Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy DOI Creative Commons
Yanting Liu, Fang Liu, Yan Zeng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 13, 2024

Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment’s (TIME) complexity heterogeneity challenge immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility drug release control, which widely used in delivery, agriculture, industry, etc. Hydrogels loaded cells, cytokines, checkpoint inhibitors, anti-tumor drugs can achieve targeted delivery ultimately activate response TIME. In this review, we will summarize components of TIME their effects, emerging immunomodulatory agents, characteristics functions hydrogels, how hydrogels regulate cells

Language: Английский

Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems DOI Creative Commons
Sivakumar S. Moni, Jobran M. Moshi, Sabine Matou‐Nasri

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 296 - 296

Published: Feb. 24, 2025

Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.

Language: Английский

Citations

1
Innovative hydrogel-based delivery systems for immunotherapy: A review of pre-clinical progress DOI
Narsimha Mamidi, Michael J. Poellmann,

Kaila Javius-Jones

et al.

Nano Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

2
A Comprehensive Guide to Hydrogel-Based Controlled Drug Delivery for Cancer Treatment DOI Open Access

J Pavan Kumar,

Chennu MM Prasada Rao,

Ranjan Kumar Singh

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(8), P. 195 - 200

Published: Aug. 15, 2024

Common kinds of chemotherapy may cause harm to normal cells and tissues. Localised chemotherapy, unlike systemic can lessen side effects by providing a consistent supply chemotherapeutic chemicals directly the tumour location. This emphasises importance controlled-release biodegradable hydrogels as drug delivery systems. study looks at employing methods for HCC, including thermosensitive, pH-sensitive, photosensitive, dual-sensitive, glutathione-responsive hydrogels. Hydrogel-based systems outperform traditional in cancer treatment. Cancer immunotherapy has emerged new paradigm The development discovery therapeutic molecules increased use clinical studies. article discusses current state functional effective immunotherapy. First, we will discuss fundamental principles benefits implement these mechanisms. Finally, briefly explore existing issues potential applications Keywords: Cancer, controlled system, postoperative radiotherapy, Immunotherapy.

Language: Английский

Citations

1
Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy DOI Creative Commons
Yanting Liu, Fang Liu, Yan Zeng

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 13, 2024

Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment’s (TIME) complexity heterogeneity challenge immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility drug release control, which widely used in delivery, agriculture, industry, etc. Hydrogels loaded cells, cytokines, checkpoint inhibitors, anti-tumor drugs can achieve targeted delivery ultimately activate response TIME. In this review, we will summarize components of TIME their effects, emerging immunomodulatory agents, characteristics functions hydrogels, how hydrogels regulate cells

Language: Английский

Citations

1