TM9SF1 inhibits Colorectal Cancer Metastasis by Targeting Vimentin for Tollip-Mediated Selective Autophagic Degradation DOI Creative Commons
Zhibo Liu, Huifen Wang, Jia Hu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Selective autophagy is a finely regulated degradation pathway that can either promote or suppress cancer progression depending on its specific target cargoes. In this study, we report transmembrane 9 superfamily member 1 (TM9SF1) suppresses colorectal (CRC) metastasis via selective autophagic of Vimentin. Tm9sf1 knockout significantly increases tumor numbers and size, as well enhances invasion in CRC model. In vitro in vivo phenotypical analyses reveal TM9SF1 functions suppressor CRC. Mechanistically, facilitates the K63-linked ubiquitination Vimentin by E3 ligase tripartite motif containing 21 (TRIM21). The serves recognition signal for mediated cargo receptor toll interacting protein (Tollip). Consequently, downregulation results decreased number F-actin-rich stress fibers filopodium-like protrusions (FLPs), ultimately inhibiting metastasis. Moreover, downregulated patients with advanced stage compared to those early associated favorable prognosis. Overall, our findings identify novel TM9SF1-TRIM21-Tollip-Vimentin involved metastasis, which may provide promising therapeutic targets treatment metastatic

Language: Английский

Comprehensive multi-omics and single-cell analysis reveals TM9SF1 as a biomarker in pan-cancer diagnosis and prognosis, with a special focus on hepatocellular carcinoma DOI Creative Commons

Fuxiang Luan,

Yuying Cui, Yuxuan Li

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract TM9SF1, a transmembrane protein, has been linked to several cancers, but its role in oncology remains understudied. This study employed machine learning, TCGA, GTEx, and UALCAN databases investigate TM9SF1 expression across various cancers. Prognostic value was assessed using Cox regression Kaplan–Meier methods. Further analyses explored mutations, methylation, immune infiltration, drug sensitivity. Results revealed that significantly elevated multiple tumors associated with poor prognosis. It increased mutation frequency positive correlations stromal scores, as well cells immunomodulators. also correlated tumor heterogeneity, stemness, DNA methyltransferase genes. In hepatocellular carcinoma, it identified an independent risk factor, sensitivity closely related Tex cells. comprehensive analysis underscores TM9SF1’s potential prognostic marker immunotherapy target, significant implications for pan-cancer research.

Language: Английский

Citations

0
TM9SF1 inhibits colorectal cancer metastasis by targeting Vimentin for Tollip-mediated selective autophagic degradation DOI Creative Commons
Huifen Wang, Jia Hu, Di Wang

et al.

Cell Death and Differentiation, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Understanding the role of transmembrane 9 superfamily member 1 in bladder cancer pathogenesis DOI Open Access
Venkata Krishna Vamsi Gade, Budhi Singh Yadav

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(4), P. 468 - 471

Published: April 22, 2024

In this editorial we comment on the article by Wei

Language: Английский

Citations

2
Potential role of transmembrane 9 superfamily member 1 as a biomarker in urothelial cancer DOI
Álvaro Pinto, Abrahams Ocanto, Felipe Couñago

et al.

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(8), P. 965 - 967

Published: Aug. 16, 2024

Bladder cancer is a urological tumor with high rates of recurrence despite recent advances in novel therapies. Many proteins involved the molecular mechanisms are currently an enigma, especially transmembrane 9 superfamily member 1 which has unclear function. Wei

Language: Английский

Citations

0
TM9SF1 inhibits Colorectal Cancer Metastasis by Targeting Vimentin for Tollip-Mediated Selective Autophagic Degradation DOI Creative Commons
Zhibo Liu, Huifen Wang, Jia Hu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Selective autophagy is a finely regulated degradation pathway that can either promote or suppress cancer progression depending on its specific target cargoes. In this study, we report transmembrane 9 superfamily member 1 (TM9SF1) suppresses colorectal (CRC) metastasis via selective autophagic of Vimentin. Tm9sf1 knockout significantly increases tumor numbers and size, as well enhances invasion in CRC model. In vitro in vivo phenotypical analyses reveal TM9SF1 functions suppressor CRC. Mechanistically, facilitates the K63-linked ubiquitination Vimentin by E3 ligase tripartite motif containing 21 (TRIM21). The serves recognition signal for mediated cargo receptor toll interacting protein (Tollip). Consequently, downregulation results decreased number F-actin-rich stress fibers filopodium-like protrusions (FLPs), ultimately inhibiting metastasis. Moreover, downregulated patients with advanced stage compared to those early associated favorable prognosis. Overall, our findings identify novel TM9SF1-TRIM21-Tollip-Vimentin involved metastasis, which may provide promising therapeutic targets treatment metastatic

Language: Английский

Citations

0