Anthocyanins’ effects on diabetes mellitus and islet transplantation

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(33), P. 12102 - 12125

Published: July 13, 2022

The incidence of diabetes mellitus is dramatically increasing every year, causing a huge global burden. Moreover, existing anti-diabetic drugs inevitably bring adverse reactions, and the application islet transplantation often limited by damage caused oxidative stress after transplantation. Thus, new approaches are needed to combat growing burden mellitus. Anthocyanins great nutritional interest have been documented that beneficial effects on chronic diseases, including Here, we describe health anthocyanins Epidemiological studies demonstrated moderate intake leading reduction in risk Numerous experiments both animal clinical also showed positive prevention treatment diabetic complications. These may be related mechanisms improving glucose lipid metabolism insulin resistance, antioxidant, anti-inflammatory activities. In addition, function pancreatic islets improved anthocyanins. findings suggest daily not only improve healthy individuals prevent from diabetes, but as supplementary more evidence better understand potential benefits

Language: Английский

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Evaluation of Clove Phytochemicals as Potential Antiviral Drug Candidates Targeting SARS-CoV-2 Main Protease: Computational Docking, Molecular Dynamics Simulation, and Pharmacokinetic Profiling

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: June 28, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can cause a sudden disease spreading with high mortality rate arising unknown mechanisms. Still, there is no proper treatment available to overcome the disease, which urges research community and pharmaceutical industries screen novel therapeutic intervention combat current pandemic. This study exploits natural phytochemicals obtained from clove, traditional that comprises important bioactive compounds used for targeting main protease of SARS-CoV-2. As result, inhibition viral replication effectively procures by protease, responsible inside host. Pharmacokinetic studies were evaluated property drug likeliness. A total 53 bioactives subjected study, four among them, namely, eugenie, syzyginin B, eugenol, casuarictin, showed potential binding properties against target SARS-CoV-2 protease. resultant best was compared commercially standard drugs. Furthermore, validation respective comprehensive molecular dynamics simulation performed using Schrödinger software. To further validate delimit screening process drugs 2019, in vitro vivo clinical are needed prove their efficacy.

Language: Английский

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Integrating Ethnobotany and Artificial intelligence to validate the potential bioactivity of Two Medicinal Plants Traditionally used in the treatment of influenza in IBI-Village and surrounding areas, Democratic Republic of the Congo

Natural Resources for Human Health, Journal Year: 2024, Volume and Issue: 4(3), P. 230 - 246

Published: June 7, 2024

The research conducted an investigation into the utilization of medicinal plants for treating influenza, while also employing molecular modeling to scientifically validate their traditional applications. Informants were selected from IBI-Village and its environs using a snowball sampling technique. Data collection utilized semi-structured questionnaires interviews. Consensus among informants cultural significance assessed. A total 40 employed in influenza care identified, including <i>Cymbopogon citratus</i>, <i>Ocimum gratissimum</i>, <i>Tetradenia riparia</i>, <i>Eucalyptus globulus</i>, <i>Citrus limon</i>, <i>Zingiber officinalis</i>, <i>Lippia multiflora</i>. majority these shrubs trees. Analysis revealed that marital status influenced only mode recipe administration. Respondents categorized based on ethnomedical practices: some prescribed plant condition parts used, others focused administration mode, preparation method, form use. Molecular docking demonstrated compounds formed stable complexes, five classes: Neral Eugenol (Class 1), Fenchone Oseltamivir 2), Eucalyptol 1,8-Cineole 3), (+)-Limonene 4), Zingiberene 5). two four hydrogen bonds with receptor, respectively. dynamics simulations showed around 300 amino acid residues interacting ligand, specific like Arg_706, Val_709, Ser_712, Arg_721 forming Eugenol. integration dynamics, docking, ethnobotany highlighted potential efficacy <i>C. citratus</i> <i>O. gratissimum</i> against at level. Formulating pharmaceuticals essential oils could enhance management.

Language: Английский

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Phytochemical Study and Evaluation of the Antidiabetic and Antihyperglycemic Activities of the Fruit Extracts of Physalis peruviana L. (Solanaceae).

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 5(1), P. 100675 - 100675

Published: Nov. 10, 2024

Language: Английский

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