DOI Creative Commons

Parisa Sadighara,

Saeed Aghebat- Bekheir, Hamed Shafaroodi

et al.

Food Production Processing and Nutrition, Journal Year: 2024, Volume and Issue: 6(1)

Published: March 6, 2024

Abstract Tyramine is one of the most important biological amines in food, which leads to food poisoning if consumed high amounts. In addition poisoning, tyramine drug interactions. Foods can cause blood pressure and migraines people taking monoamine oxidase (MAO) inhibitors. Therefore, MAO inhibitors should avoid foods tyramine. Cheese provides ideal conditions for production Some cheeses contain amounts lead unwanted effects These are called cheese effect or interaction. Considering importance subject, a systematic study was designed with aim determining amount effective factors on production. The search done three databases, including Scopus, PubMed, Science Direct. conducted two phases. first stage, reported cheeses, analytical method, measurement, characteristics were discussed. second phase, influencing its formation investigated. Based extracted data, levels ranged from 3.23 1398 mg/kg. method measuring studies HPLC method. According detailed review literature, included bacterial species, animal storage (time temperature), pH, moisture, salt, number somatic cells. Basically, by identifying affecting it possible control Graphical

Language: Английский

Citations

6
General Treatments Promoting Independent Living in Parkinson’s Patients and Physical Therapy Approaches for Improving Gait—A Comprehensive Review DOI Creative Commons

Dae-Hwan Lee,

Bong-Sik Woo,

Yong‐Hwa Park

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 711 - 711

Published: April 25, 2024

This study delves into the multifaceted approaches to treating Parkinson's disease (PD), a neurodegenerative disorder primarily affecting motor function but also manifesting in variety of symptoms that vary greatly among individuals. The complexity PD necessitates comprehensive treatment strategy integrates surgical interventions, pharmacotherapy, and physical therapy tailor unique needs each patient. Surgical options, such as deep brain stimulation (DBS), have been pivotal for patients not responding adequately medication, offering significant symptom relief. Pharmacotherapy remains cornerstone management, utilizing drugs like levodopa, dopamine agonists, others manage and, some cases, slow down progression. However, these treatments often lead complications over time, fluctuations dyskinesias, highlighting need precise dosage adjustments sometimes combination therapies optimize patient outcomes. Physical plays critical role addressing PD, including bradykinesia, muscle rigidity, tremors, postural instability, akinesia. PT techniques are tailored improve mobility, balance, strength, overall quality life. Strategies gait balance training, strengthening exercises, stretching, functional training employed mitigate enhance independence. Specialized proprioceptive neuromuscular facilitation (PNF), Bobath concept, use assistive devices integral rehabilitation process, aimed at improving patients' ability perform daily activities reducing risk falls. Innovations technology introduced robotic-assisted (RAGT) other devices, new possibilities care. These tools provide targeted support feedback, allowing more intensive personalized sessions. Despite advancements, high costs accessibility issues remain challenges addressing. inclusion exercise activity beyond structured sessions is encouraged, with evidence suggesting regular can neuroprotective effects, potentially slowing Activities treadmill walking, cycling, aquatic exercises only contribute emotional well-being social interactions. In conclusion, requires holistic approach combines medical, surgical, therapeutic strategies. While there no cure, goal maximize abilities life through plans. integrated approach, along ongoing research development therapies, offers hope management lives those affected by this challenging disease.

Language: Английский

Citations

6
Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors DOI Creative Commons

Jayalakshmi Jayan,

Namitha Chandran,

Amrutha Chandran Thekkantavida

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(41), P. 37731 - 37751

Published: Oct. 3, 2023

The monoamine oxidase enzyme (MAO), which is bound on the membrane of mitochondria, catalyzes oxidative deamination endogenous and exogenous monoamines, including neurotransmitters such as serotonin, adrenaline, dopamine. These enzymes have been proven to play a significant role in neurodegeneration; thus, they recently researched prospective therapeutic targets for neurodegenerative illness treatment management. MAO inhibitors already marketed neurodegeneration treatments despite their substantial side effects. Hence, researchers are concentrating developing novel molecules with selective reversible inhibitory properties. Piperine, phytochemical component present black pepper, has established potent inhibitor. Piperine encompasses piperidine nucleus antibacterial, anti-inflammatory, antihypertensive, anticonvulsant, antimalarial, antiviral, anticancer current Review focuses structural changes structure–activity relationships derivatives inhibitors.

Language: Английский

Citations

13
Antidepressants and Weight Gain: An Update on the Evidence and Clinical Implications DOI

Lauren Moss,

Marci Laudenslager,

Kristine J. Steffen

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

Citations

0
The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment DOI

Lila Agbaria,

Foad Mirzaei,

Nathalie Omar A'amar

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Monoamine Oxidase Inhibitors Present in Tobacco Modulate Dopamine Balance Via the Dopamine Transporter DOI Creative Commons
Gabriella Sarò,

Stéphanie Johne,

Diogo A. R. S. Latino

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

It has been reported that nicotine affects brain dopamine homeostasis. By binding to nicotinic acetylcholine receptors, including those expressed by dopaminergic neurons of the ventral tegmental area, stimulates release and signaling. Dopamine is taken up from synaptic cleft transporter (DAT) into presynaptic neurons, where it degraded monoamine oxidase (MAO). Besides nicotine, other tobacco compounds play a role in modulation. To better understand biological effects on regulation, we selected group based their potential affinity bind human MAO-A MAO-B enzymes using an silico approach. Subsequently, tested putative enzymatic assay verify ability inhibit or MAO-B. The positive hits were harman, norharman, harmaline, 1-ethyl-β-carboline. While harman norharman have extensively studied, both harmaline 1-ethyl-β-carboline not described context MAO inhibition before. We investigated DAT activity overexpressing cell line uptake rat striatal synaptosomes. clearly demonstrate inhibitors (MAO-AIs) significantly attenuated consequent uptake, establishing functional connection between MAOIs via DAT. Interestingly, MAO-AIs elicited pronounced crude synaptosomal preparations. In summary, this vitro study demonstrates found cigarette smoke only reduce but also strongly impact homeostatic mechanisms Further vivo investigations would advance our understanding underlying regulation

Language: Английский

Citations

0