Opioid use and subsequent delirium risk in patients with advanced cancer in palliative care: a multicenter registry study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 12, 2024

Abstract The prevalent use of opioids for pain management in patients with advanced cancer underscores the need research on their neuropsychiatric impacts, particularly delirium. Therefore, we aimed to investigate potential association between opioid and risk delirium admitted acute palliative care unit. We conducted a retrospective observational study utilizing multicenter, patient-based registry cohort by collecting data from January 1, 2019, December 31, 2020, South Korea. All regarding exposures, outcomes, covariates were obtained through chart reviews team specialized medical professionals expertise oncology. Full unmatched 1:1 propensity-score matched cohorts formed, stratification analysis was conducted. primary outcome, delirium, defined diagnosed DSM-IV. Of 2,066 cancer, identified 42.8% (mean [SD] age, 64.4 [13.3] years; 60.8% male) non-opioid users 57.2% (62.8 [12.5] 55.9% users, respectively. Opioid significantly associated an increased occurrence (OR, 2.02 [95% CI 1.22–3.35]). showed increasing trends dose-dependent manner. High-dose compared (low-dose user: OR, 2.21 1.27–3.84]; high-dose 5.75 2.81–11.77]; ratio 2.60 1.05–6.44]). Patients old male sex, absence chemotherapy during hospitalization, non-obese status more susceptible cancer. In this multicenter study, found significant, also specific patient groups These findings highlight importance prescription these balancing effective doses adverse dose-inducing

Language: Английский

Nationwide trends in the prevalence of cataract, glaucoma, and macular degeneration among Korean adults amid the COVID-19 pandemic, 2015-2021: A representative study in South Korea

Life Cycle, Journal Year: 2024, Volume and Issue: 4

Published: June 1, 2024

Language: Английский