From cells to society: untangling the web of stress, inflammation, and social determinants of health

Frontiers in Science, Journal Year: 2024, Volume and Issue: 2

Published: March 12, 2024

From cells to society: untangling the web of stress, inflammation, and social determinants health

Language: Английский

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Where do we go from here? The personal impact of adverse events and complications in surgeons: Results from a cross-sectional study

The Surgeon, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Medical error is an inevitable part of modern healthcare, with a potential harmful impact for the patient and surgeon. The phenomenon negative personal responses healthcare workers in aftermath adverse events described as "second casualty" can involve significant physical psychological distress. We present results from cross-sectional survey surgeons their experience or complications. Following ethical approval anonymous online was distributed to all training consultant Republic Ireland. Data collected included basic demographics, response event, coping strategies, contributing factors perception support structures. A total 110 were received representing broad range specialty. Eighty-nine percent (n = 98) symptoms events. predominant anxiety, guilt low mood. Sixty-seven 74) reported that did not prepare them but found informal peer family be beneficial open implementation formal Surgeons suffer outcomes feel unprepared manage consequences. Institutions representative bodies must step forward change culture develop supports

Language: Английский

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Epigenetic factors in posttraumatic stress disorder resilience and susceptibility

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 20, 2025

Abstract Background Posttraumatic stress disorder (PTSD) affects approximately 8% of the US population, with varying susceptibility among individuals exposed to trauma. While genetic factors contribute PTSD risk, emerging evidence suggests that epigenetic mechanisms play a crucial role in translating environmental exposures into lasting neurobiological changes. Purpose This review provides comprehensive analysis cutting-edge research on PTSD, particular emphasis novel findings regarding resilience and mechanisms. We explore recent technological advances their applications understanding pathophysiology. Main body Advanced epigenomic approaches have revealed complex interactions between DNA methylation, histone modifications, non-coding RNAs PTSD. Novel highlight cell type-specific signatures temporal dynamics following trauma exposure. Single-cell studies identified previously unknown cellular heterogeneity responses. Recent data modifications not only influence individual but may also transgenerational transmission effects. Integrative multi-omics new insights molecular networks underlying vulnerability. Conclusion unprecedented complexity These open avenues for personalized interventions based profiles suggest therapeutic strategies targeting modifications. enhanced has significant implications risk assessment, prevention, treatment. Graphical abstract

Language: Английский

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Epilepsy and criminal behavior (review of literature)

V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Journal Year: 2025, Volume and Issue: 59(1), P. 8 - 17

Published: March 28, 2025

With epilepsy, behavioral disorders are possible, including criminal ones. Criminal incidents can occur in the preictal, interictal, ictal and postictal periods, may be due to adverse events of anticonvulsants other factors. The most dangerous disorder, terms incidents, is psychosis.Often people with epilepsy need experienced neurologists lawyers resolve situations. International League Against Epilepsy recommends criteria for determining whether a particular act committed by patient result an epileptic seizure.In general, forensically sound, comprehensive interdisciplinary approach diagnosis behavior required, which combines neuropsychiatric, neuropsychological psychophysiological methods, taking into account risk factors aggravating

Language: Английский

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Garcia Adaptive Equilibrium Theory (GAET): A New Nursing Theory for Mental Health Nursing

Issues in Mental Health Nursing, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 23, 2025

Mental health nursing demands a dynamic, patient-centered approach that goes beyond crisis intervention and symptom management. Traditional models like the Roy Adaptation Model Tidal emphasize adaptation recovery but fall short in capturing fluid, nonlinear nature of mental health. The Garcia Adaptive Equilibrium Theory (GAET) introduces new framework viewing as continuous balancing process. In this model, nurses serve Facilitators, identifying points instability intervening early to prevent crises.Central GAET is Spectrum, which conceptualizes fluctuating continuum-from stability severe distress. Unlike traditional psychiatric approaches focused on reactive treatment, incorporates Forecasting, proactive assessment strategy integrates subjective tools (scales, narratives) objective data (biomarkers, physiologic signs) anticipate deterioration.By reframing care around real-time stabilization, promotes intervention, sustained well-being, shift toward preventive, holistic care. This theory redefines an active, interdisciplinary practice maintaining equilibrium rather than responding disruption-empowering lead stabilization prevention.

Language: Английский

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Influencing Factors and Intervention Progress of Psychological Resilience in Adolescents

Advances in Psychology, Journal Year: 2025, Volume and Issue: 15(01), P. 205 - 212

Published: Jan. 1, 2025

Language: Английский

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Thriving Through Stressful Life Events with Nature: A Mixed-Method Study on Tending Indoor Plants and Rumination Resilience

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 369 - 369

Published: March 3, 2025

Stressful life events are often undesirable, inevitable, and significant changes in one's life, triggering rumination posing risks to mental health. However, these can be managed through coping strategies. Contact with nature has been shown reduce enhance well-being. The current study investigated the effectiveness of a one-month nature-based intervention enhancing psychological well-being building resilience manage following stressful event. In this mixed-method study, 26 participants were randomly allocated either an experimental group (n = 13), which tended Zamioculcas zamiifolia indoor plant for one month, or waitlist control 13). Quantitative findings showed that tending plants was significantly effective reducing depressive symptoms (p 0.003), perceived stress < 0.001), negative affect 0.017), 0.015), as well 0.03) compared post-intervention. Qualitative provided insight into how fosters resilience, mediating effects plant, contribution it makes 'Offers slice by bringing outside, in' demonstrates caring creates bridge connection nature. 'Fosters emotionally regulating personal sanctuary' captures help emotions provide sense empowerment helps mitigate tendency ruminate. 'Plants seeds improving self-care, growth introspection' highlights symbolic representation renewal. A narrative emerges: grow thrive attention, so too does individual, forming deep, reciprocal relationship between This nature's role developing paving way further research explore its caveats refine expand interventions.

Language: Английский

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The Human Superorganism: Using Microbes for Freedom vs. Fear

Applied Microbiology, Journal Year: 2023, Volume and Issue: 3(3), P. 883 - 905

Published: Aug. 10, 2023

Balanced fear supports human rational decision-making and useful behavioral responses. In contrast, overwhelming, persistent, unbalanced can paralyze the individual result in heightened anxiety, lack of cognitive flexibility, fear-based public compliance serious mental health issues. Psychobiotics research has established that a healthy microbiome is required for balanced protection via control extinction. The recent COVID-19 pandemic featured daily, fear-of-a-single-contagion conditioning on global scale paired with various mandates (e.g., lockdowns healthy, wearing face masks many locations including schools, isolation from environmental microbes each other through closure beaches parks, restrictions social gatherings access to family members hospitals senior-assisted facilities). Such degraded isolated us microbes. It also ignored historic role secondary bacterial pathogens deaths. This narrative review examines how institutional promotion fear-of-a-single-contagion, risk communication, appalling disregard our fundamental nature (as majority-microbial superorganisms) resulted problems rather than solutions. illustrates government-public health-media pervasive microbiome-degrading behaviors: (1) increased compliance, (2) reduced (3) conditions. However, portion general chose healthier path their consumption microbiome- immune-supportive supplements fermented foods during after pandemic. For future, must follow lead this population ensure freedom, paralyzing fear, dominates future.

Language: Английский

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Caring for the Caregivers: Improving Mental Health among Health Professionals Using the Behavioral Health Professional Workforce Resilience ECHO Program

Healthcare, Journal Year: 2024, Volume and Issue: 12(17), P. 1741 - 1741

Published: Aug. 31, 2024

Behavioral health professionals are at high risk for burnout and poor mental health. Our objective was to understand the impact of Health Providers Workforce Resiliency (BHPWR) ECHO Program on resilience participating behavioral professionals. We assessed first two years (March 2022 March 2024) BHPWR ECHO, a national program operating from University New Mexico (N = 1585 attendees), using mixed-methods design. used retrospective pre/post survey (n 53 respondents) focus interviews with 1–3 participants 9 participants) assess changes in knowledge confidence resilience. found that increased their how respond when (1) workload more than they could manage, (2) felt lacked control, (3) work did not feel rewarding, (4) were experiencing compassion fatigue. They building support system wellness tools taught course. Respondents less burnt out (score: 26.0 versus 17.8, p < 0.01) resilient (29.9 34.9, compared started attending program. Tele-mentoring programs like may improve among care

Language: Английский

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Mind Matters: The Neuroscience of Workplace Resilience

Neurology and Neuroscience, Journal Year: 2023, Volume and Issue: 4(4)

Published: Dec. 30, 2023

This paper provides an exploration of the neuroscience underpinning workplace resilience, offering insights into brain's stress response system and its profound implications for employee wellbeing in diverse organisational settings. An examination is explored, elucidating neural pathways structures involved, notably amygdala prefrontal cortex. elucidation serves as a foundational component understanding neurological basis resilience professional milieu. analysis illuminates neurobiological repercussions prolonged exposure cognitive ramifications. In more optimistic stride, article explores concept neuroplasticity centrality nurturing spotlighting how offers pivotal avenue crafting resilience-building programs.

Language: Английский

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