Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 8, 2024

Crohn’s disease (CD) is a chronic inflammatory that most frequently affects part of the distal ileum, but it may affect any gastrointestinal tract. CD also be related to systemic inflammation and extraintestinal manifestations. Alzheimer’s (AD) common neurodegenerative disease, gradually worsening behavioral cognitive functions. Despite meaningful progress, both diseases are still incurable have not fully explained, heterogeneous pathomechanism includes immunological, microbiological, genetic, environmental factors. Recently, emerging evidence indicates condition corresponds an increased risk diseases, intestinal inflammation, including CD, increases AD. Even though now known AD, exact pathways connecting these two seemingly unrelated remain unclear. One key postulates gut-brain axis. There increasing gut microbiota with its proteins, DNA, metabolites influence several processes etiology β-amyloid abnormality, Tau phosphorylation, neuroinflammation. Considering role in AD pathology, this review, we want shed light on bacterial amyloids their potential cerebral amyloid aggregation neuroinflammation provide overview current literature as linker between CD.

Language: Английский

Mendelian randomization and genetic pleiotropy analysis for the connection between inflammatory bowel disease and Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111203 - 111203

Published: Nov. 22, 2024

Language: Английский