Ki-67 expression and its correlation with clinicopathological parameters in Iraqi breast cancer patients DOI Open Access

Ammar Ahmed Hussein,

Rayah Baban,

Qahtan A. Mahdi

et al.

International Journal of Health Sciences, Journal Year: 2024, Volume and Issue: 8(2), P. 158 - 169

Published: July 27, 2024

Breast cancer is the most common worldwide and major cause of cancer-related death among women in both developed developing countries. In Iraq, breast accounted for 37.9% all malignant cases 2020 15.3% fatalities. Relevant biomarkers play an important role predicting prognosis deciding effective therapy each patient to delay metastases reduce mortality. Objective: This study aimed assess significance Ki-67 expression as a prognostic biomarker patients well investigate correlations between their clinicopathological features. Methods: The case-control comprised sixty newly diagnosed ten with benign tumors who served controls. We assessed tissue level protein using immunohistochemistry technique. Results: Our results showed that median immunohistochemical scores group were higher than those control group; difference was significant (p < 0.001). score cells increases tumor size grade. substantial negative correlation estrogen receptor positive HER2 expression.

Language: Английский

Ki-67 expression and its correlation with clinicopathological parameters in Iraqi breast cancer patients DOI Open Access

Ammar Ahmed Hussein,

Rayah Baban,

Qahtan A. Mahdi

et al.

International Journal of Health Sciences, Journal Year: 2024, Volume and Issue: 8(2), P. 158 - 169

Published: July 27, 2024

Breast cancer is the most common worldwide and major cause of cancer-related death among women in both developed developing countries. In Iraq, breast accounted for 37.9% all malignant cases 2020 15.3% fatalities. Relevant biomarkers play an important role predicting prognosis deciding effective therapy each patient to delay metastases reduce mortality. Objective: This study aimed assess significance Ki-67 expression as a prognostic biomarker patients well investigate correlations between their clinicopathological features. Methods: The case-control comprised sixty newly diagnosed ten with benign tumors who served controls. We assessed tissue level protein using immunohistochemistry technique. Results: Our results showed that median immunohistochemical scores group were higher than those control group; difference was significant (p < 0.001). score cells increases tumor size grade. substantial negative correlation estrogen receptor positive HER2 expression.

Language: Английский

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