Autism Spectrum Disorder: Brain Areas Involved, Neurobiological Mechanisms, Diagnoses and Therapies
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2423 - 2423
Published: Feb. 19, 2024
Autism
spectrum
disorder
(ASD),
affecting
over
2%
of
the
pre-school
children
population,
includes
an
important
fraction
conditions
accounting
for
heterogeneity
autism.
The
disease
was
discovered
75
years
ago,
and
present
review,
based
on
critical
evaluations
recognized
ASD
studies
from
beginning
1990,
has
been
further
developed
by
comparative
analyses
research
clinical
reports,
which
have
grown
progressively
in
recent
up
to
late
2023.
tools
necessary
identification
its
related
pathologies
are
genetic
epigenetic
mutations
affected
specific
interaction
with
transcription
factors
chromatin
remodeling
processes
occurring
within
complexes
brain
neurons.
Most
often,
ensuing
effects
induce
inhibition/excitation
synaptic
structures
sustained
primarily,
at
dendritic
fibers,
alterations
flat
spine
response
sites.
These
relevant
because
synapses,
established
interactions
neurons
glial
cells,
operate
as
early
key
targets
ASD.
pathology
is
often
suspected
parents
communities
then
confirmed
experiences.
final
diagnoses
mature
patients
completed
combination
neuropsychological
(cognitive)
tests
electro-/magneto-encephalography
specialized
centers.
comorbidities,
induced
such
anxieties,
depressions,
hyperactivities,
sleep
defects,
interact
reinforce
other
diseases,
especially
schizophrenia.
Advanced
therapies,
prescribed
adult
control
symptoms
disease,
well-known
drugs
classical
neurologic
psychiatric
practice.
Overall,
this
review
reports
discusses
advanced
knowledge
about
biological
medical
properties
Language: Английский
Autism Detection in Children: Integrating Machine Learning and Natural Language Processing in Narrative Analysis
Behavioral Sciences,
Journal Year:
2024,
Volume and Issue:
14(6), P. 459 - 459
Published: May 29, 2024
Despite
the
consensus
that
early
identification
leads
to
better
outcomes
for
individuals
with
autism
spectrum
disorder
(ASD),
recent
research
reveals
average
age
of
diagnosis
in
Greek
population
is
approximately
six
years.
However,
this
delayed
by
an
additional
two
years
families
from
lower-income
or
minority
backgrounds.
These
disparities
result
adverse
impacts
on
intervention
outcomes,
which
are
further
burdened
often
time-consuming
and
labor-intensive
language
assessments
children
ASD.
There
a
crucial
need
tools
increase
access
assessment
will
be
rigorous
objective.
The
current
study
leverages
capabilities
artificial
intelligence
develop
reliable
practical
model
distinguishing
ASD
typically-developing
peers
based
their
narrative
vocabulary
skills.
We
applied
natural
processing-based
extraction
techniques
automatically
acquire
features
(narrative
skills)
storytelling
68
52
children,
then
trained
machine
learning
models
children’s
combined
expressive
data
generate
behavioral
targets
effectively
differentiate
children.
According
findings,
could
distinguish
achieving
accuracy
96%.
Specifically,
out
used,
hist
gradient
boosting
XGBoost
showed
slightly
superior
performance
compared
decision
trees
models,
particularly
regarding
F1
score.
results
bode
well
deployment
technology
ASD,
especially
those
limited
services.
Language: Английский
Emotion recognition and social functioning in individuals with autism spectrum condition and intellectual disability
Daniela Tamaš,
No information about this author
Nina Brkić Jovanović,
No information about this author
S Stojkov
No information about this author
et al.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(3), P. e0300973 - e0300973
Published: March 21, 2024
Objective
Most
previous
studies
have
examined
emotion
recognition
in
autism
spectrum
condition
(ASC)
without
intellectual
disability
(ID).
However,
ASC
and
ID
co-occur
to
a
high
degree.
The
main
aims
of
the
study
were
examine
individuals
with
co-occurring
(ASC-ID)
as
compared
alone,
investigate
relationship
between
social
functioning.
Methods
sample
consisted
30
adult
participants
ASC-ID
comparison
group
29
ID.
Emotion
was
assessed
by
facial
emotions
test,
while.
functioning
responsiveness
scale–second
edition
(SRS-2).
Results
accuracy
significantly
lower
control
ID,
especially
when
it
came
identifying
angry
fearful
emotions.
Participants
exhibited
more
pronounced
difficulties
those
there
significant
negative
correlation
accounted
for
only
8%
variability
observed
Conclusion
Our
data
indicate
severe
social-perceptual
domain
everyday
ASC-ID.
Language: Английский
Pragmatic competence in people with dual diagnosis: down syndrome and autism spectrum disorder
BMC Psychology,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Feb. 15, 2024
Abstract
Background
Pragmatics
is
an
area
that
can
be
affected
in
a
wide
variety
of
disorders.
In
this
sense,
Syndromic
Autism
defined
as
disorder
which
causal
link
established
between
associated
syndrome
and
Spectrum
Disorder
(ASD).
Likewise,
Down
Syndrome
(DS)
one
the
main
genetically
based
syndromes
ASD
described
its
possible
manifestations.
direction,
people
with
DS
are
social
beings
whereas
there
seems
to
specific
alteration
domain.
Methods
study,
pragmatic
performance
was
analysed
sample
72
participants,
where
comparisons
were
made
scores
obtained
by
children
(n
=
24),
24)
+
24).
Results
The
Social
Communication
Questionnaire
(SCQ),
Block
Objective
Criterial
Language
Battery
(BLOC-SR)
Neuropsychology
subtest
(NEPSY-II)
aimed
at
Theory
Mind
(ToM)
identified
significant
differences
groups.
However,
two-to-two
reported
no
ASD.
Conclusions
Although
several
studies
report
three
proposed
groups,
our
data
seem
suggest
symptomatology
Intellectual
Developmental
(IDD).
lack
solid
scientific
evidence
regarding
comorbid
diagnosis
makes
further
research
along
these
lines
indispensable.
Trial
registration
This
study
approved
Ethics
Committee
for
Research
UCLM
reference
CEIS-704,511-L8M4.
Language: Английский
A assessment of the effects of parental age on the development of autism in children: a systematic review and a meta-analysis
BMC Psychology,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 22, 2024
There
has
been
conflicting
evidence
in
earlier
research
on
the
association
between
parental
age
and
autism
risk.
To
clarify
this
association,
we
conducted
a
comprehensive
meta-analysis
of
observational
studies.
The
primary
objective
study
was
to
determine
parents'
risk
offspring.
PubMed,
EMBASE
Web
Science
were
searched
for
reports
published
up
November
2023.
Results
from
relevant
studies
pooled
using
random
effects
models.
Subgroup
analyses
meta-regression
performed
examine
heterogeneity
Studies
included
that
focused
children
with
examined
relationship
(mother
or
father)
autism.The
quality
assessed
Newcastle–Ottawa
Scale
(NOS).
This
41
articles.
low
mother
(OR
=
0.96,
(95%
CIs:
0.88–1.05)
father
1.11,
0.98–1.24)
not
significantly
associated
lower
children.
Conversely,
greater
paternal
maternal
ages
an
increased
their
adjusted
odds
ratios
mothers'
fathers'
1.47
1.33–1.62)
1.51
1.40–1.62),
respectively.
Increased
is
ages.
Further
needed
gain
further
insight
into
mechanisms
responsible
findings
previous
children's
have
mixed.
Therefore,
by
carefully
examining
number
investigations,
aimed
exact
According
study's
findings,
parents
who
are
older
higher
chance
child
getting
autism.
In
other
words,
more
likely
develop
causes
relationship,
however,
still
unclear.
shows
can
be
one
factors
childs.
Language: Английский
What influences parental burnout in parents of children with autism spectrum disorder in China? A qualitative study
Current Psychology,
Journal Year:
2024,
Volume and Issue:
43(32), P. 26193 - 26204
Published: July 9, 2024
Language: Английский
Video-audio neural network ensemble for comprehensive screening of autism spectrum disorder in young children
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(10), P. e0308388 - e0308388
Published: Oct. 3, 2024
A
timely
diagnosis
of
autism
is
paramount
to
allow
early
therapeutic
intervention
in
preschoolers.
Deep
Learning
tools
have
been
increasingly
used
identify
specific
autistic
symptoms.
But
they
also
offer
opportunities
for
broad
automated
detection
at
an
age.
Here,
we
leverage
a
multi-modal
approach
by
combining
two
neural
networks
trained
on
video
and
audio
features
semi-standardized
social
interactions
sample
160
children
aged
1
5
years
old.
Our
ensemble
model
performs
with
accuracy
82.5%
(F1
score:
0.816,
Precision:
0.775,
Recall:
0.861)
screening
Autism
Spectrum
Disorders
(ASD).
Additional
combinations
our
were
developed
achieve
higher
specificity
(92.5%,
i.e.,
few
false
negatives)
or
sensitivity
(90%,
i.e.
positives).
Finally,
found
relationship
between
the
network
modalities
versus
ASD
characteristics,
bringing
evidence
that
implementation
was
effective
taking
into
account
different
are
currently
standardized
under
gold
standard
assessment.
Language: Английский
Investigating Sex-Based Neural Differences in Autism and Their Extended Reality Intervention Implications
Rehma Razzak,
No information about this author
Joy Li,
No information about this author
Selena He
No information about this author
et al.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1571 - 1571
Published: Nov. 9, 2023
Autism
Spectrum
Disorder
(ASD)
affects
millions
of
individuals
worldwide,
and
there
is
growing
interest
in
the
use
extended
reality
(XR)
technologies
for
intervention.
Despite
promising
potential
XR
interventions,
remain
gaps
our
understanding
neurobiological
mechanisms
underlying
ASD,
particularly
relation
to
sex-based
differences.
This
scoping
review
synthesizes
current
research
on
brain
activity
patterns
emphasizing
implications
interventions
neurofeedback
therapy.
We
examine
regions
commonly
affected
by
benefits
drawbacks
technologies,
sex-specific
differences
designing
effective
interventions.
Our
findings
underscore
need
ongoing
into
underpinnings
ASD
differences,
as
well
importance
developing
tailored
that
consider
unique
needs
experiences
autistic
individuals.
Language: Английский
A Sense of Belonging and Help Seeking: Examining Factors Related to the Mental Health of High School Students with High Autistic Traits without Diagnosis
Children,
Journal Year:
2023,
Volume and Issue:
10(12), P. 1927 - 1927
Published: Dec. 14, 2023
Certain
individuals
are
clinically
undiagnosed
for
Autism
Spectrum
Disorder
(ASD)
but
exhibit
strong
ASD
characteristics.
This
study
examined
the
differences
between
a
control
group
and
"high
autistic
traits"
involving
who
scored
9
or
higher
on
Autism-Spectrum
Quotient-16
Japanese
Version,
based
their
sense
of
belonging,
help-seeking
style,
relationship
with
mental
health.
The
participants
were
608
public
high
school
students.
Of
them,
129
(21.2%)
479
(78.8%)
in
traits
groups,
respectively.
A
multiple
regression
analysis
was
performed
using
General
Health
Questionnaire
(GHQ)
as
dependent
variable
groups.
revealed
no
two
groups
regarding
grade,
gender,
physical
illness,
insomnia,
health
status;
however,
they
differed
avoidant
style
teacher
acceptance.
Moreover,
scores
acceptance
showed
significantly
positive
negative
association
GHQ,
results
indicated
that
children
internally
suppress
experiencing
distress.
Teachers
aware
these
students
seek
support
from
seem
reluctant
to
ask
them
help.
can
negatively
impact
traits.
Language: Английский