Oncogenic miR-146a-PBX2 axis, a novel leukemic target in xenograft acute lymphoblastic leukemia model DOI Creative Commons
Samiah Shahid, Maryam Javed, Wajeehah Shahid

et al.

International Journal of Applied and Experimental Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Acute lymphoblastic leukemia (ALL) is one of the major hematological malignancies both in adults and children. Bone marrow biopsy main requirement for its accurate diagnostic prognostic purpose till now that a very painful process especially The reluctance to go bone leads delayed diagnosis treatment ALL. MicroRNAs are emerging as therapeutic targets cancer including ALL using less methods. current study was conducted evaluate potential miR-146a-PBX2 axis leukemic target ALL-induced rabbit model. A total 8 rabbits were divided into two groups: (diseased) normal (control). whole blood collected from groups plasma isolation performed. levels miR-146a PBX2 gene diseased control samples quantified by real-time PCR (RT-qPCR). normalized fold expression calculated miR-16 reference GAPDH. results showed there significant increase (ALL-induced) compared control. Moreover, upregulation found model implied may be utilized

Language: Английский

Flow cytometry analysis of the immunophenotypic properties of CLL and ALL DOI Creative Commons
Khder Hussein Rasul,

Mohammed A Wsoo,

D. Hassan

et al.

Journal of Taibah University Medical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 981 - 989

Published: Sept. 24, 2024

Language: Английский

Citations

0
Oncogenic miR-146a-PBX2 axis, a novel leukemic target in xenograft acute lymphoblastic leukemia model DOI Creative Commons
Samiah Shahid, Maryam Javed, Wajeehah Shahid

et al.

International Journal of Applied and Experimental Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Acute lymphoblastic leukemia (ALL) is one of the major hematological malignancies both in adults and children. Bone marrow biopsy main requirement for its accurate diagnostic prognostic purpose till now that a very painful process especially The reluctance to go bone leads delayed diagnosis treatment ALL. MicroRNAs are emerging as therapeutic targets cancer including ALL using less methods. current study was conducted evaluate potential miR-146a-PBX2 axis leukemic target ALL-induced rabbit model. A total 8 rabbits were divided into two groups: (diseased) normal (control). whole blood collected from groups plasma isolation performed. levels miR-146a PBX2 gene diseased control samples quantified by real-time PCR (RT-qPCR). normalized fold expression calculated miR-16 reference GAPDH. results showed there significant increase (ALL-induced) compared control. Moreover, upregulation found model implied may be utilized

Language: Английский

Citations

0