Ionizing radiation enhances tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐induced apoptosis through up‐regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells

Journal of Orthopaedic Research®, Journal Year: 2009, Volume and Issue: 28(6), P. 739 - 745

Published: Dec. 29, 2009

Despite improvements in chemotherapy and surgery the treatment of osteosarcoma (OS), satisfactory results are still difficult to achieve. Novel therapeutic modalities need be developed for treatment. The combined effects tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) ionizing radiation (IR) on human OS cells were investigated. IR TRAIL synergistically decreased cell viability enhanced apoptosis lines. pretreatment enhances TRAIL-induced Bid caspase-3 activations. Decreases expression levels antiapoptotic proteins c-FLIP XIAP also associated with enhancement. Furthermore, DR4 DR5 expressions at transcription stage. These can become basic lines evidence future using IR.

Language: Английский

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Prion proteins (PRNP and PRND) are over‐expressed in osteosarcoma

Journal of Orthopaedic Research®, Journal Year: 2011, Volume and Issue: 30(6), P. 1004 - 1012

Published: Dec. 6, 2011

Abstract Although osteosarcoma is the most common bone malignancy, molecular and cellular mechanisms influencing its pathogenesis have remained elusive. Prion proteins (PRNP PRND), known mostly for involvement in neurodegenerative spongiform encephalopathies, been recently demonstrated to be involved resistance apoptosis, tumorigenesis, proliferation, metastasis. The main aim of research was study whether prion were over‐expressed human osteosarcoma, if could a role also osteosarcomas. We evaluated differential gene expression between 22 cases 40 normal specimens through cDNA microarray analysis spanning substantial fraction genome. PRNP PRND are significantly osteosarcoma. appear with some important genes related tumorigenesis apoptosis. linked PTK2, RBBP9, TGFB1 while TNFSF10, BCL2A1, NFKB2, TP53RK. Increased on Affymetrix arrays seems associated development Prions seem induce negative regulation thus promoting progression. Osteosarcoma very aggressive tumor even after modern chemotherapy excision tumors efforts needed improve clinical outcome. Since development, their inhibition represent new approach treatment © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1004–1012, 2012

Language: Английский

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Advances in Target Therapy Research in Osteosarcoma

Published: Feb. 28, 2024

Osteosarcoma (OS) are the most prevalent malignant bone tumors in adolescents and young adults.. OS cells grow a permissive local microenvironment which modulates their behavior facilitates all steps tumor development (e.g., proliferation/quiescence, invasion/migration, drug resistance) contributes to intrinsic heterogeneity. The lung parenchyma is common metastatic site OS, foci frequently associated with poor clinical outcome. Although multiple factors may be responsible for disease, including genetic mutations Rb, p53), molecular mechanism of remains unclear conventional treatment still based on sequential approach that combines chemotherapy surgery. Also, despite increase trials, survival rates have not improved. Non-specific targeting therapies thus show therapeutic effects side at high doses. For these reasons, many efforts been done characterize complex genome osteosarcoma thanks whole exome analysis aim identify predictive biomarkers give patients better option. This review aims summarize discuss main recent advances research precision medicine.

Language: Английский

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Pediatric Pathology Services in Africa

Archives of Pathology & Laboratory Medicine, Journal Year: 2013, Volume and Issue: 137(6), P. 767 - 774

Published: May 30, 2013

Like other pathology services in developing settings, pediatric Africa is faced with major challenges such as limited access to resources and few opportunities for professional advancement. Additionally, the discrepancy between large burden of diseases, many which individually are rare enough prove challenging general pathologist, amount specialized training available compounds underlying problems makes provision a high-quality service difficult. Pediatric neoplasms particular chief cause concern among pathologists practicing Africa.To provide relevant information an emphasis on malignancies Africa, where children represent very high proportion population incomplete.Authors' experience literature.The limitations inherent working within low-resource setting may be reduced by thoughtful purposeful triaging specimens, prudent use cytology facilitating rapid inexpensive diagnoses, collaboration outside continent. Increased investment advocacy child health, including creation additional hospitals dedicated care children, likely necessary significantly advance children's health region.

Language: Английский

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Osteosarcoma Review

Biomedical Journal of Scientific & Technical Research, Journal Year: 2023, Volume and Issue: 50(2)

Published: May 4, 2023

Osteosarcoma refers to a bone tumor and the term was introduced by John Abernathy in 1804 referring fleshy growth [1]. In 2009, Ottaviane G. et al reported that osteosarcoma is an aggressive malignancy arises from primitive transformed cells of mesenchymal origin produces malignant osteoid, which are most common representation primary cancer [2,3].

Language: Английский

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Acompanhamento do paciente tratado de osteossarcoma

Published: Oct. 7, 2010

Osteosarcoma, the most common malignant primary bone tumor, with incidence rates, for adolescents between 15 to 19 years old, of 8-11 cases/ million.In Brazil, it is estimated 350 year until 20 age.It has a survival up 70% in five non-metastatic ones and global 80%.When they relapse, this reaches 20% one year, might reach 40 % years.Osteosarcoma patients should be followed up, frequently, radiologic studies investigate metastases, at least after end treatment, which more intensive two first years, where relapses occur.Aim: To evaluate post-treatment follow-up osteosarcoma patients.Material methods: A retrospective study carried out Fundação PioXII -Hospital de Câncer Barretos evaluated 52 who were treated by Pediatrics Department, January, 2000 June, 2006.Data collected using clinical file comprised socio-demographic data.Results: analyzed, 61,5% male, mean age was 48,1% from São Paulo State.In regard variables, 59,6% relapsed, those, 58% have lung relapses.44,4%of had relapses, presented some kind complain did not move their visits.There no statistically significant difference demographic features early attendance visits, people lived less than two-hour-trip hospital represented 33,3% whereas 21-hour-trip, 30,8% (p=0,073).The relapse showed association late visit, because 12,9% (p=0,006).Among patients,

Language: Английский

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Chondroblastic variant of gnathic osteosarcoma– A rare case report

International Journal of Maxillofacial Imaging, Journal Year: 2018, Volume and Issue: 4(2), P. 59 - 61

Published: Oct. 6, 2018

Osteosarcomas are the most common primary malignant neoplasm of bone. predominantly occur in long bones and rare maxillofacial region. Gnathic osteosarcoma differs from its biological behavior even though they have similar histologic appearance. The maxillary osteosarcomas show predilection for posterior portion alveolar process antrum, whereas mandible, body is commonly involved site followed by angle, symphysis ascending ramus. We report a case maxilla 62 year old male patient which was diagnosed histopathologically as chondroblastic variant osteosarcoma. treatment comprised surgery radiation therapy. Keywords: Chondroblastic, Jaw, Osteosarcoma, Maxilla

Language: Английский

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Recurrent Giant Cell-Rich Osteosarcoma of the Jaw- a Case Report and Review of the Literature

Medical Journal of Zambia, Journal Year: 2022, Volume and Issue: 48(3), P. 350 - 351

Published: Jan. 12, 2022

Giant cell-rich osteosarcoma of the jaw (JGCRO) is very rare but it diagnostically important because its poor prognosis compared to other variants osteosarcoma. We report a case recurrent JGCRO initially diagnosed as an ossifying fibroma. The clinical presentation, radiologic and histologic features intermediate outcome treatment are highlighted.

Language: Английский

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